Exploration, EarlyView.The deficiency of PNLDC1 exacerbates the advancement of CRC. PNLDC1 interacts with TUBB4B mRNA to regulate the p53–p21–CDK2–cyclin E2 pathway, thereby influencing the G2/M phase of the cell cycle. ABSTRACT Colorectal cancer (CRC) remains a leading cause of cancer‐related mortality, highlighting the urgent need for novel therapeutic strategies.
Lexin Liu +18 more
wiley +1 more source
Nucleoside Analog Reverse-Transcriptase Inhibitors in Membrane Environment: Molecular Dynamics Simulations. [PDF]
Molecules, 2023 Stachowicz-Kuśnierz A +2 more
europepmc +1 more source
Under‐Explored Species, Breeds and Cell Types With Potential for Cultivated Meat Production
Food Bioengineering, EarlyView.This graphical abstract illustrates how the strategic selection of overlooked cell lines from novel species and specific agricultural breeds can help overcome current manufacturing bottlenecks in cultivated meat production. The schematic links the concept of an ‘ideal cell line’ to four key bioprocessing and product advantages that can be optimised ...
William Gordon‐Petrovskii +6 more
wiley +1 more source
Kasmera, 2010 A prospective study was carried out to determine the effect of antiretroviral therapy on the lipid profile in a population of 50 patients with AIDS who received their first antiretroviral drug treatment in the HIV-AIDS clinic at the Maracaibo University ...
Isabel Soto +2 more
doaj
Illuminating point‐of‐care diagnostics with aggregation‐induced emission biosensors
FlexMat, EarlyView.This review highlights the application of aggregation‐induced emission luminogens (AIEgens) in point‐of‐care (POC) diagnostics for disease biomarker detection. It systematically examines a range of biosensing platforms, including lateral flow immunoassays, microfluidic chips, and electrochemiluminescence sensors, alongside their utility in detecting ...
Danni Hu +3 more
wiley +1 more source
Advanced Genetics, Volume 6, Issue 1, March 2025.This study comprehensively evaluated the differential effect of clonal hematopoiesis (CH) mutations on the risk of various stroke subtypes and functional recovery. It shows that TET2 is associated with small vessel stroke possibly via a pro‐inflammatory pathway. Abstract Recent observational studies have found an association between Clonal Hematopoesis
Shuyang Lin, Yang E. Li, Yan Wang
wiley +1 more source
The impact of the recent HIV non-nucleoside reverse transcriptase inhibitors and nucleoside reverse transcriptase inhibitors-based regimens on metabolic health outcomes: A narrative review. [PDF]
Biochem Biophys RepSedibe A +3 more
europepmc +1 more source
Biochemical and structural comparisons of non-nucleoside reverse transcriptase inhibitors against feline and human immunodeficiency viruses. [PDF]
J Vet Sci, 2023 Rattanabunyong S +8 more
europepmc +1 more source
Nucleoside-Analog Reverse-Transcriptase Inhibitors (NRTIs) Against Multiple Sclerosis: Comprehensive Review on a Possible Novel Therapeutic Approach. [PDF]
Neurol IntMartinisi A, Paganetti P.
europepmc +1 more source
Reverse transcriptase inhibitors enable the generation of fertile spermatids from fetal mouse testes in vitro. [PDF]
Commun BiolNishida M +11 more
europepmc +1 more source