Results 181 to 190 of about 399,014 (392)

Mapping Molecular Pathways of Multiple Sclerosis: A Gene Prioritization and Network Analysis of White Matter Pathology Transcriptomics

Annals of Neurology, EarlyView.
Objectives Rapid advances in transcriptomics have driven efforts to identify deregulated pathways in multiple sclerosis (MS) tissues, though many detected differentially expressed genes are likely false positives, with only a small fraction reflecting actual pathological events. Robust, integrative methods are essential for accurately understanding the
Gianmarco Abbadessa, Ai Nagano, Simon Hametner, Owain Howell, David Owen, Artemis Papadaki, Prashant Srivastava, Simona Bonavita, Roberta Magliozzi, Richard Reynolds, Mie Rizig, Richard Nicholas   +11 more
wiley   +1 more source

Antibiotics from basidiomycetes XLI. Clavicoronic acid, a novel inhibitor of reverse transcriptases from Clavicorona pyxidata (Pers. ex Fr.) Doty.

, 1992
Gerhard Erkel, Timm Anke, Alberto Giménez, Wölfgang Steglich   +3 more
openalex   +2 more sources

Nucleoside Analog Reverse-Transcriptase Inhibitors in Membrane Environment: Molecular Dynamics Simulations. [PDF]

Molecules, 2023
Stachowicz-Kuśnierz A, Korchowiec B, Korchowiec J.   +2 more
europepmc   +1 more source

Chimeric human immunodeficiency virus type 1/type 2 reverse transcriptases display reversed sensitivity to nonnucleoside analog inhibitors.

, 1991
C K Shih, Janice Rose, Gesine Hansen, Joseph C. Wu, Albino Bacolla, Judith A. Griffin   +5 more
openalex   +1 more source

Phenylethylthiazolylthiourea (PETT) Non-nucleoside Inhibitors of HIV-1 and HIV-2 Reverse Transcriptases [PDF]

, 2000
Jingshan Ren, Jonathan M. Diprose, Jonathan Warren, Robert Esnouf, Louise E. Bird, Shinji Ikemizu, Martin J. Slater, John Milton, Jan Balzarini, David I. Stuart, D.K. Stammers   +10 more
openalex   +1 more source

Absence of Functional Autoantibodies Targeting Angiotensin II Receptor Type 1 and Endothelin‐1 Type A Receptor in Circulation and Purified IgG From Patients With Systemic Sclerosis

Arthritis &Rheumatology, EarlyView.
Objective Systemic sclerosis (SSc) is a rare but severe autoimmune disease characterized by immune dysregulation, fibrosis, and vasculopathy. Although previous studies have highlighted the presence of functional autoantibodies targeting the angiotensin II receptor type 1 (AT1) and endothelin‐1 type A receptor (ETAR), leading to autoantibody‐mediated ...
Wieke M. van Oostveen, Eva M. Hoekstra, E. W. Nivine Levarht, Ilana B. Kotliar, Thomas P. Sakmar, René E. M. Toes, Jeska K. de Vries‐Bouwstra, Laura H. Heitman, Cynthia M. Fehres   +8 more
wiley   +1 more source

Exploring the hydrophobic channel of NNIBP leads to the discovery of novel piperidine-substituted thiophene[3,2-d]pyrimidine derivatives as potent HIV-1 NNRTIs

Acta Pharmaceutica Sinica B, 2020
In this report, a series of novel piperidine-substituted thiophene[3,2-d]pyrimidine derivatives were designed to explore the hydrophobic channel of the non-nucleoside reverse transcriptase inhibitors binding pocket (NNIBP) by incorporating an aromatic ...
Dongwei Kang, Da Feng, Tiziana Ginex, Jinmi Zou, Fenju Wei, Tong Zhao, Boshi Huang, Yanying Sun, Samuel Desta, Erik De Clercq, Christophe Pannecouque, Peng Zhan, Xinyong Liu   +12 more
doaj  

Development of non-nucleoside reverse transcriptase inhibitors (NNRTIs): our past twenty years

Acta Pharmaceutica Sinica B, 2019
Chunlin Zhuang, C. Pannecouque, E. De Clercq, Fener Chen   +3 more
semanticscholar   +1 more source

An Immunosenescent CD8+ T Cell Subset in Patients with Axial Spondyloarthritis and Psoriatic Arthritis Links Spontaneous Motility to Telomere Shortening and Dysfunction

Arthritis &Rheumatology, EarlyView.
Objective A pathogenetic role of CD8+ T lymphocytes in radiographic axial spondyloarthritis (r‐axSpA) and other spondyloarthritis (SpA) is sustained by genome‐wide association studies and by the expansion of public T cell clonotypes in the target tissues.
Giorgia Paldino, Valentina Tedeschi, Valentina Proganò, Erica Salvati, Valerio Licursi, Eleonora Vertecchi, Alexandru L. Bivolaru, Emanuele Molteni, Rossana Scrivo, Mattia Congia, Alberto Cauli, Rosalba Caccavale, Marino Paroli, Martina Kunkl, Loretta Tuosto, Rosa Sorrentino, Maria Teresa Fiorillo   +16 more
wiley   +1 more source

Biochemical and structural comparisons of non-nucleoside reverse transcriptase inhibitors against feline and human immunodeficiency viruses. [PDF]

J Vet Sci, 2023
Rattanabunyong S, Choengpanya K, Suwattanasophon C, Kiriwan D, Wolschann P, Lamtha T, Shaikh AR, Rattanasrisomporn J, Choowongkomon K.   +8 more
europepmc   +1 more source