Results 181 to 190 of about 125,916 (291)

Physiologically based pharmacokinetic model combined with a clinical lactation study to determine doravirine concentrations in human breastmilk

British Journal of Clinical Pharmacology, EarlyView.
Aims To determine breastmilk concentrations of doravirine via PBPK modelling in combination with a clinical lactation study. As women living with HIV are not able to cease antiretroviral therapy during lactation, it is necessary to establish drug transfer into breastmilk to determine exposure of the infant to antiretroviral drugs and potential risk of ...
Lena van der Wekken‐Pas, David Burger, Rick Greupink, Angela Colbers   +3 more
wiley   +1 more source

QuEChERS and UPLC-MS/MS-Based Quantification of Human Plasma of Eight Nucleoside Reverse Transcriptase Inhibitors and Platinum Anticancer Drugs for Hepatocellular Carcinoma. [PDF]

Molecules
Liu Y, Peng J, Liang Y, Li Y, Zhen X, Li H.   +5 more
europepmc   +1 more source

Identification of Novel Diarylpyrimidines as Potent HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors by Exploring the Primer Grip Region. [PDF]

Pharmaceuticals (Basel), 2022
Zhang T, Zhou Z, Zhao F, Sang Z, De Clercq E, Pannecouque C, Kang D, Zhan P, Liu X.   +8 more
europepmc   +1 more source

Prospects of Reverse Transcriptase Inhibitors [PDF]

, 2016
Chang Liu, Xiaohong Kong
openaire   +1 more source

Once-daily nonnucleoside reverse-transcriptase inhibitor approved [PDF]

, 1998

openalex   +1 more source

Pharmacokinetics of dolutegravir, tenofovir and lamivudine during venous–venous extracorporeal membrane oxygenation (VV‐ECMO): A case report

British Journal of Clinical Pharmacology, EarlyView.
While providing potentially life‐saving cardiorespiratory support for critically ill patients, extracorporeal membrane oxygenation (ECMO) may detrimentally affect pharmacokinetic (PK) performance and concurrent drug efficacy and safety. We describe a patient with Pneumocystis jirovecii pneumonia (PJP) in the context of acquired immunodeficiency ...
Tom C. Zwart, Emiel Leegwater, Thomas H. Ottens, Emile F. Schippers, Erik B. Wilms, David M. Burger, Cees van Nieuwkoop, Liesbeth B. E. Bosma   +7 more
wiley   +1 more source

Design and synthesis of N1-aryl-benzimidazoles 2-substituted as novel HIV-1 non-nucleoside reverse transcriptase inhibitors

, 2014
Anna‐Maria Monforte, Stefania Ferro, Laura De Luca, Giuseppa Lo Surdo, Francesca Morreale, Christophe Pannecouque, Jan Balzarini, Alba Chimirri   +7 more
openalex   +1 more source

Intracellular self‐assembled nanoneedles for efficient lysosomal escape and CRISPR/Cas9 mediated gene editing

BMEMat, EarlyView.
PlaMnB was formed by cytolysin A‐tumor homing peptides (THP)‐modified bacterial membranes encapsulating the clustered regularly interspaced short palindromic repeat/CRISPR‐associated protein (CRISPR/Cas9) plasmid and manganese dioxide. THP‐containing bacterial membrane enhances PlaMnB vascular permeability and tumor targeting, and after cellular ...
Chen Zhang, Nan Zhang, Ruiqi Yang, Qian Qiu, Jiaying Huang, Jingang Liu, Silu Li, Jonathan F. Lovell, He Ren, Yumiao Zhang   +9 more
wiley   +1 more source

Reverse transcriptase activity in psoriatic lesions: effects of reverse transcriptase inhibitors on keratinocyte proliferation and differentiation

Retrovirology, 2009
Bonté Frédéric, Dumas Marc, Tesniere Anne, Molès Jean-Pierre, Guilhou J-J   +4 more
doaj   +1 more source

Drug resistance mutations to integrase inhibitors, proteinase, and reverse transcriptase inhibitors in newly diagnosed HIV-1 infections in Hebei province, China, 2018-2022. [PDF]

Front Cell Infect Microbiol
Lu X, Li Y, Liu M, Wang Y, An N, Sun D, Li Q.   +6 more
europepmc   +1 more source