Results 181 to 190 of about 206,533 (287)

Inflammatory response to retrotransposons drives tumor drug resistance that can be prevented by reverse transcriptase inhibitors. [PDF]

Proc Natl Acad Sci U S A, 2022
Novototskaya-Vlasova KA, Neznanov NS, Molodtsov I, Hall BM, Commane M, Gleiberman AS, Murray J, Haber M, Norris MD, Leonova KI, Gudkov AV.   +10 more
europepmc   +1 more source

Relationship between hTERT levels and oxidative stress in epilepsy patients

Epilepsia Open, EarlyView.
Abstract Objective Human telomerase reverse transcriptase (hTERT) is a key determinant of telomere maintenance and cellular aging. Oxidative stress plays a role in neurodegenerative processes by causing cellular damage through increased reactive oxygen species.
Muhammed Mehdi Üremiş, Deniz Tuncel Berktaş, Nuray Üremiş, Fatma İnanç Tolun   +3 more
wiley   +1 more source

In-silico identification of phytochemical compounds from various medicinal plants as potent HIV-1 non-nucleoside reverse transcriptase inhibitors utilizing molecular docking and molecular dynamics simulations. [PDF]

Biol Methods Protoc
Danladi S, Adeniyi AA, Sani ZI, Temitope A.   +3 more
europepmc   +1 more source

Structure-based design of novel heterocycle-substituted ATDP analogs as non-nucleoside reverse transcriptase inhibitors with improved selectivity and solubility. [PDF]

Acta Pharm Sin B, 2023
Zhao LM, Pannecouque C, Clercq E, Wang S, Chen FE.   +4 more
europepmc   +1 more source

Rumen Mycobiome Thiamine Metabolism Contributes to Subacute Rumen Acidosis Tolerance in Goats Through Enhancing Epithelial Cell Proliferation via IGFBP2/IGF1 Axis Activation

Exploration, EarlyView.
Schematic illustration of the mechanism underlying the differences between SARA‐susceptible and SARA‐tolerant dairy goats fed a high‐concentrate diet. SARA‐susceptible goats (HCS) exhibit low rumen pH and metabolic decline, characterized by epithelial inflammation.
Jingyi Xu, Xiaodong Chen, Yi Ma, Jianrong Ren, Guanghao Xu, Peilin Zhang, Wenhao Jia, Quanqiu Deng, Yuquan Xiao, Junhu Yao, Shengru Wu   +10 more
wiley   +1 more source

An Exploratory Pharmacogenetic Pilot Study of Two Reverse Transcriptase Inhibitors, Tenofovir Alafenamide Fumarate and Tenofovir Disoproxil Fumarate. [PDF]

Drugs R D
Murrell DE, Kennard BC, Bertoni ME, Cluck DB, Moorman JP, Brown SD, Wang K, Duffourc MM, Harirforoosh S.   +8 more
europepmc   +1 more source

Multi‐Cohort Analysis Reveals Genetic Predispositions to Clonal Hematopoiesis as Mutation‐Specific Risk Factors for Stroke

Advanced Genetics, Volume 6, Issue 1, March 2025.
This study comprehensively evaluated the differential effect of clonal hematopoiesis (CH) mutations on the risk of various stroke subtypes and functional recovery. It shows that TET2 is associated with small vessel stroke possibly via a pro‐inflammatory pathway. Abstract Recent observational studies have found an association between Clonal Hematopoesis
Shuyang Lin, Yang E. Li, Yan Wang
wiley   +1 more source

Discovery of Dual Targeting GSK-3β/HIV-1 Reverse Transcriptase Inhibitors as Neuroprotective Antiviral Agents. [PDF]

ACS Chem Neurosci
Jones T, Raman R, Puhl AC, Lane TR, Riabova O, Kazakova E, Makarov V, Ekins S.   +7 more
europepmc   +1 more source

Identification of Boronate-Containing Diarylpyrimidine Derivatives as Novel HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors. [PDF]

Molecules, 2022
Feng D, Lin H, Jiang L, Wang Z, Sun Y, Zhou Z, Clercq E, Pannecouque C, Kang D, Zhan P, Liu X.   +10 more
europepmc   +1 more source

Synthesis of novel N1 functionalized diazepinone analogues <i>via</i> a base-mediated C-N cross coupling reaction as reverse transcriptase inhibitors: theoretical and experimental investigations. [PDF]

RSC Adv
Jaiswal S, Jain S, Mukhija A, Verma K, Jain S, Kishore D, Dwivedi J, Sharma S.   +7 more
europepmc   +1 more source