Results 201 to 210 of about 131,732 (302)

High prevalence of reverse transcriptase inhibitors associated resistance mutations among people living with HIV on dolutegravir-based antiretroviral therapy in Francistown, Botswana. [PDF]

J Antimicrob Chemother
Choga OT, Lemogang GM, Choga WT, Muzanywa G, Shadreck TM, Ralegoreng C, Maruapula D, Moraka NO, Koofhethile CK, Mokgethi PT, Seru K, Zuze BJL, Montshosi P, Gobe I, Motswaledi MS, Musonda R, Mbulawa MB, Makhema J, Shapiro R, Lockman S, Chebani T, Nawa J, Bochena L, Moyo S, Gaseitsiwe S.   +24 more
europepmc   +1 more source

RNA degradomics and proteomics reveal the mechanism of dsProsβ1‐mediated proteasome targeting in Psylliodes chrysocephala

Pest Management Science, EarlyView.
RNA degradomics revealed dsProsβ1‐derived siRNA‐mediated mRNA cleavage events, mainly at uracil‐guanine and adenine‐adenine pairs. Proteasome inhibition via dsProsβ1 increased mitochondrial and cytoskeletal proteins while reducing translation‐related and mRNA‐binding proteins.
Doga Cedden, Gözde Güney, Michael Rostás, Stefan Scholten   +3 more
wiley   +1 more source

Clinical benefits of novel non-nucleoside reverse transcriptase inhibitors: A prospective cohort study. [PDF]

Immun Inflamm Dis
Ma S, Xie X, Fu Y, Gan L, Yang X, Kong L, Li J, Long H.   +7 more
europepmc   +1 more source

First genome sequence of a European Alternaria brassicae isolate and genes involved in early development of alternaria leaf spot on Brassica juncea

Pest Management Science, EarlyView.
This article reports the first genome sequence of a UK Alternaria brassicae isolate. Dual RNA‐sequencing profiling of A. brassicae‐infected Brassica juncea leaves identified differentially expressed genes involved in pathogenicity and host response pathways in moderately resistant Sej‐2 (2) and moderately susceptible Pusa Jaikisan cultivars.
Kevin M. King, Graham McLaughlin, Chinthani S. Karandeni Dewage, Zedi Gao, David J. Hughes, Jonathan S. West, Henrik U. Stotz   +6 more
wiley   +1 more source

Nucleoside Reverse Transcriptase Inhibitors Are the Major Class of HIV Antiretroviral Therapeutics That Induce Neuropathic Pain in Mice. [PDF]

Int J Mol Sci
Bush K, Wairkar Y, Tang SJ.
europepmc   +1 more source

Synthetic polymer nanocarrier enhances dsRNA stability but not RNAi efficacy in Brassicogethes aeneus

Pest Management Science, EarlyView.
Experimental setup for dsRNA feeding in Brassicogethes aeneus to evaluate the effect of a synthetic polymer nanocarrier on RNAi efficiency. The experiment assessed whether the nanocarrier enhances RNAi after oral dsRNA delivery. (a) Stability of dsRNA–nanocarrier complexes was tested in simulated gut conditions. (b) Gene expression of αCOP and dre4 was
Triin Kallavus, Liina Soonvald, Iris Callewaert, Ana Isabel Silva, Ericmar Ávila Dos Santos, Silva Vilumets, Riina Kaasik, Sven Vereecken, Lenny Van Daele, Peter Dubruel, Jonathan Willow, Clauvis Nji Tizi Taning, Kristof De Schutter, Eve Veromann   +13 more
wiley   +1 more source

Association between the CYP2B6 polymorphisms and nonnucleoside reverse transcriptase inhibitors drug-induced liver injury: a systematic review and meta-analysis. [PDF]

Sci Rep
Chanhom N, Sonjan J, Inchai J, Udomsinprasert W, Chaikledkaew U, Suvichapanich S, Mahasirimongkol S, Jittikoon J.   +7 more
europepmc   +1 more source

Temporal dynamics of co‐inoculation of Leptosphaeria maculans and Leptosphaeria biglobosa determine interspecific competition and disease development on oilseed rape

Pest Management Science, EarlyView.
This study provides evidence that the timing of co‐inoculation of Leptosphaeria maculans and Leptosphaeria biglobosa determine the outcome of interspecific competition and disease development on their host oilseed rape. Abstract BACKGROUND Phoma stem canker is one of the most economically damaging diseases of oilseed rape, caused by co‐existing fungal ...
Evren Bingol, Chinthani S. Karandeni Dewage, Aiming Qi, Faye Ritchie, Bruce DL Fitt, Yong‐Ju Huang   +5 more
wiley   +1 more source

Bioisosterism-driven design of orally active, safe, and broad-spectrum biphenyl-DAPY derivatives as highly potent HIV-1 non-nucleoside reverse transcriptase inhibitors. [PDF]

Acta Pharm Sin B
Chen XM, Hao QQ, Pannecouque C, De Clercq E, Wang S, Chen FE.   +5 more
europepmc   +1 more source

Transcriptome Inference and Systematic Approaches to Investigate TCM Compounds With Beneficial Metabolic Effects

Phytotherapy Research, EarlyView.
ABSTRACT Obesity is a major risk factor for type 2 diabetes. Some traditional Chinese medicine (TCM) compounds can improve obesity by increasing energy consumption. This study aimed to identify and verify TCM compounds that promote adipose thermogenesis to alleviate obesity via transcriptomic analysis, molecular docking, network pharmacology, and ...
Jing Li, Yang‐Chi‐Dung Lin, Hsi‐Yuan Huang, Jihang Chen, Huali Zuo, Yun Tang, Hsien‐Da Huang   +6 more
wiley   +1 more source