Results 201 to 210 of about 1,271,708 (300)

High prevalence of reverse transcriptase inhibitors associated resistance mutations among people living with HIV on dolutegravir-based antiretroviral therapy in Francistown, Botswana. [PDF]

J Antimicrob Chemother
Choga OT, Lemogang GM, Choga WT, Muzanywa G, Shadreck TM, Ralegoreng C, Maruapula D, Moraka NO, Koofhethile CK, Mokgethi PT, Seru K, Zuze BJL, Montshosi P, Gobe I, Motswaledi MS, Musonda R, Mbulawa MB, Makhema J, Shapiro R, Lockman S, Chebani T, Nawa J, Bochena L, Moyo S, Gaseitsiwe S.   +24 more
europepmc   +1 more source

EE2 and the Fish Brain: Age‐Dependent Impact of 17α‐Ethinylestradiol on Brain Cell Proliferation and Behavior in Sea Bass Larvae

Environmental Toxicology, EarlyView.
ABSTRACT Endocrine‐disrupting chemicals (EDCs), such as 17α‐ethinylestradiol (EE2), have raised concerns about their potential effects on aquatic organisms, particularly during early developmental stages. In this context, the study of behavioral disruption has gained considerable attention, as it may have consequences on individual fitness and ...
Soloperto Sofia, Stephanie Olivier, Céline Thomasse, Christophe Minier, Marie‐Pierre Halm‐Lemeille, Christelle Jozet‐Alves, Salima Aroua   +6 more
wiley   +1 more source

Nucleoside Reverse Transcriptase Inhibitors Are the Major Class of HIV Antiretroviral Therapeutics That Induce Neuropathic Pain in Mice. [PDF]

Int J Mol Sci
Bush K, Wairkar Y, Tang SJ.
europepmc   +1 more source

Liquid biopsy in genitourinary oncology: Current clinical applications and future prospects across prostate, bladder, and renal cancers

UroPrecision, EarlyView.
Abstract Liquid biopsy has emerged as a transformative approach in oncology, providing minimally invasive access to tumor‐derived biomarkers with applications across diagnosis, prognosis, therapeutic guidance, and disease monitoring. This literature review synthesizes evidence from 125 studies evaluating circulating tumor DNA, circulating tumor cells ...
Kirolos Eskandar
wiley   +1 more source

Association between the CYP2B6 polymorphisms and nonnucleoside reverse transcriptase inhibitors drug-induced liver injury: a systematic review and meta-analysis. [PDF]

Sci Rep
Chanhom N, Sonjan J, Inchai J, Udomsinprasert W, Chaikledkaew U, Suvichapanich S, Mahasirimongkol S, Jittikoon J.   +7 more
europepmc   +1 more source

Transposons as Tools for Future Genome Engineering in Yeasts and Filamentous Fungi

Yeast, EarlyView.
Applications of transposon‐based tools for genome engineering in fungi include transposon‐mediated mutagenesis and targeted genomic integration. ABSTRACT Transposons are fundamental genetic elements that have profoundly shaped the architecture of eukaryotic genomes.
Bingyin Peng, Masahiro Tominaga, Chengqiang Wang, Robert E. Speight, Jun Ishii   +4 more
wiley   +1 more source

Bioisosterism-driven design of orally active, safe, and broad-spectrum biphenyl-DAPY derivatives as highly potent HIV-1 non-nucleoside reverse transcriptase inhibitors. [PDF]

Acta Pharm Sin B
Chen XM, Hao QQ, Pannecouque C, De Clercq E, Wang S, Chen FE.   +5 more
europepmc   +1 more source

Naturally Occurring ZCCHC3 Variants Modulate Antiretroviral Activity in Cynomolgus Macaques

Microbiology and Immunology, EarlyView.
ABSTRACT Many mammalian cells restrict viral replication by utilizing various host restriction factors. We recently demonstrated that CCHC‐type zinc‐finger‐containing protein 3 (ZCCHC3) suppresses human immunodeficiency virus type 1 (HIV‐1) replication through multiple mechanisms.
Jacob Fadipe, Tomotaka Okamura, Shige H. Yoshimura, Akatsuki Saito   +3 more
wiley   +1 more source

An Amazing 30-Year Journey around the DABO Family: A Medicinal Chemistry Lesson on a Versatile Class of Non-nucleoside HIV-1 Reverse Transcriptase Inhibitors. [PDF]

J Med Chem
Fabbrizi E, Chernyshov VV, Fiorentino F, Sbardella G, Ragno R, Nawrozkij M, Ivanov R, Rotili D, Mai A.   +8 more
europepmc   +1 more source

Calcitonin‐like diuretic hormone influences reproduction in adult female Rhodnius prolixus

Insect Science, EarlyView.
Highlights • CT/DH‐like immunoreactivity is present in female reproductive tissues • CT/DH receptor transcripts are expressed in the fat body and ovaries • RNAi knockdown of CT/DH receptors reduces egg number and hatching rate • Rhopr‐CT/DH increases RhoprVg1 and RhoprVgR expression in ovaries in vitro • Rhopr‐CT/DH stimulates oviduct contractions in a
Areej N. Al‐Dailami, Ian Orchard, Angela B. Lange   +2 more
wiley   +1 more source