Results 271 to 280 of about 399,014 (392)

Profiling the Interaction between Human Serum Albumin and Clinically Relevant HIV Reverse Transcriptase Inhibitors. [PDF]

Viruses
Costa-Tuna A, Chaves OA, Almeida ZL, Cunha RS, Pina J, Serpa C.   +5 more
europepmc   +1 more source

The Omics‐Driven Machine Learning Path to Cost‐Effective Precision Medicine in Chronic Kidney Disease

PROTEOMICS, EarlyView.
ABSTRACT Chronic kidney disease (CKD) poses a significant and growing global health challenge, making early detection and slowing disease progression essential for improving patient outcomes. Traditional diagnostic methods such as glomerular filtration rate and proteinuria are insufficient to capture the complexity of CKD.
Marta B. Lopes, Roberta Coletti, Flore Duranton, Griet Glorieux, Mayra Alejandra Jaimes Campos, Julie Klein, Matthias Ley, Paul Perco, Alexia Sampri, Aviad Tur‐Sinai   +9 more
wiley   +1 more source

Selective Interaction of the Human Immunodeficiency Virus Type 1 Reverse Transcriptase Nonnucleoside Inhibitor Efavirenz and Its Thio-Substituted Analog with Different Enzyme-Substrate Complexes

, 2000
Giovanni Maga, Daniela Ubiali, Raul Salvetti, Massimo Pregnolato, Silvio Spadari   +4 more
openalex   +1 more source

The pharmacokinetics of methadone in HIV‐positive patients receiving the non‐nucleoside reverse transcriptase inhibitor efavirenz [PDF]

, 2001
S Clarke, Fiona Mulcahy, John Tjia, Helen Reynolds, Sara E. Gibbons, Michael Barry, David Back   +6 more
openalex   +1 more source

Reverse transcriptase inhibitors prevent liver abscess formation during Escherichia coli bloodstream infection. [PDF]

Proc Natl Acad Sci U S A
Hullahalli K, Dailey KG, Hasegawa Y, Johnson WE, Waldor MK.   +4 more
europepmc   +1 more source

Update on Gene Therapy in the Treatment of Hereditary Hearing Loss

Sensory Neuroscience, EarlyView.
Gene therapy is a promising therapeutic approach for genetic disorders, including three major gene therapy strategies: gene replacement, gene suppression, and gene editing. After transmitting genes to the inner ear through appropriate pathways, repair the cochlea in order to achieve the goal of treating hereditary hearing loss.
Weiwei He, Shanying Han, Xinghong Liu, Xiaotong Huang, Wen Yang, Xinghua Tang, Chuan Dong, Jiangang Fan   +7 more
wiley   +1 more source

Salvage therapy with abacavir plus a non-nucleoside reverse transcriptase inhibitor and a protease inhibitor in heavily pre-treated HIV-1 infected patients

, 2000
Nina Khanna, Thomas Klimkait, Véronique Schiffer, Jose Irigoyen, Amalio Telenti, Hans H. Hirsch, Manuel Battegay   +6 more
openalex   +1 more source

Nature Inspired Delivery Vehicles for CRISPR‐Based Genome Editing

Small, EarlyView.
The review highlights nature‐inspired nanocarriers for CRISPR delivery, emphasizing viral vectors, extracellular vesicles, liposomes, and lipid nanoparticles. It discusses their roles in improving specificity, minimizing immunogenicity, and overcoming barriers in genome editing. Recent advancements, challenges, and therapeutic applications are explored,
Elizabeth Maria Clarissa, Mamata Karmacharya, Hyunmin Choi, Sumit Kumar, Yoon‐Kyoung Cho   +4 more
wiley   +1 more source

Safety and Pharmacokinetics of Single Doses of (+)-Calanolide A, a Novel, Naturally Occurring Nonnucleoside Reverse Transcriptase Inhibitor, in Healthy, Human Immunodeficiency Virus-Negative Human Subjects [PDF]

, 2001
Terri Creagh, Jon Ruckle, Dwain T. Tolbert, Jeremy Giltner, David Eiznhamer, Bipul Dutta, Michael T. Flavin, Ze‐Qi Xu   +7 more
openalex   +1 more source

Systemic Brain Delivery of Oligonucleotide Therapeutics Enhanced by Protein Corona‐Assisted DNA Cubes

Small Methods, EarlyView.
In vivo, screening of DNA nanostructures yields a cube‐shaped structure (D‐Cb) as a protein corona‐assisted platform for brain delivery of oligonucleotide therapeutics. D‐Cb effectively delivers polo‐like kinase 1 (PLK‐1) antisense oligonucleotides (ASO) to treat glioblastoma in an orthotopic mouse model, demonstrating its potential as a carrier for ...
Kyoung‐Ran Kim, Ji Hee Kang, Hien Bao Dieu Thai, Ji Hyun Back, Chengde Mao, Ji Eun Lee, Young Tag Ko, Dae‐Ro Ahn   +7 more
wiley   +1 more source