Results 161 to 170 of about 562,468 (202)
The promise of reverse vaccinology
International Health, 2015 Reverse vaccinology (RV) is a computational approach that aims to identify putative vaccine candidates in the protein coding genome (proteome) of pathogens. RV has primarily been applied to bacterial pathogens to identify proteins that can be formulated into subunit vaccines, which consist of one or more protein antigens.
Ashley I, Heinson +2 more
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Improving reverse vaccinology with a machine learning approach
Vaccine, 2011 Reverse vaccinology aims to accelerate subunit vaccine design by rapidly predicting which proteins in a pathogenic bacterial proteome are putative protective antigens. Support vector machine classification is a machine learning approach that has been applied to solve numerous classification problems in biological sciences but has not previously been ...
Bowman, Brett N. +10 more
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Two years into reverse vaccinology
Vaccine, 2003During the last century, several approaches have been used for the development of vaccines, going from the immunization with live-attenuated bacteria up to the formulation of the safer subunit vaccines. This conventional approach to vaccine development requires cultivation of the pathogen and its dissection using biochemical, immunological and ...
Mariagrazia Pizza, Rino Rappuoli
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Lessons from Reverse Vaccinology for viral vaccine design
Current Opinion in Virology, 2015 Although almost 15 years have passed since the birthdate of Reverse Vaccinology (RV), there are very limited applications of this approach to viral vaccines discovery. Undeniably, RV presents a series of advantages as it can virtually identify all potential antigens coded by a genome, irrespective of their abundance, phase of expression and ...
Bruno L. +3 more
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Reverse vaccinology: a genome-based approach for vaccine development
Expert Opinion on Biological Therapy, 2002During the last century several approaches have been followed for the development of vaccines. These include live-attenuated viruses and bacteria, killed microorganisms and the subunit vaccines [1]. With the introduction of recombinant DNA technologies, new approaches have been exploited for vaccine manufacturing. However, the major problem remains the
Mariagrazia Pizza +2 more
exaly +3 more sources
Reverse vaccinology, a genome-based approach to vaccine development
Vaccine, 2001The conventional approach to vaccine development requires cultivation of the pathogenic microorganism and its dissection using biochemical, immunological, and microbiological methods in order to identify the components important for immunity. This method, while successful in many cases, failed to provide a solution for many of those pathogens for which
Rino Rappuoli
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Drug Discovery Today, 2003
Whole-genome sequencing of bacteria and advances in bioinformatics have revolutionized the vaccinology field, leading to the identification of potential vaccine candidates without the need for cultivating the pathogen. This approach, termed "reverse vaccinology", reduces the time and cost required for the identification of candidate vaccines and ...
Marirosa, Mora +4 more
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Whole-genome sequencing of bacteria and advances in bioinformatics have revolutionized the vaccinology field, leading to the identification of potential vaccine candidates without the need for cultivating the pathogen. This approach, termed "reverse vaccinology", reduces the time and cost required for the identification of candidate vaccines and ...
Marirosa, Mora +4 more
openaire +2 more sources
Reverse Vaccinology and Genomics
Science, 2003The genomic revolution has had a dramatic effect on our ability to find new vaccine targets and develop effective vaccines.
Rino, Rappuoli, Antonello, Covacci
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Reverse vaccinology: A strategy also used for identifying potential vaccine antigens in poultry
VaccineInternational audienceVaccination of livestock plays a major role in improving animal health, welfare and productivity, but also in public health by preventing zoonotic diseases. Advances in bioinformatics and whole-genome sequencing techniques since the
Marianne Chemaly +2 more
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Current Opinion in Microbiology, 2000
Biochemical, serological and microbiological methods have been used to dissect pathogens and identify the components useful for vaccine development. Although successful in many cases, this approach is time-consuming and fails when the pathogens cannot be cultivated in vitro, or when the most abundant antigens are variable in sequence.
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Biochemical, serological and microbiological methods have been used to dissect pathogens and identify the components useful for vaccine development. Although successful in many cases, this approach is time-consuming and fails when the pathogens cannot be cultivated in vitro, or when the most abundant antigens are variable in sequence.
openaire +2 more sources