Results 171 to 180 of about 562,468 (202)

Vaccine Design by Reverse Vaccinology and Machine Learning

2021
Reverse vaccinology (RV) is the state-of-the-art vaccine development strategy that starts with predicting vaccine antigens by bioinformatics analysis of the whole genome of a pathogen of interest. Vaxign is the first web-based RV vaccine prediction method based on calculating and filtering different criteria of proteins.
Edison, Ong, Yongqun, He
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Antibiotic Resistance Determinant-Focused Acinetobacter baumannii Vaccine Designed Using Reverse Vaccinology

International Journal of Molecular Sciences, 2017
As one of the most influential and troublesome human pathogens, Acinetobacter baumannii (A. baumannii) has emerged with many multidrug-resistant strains. After collecting 33 complete A.
Yongqun He, Edison Ong
exaly   +2 more sources

Pangenomic Reverse Vaccinology

2009
It has become possible to obtain the set of potentially expressed proteins from the DNA sequence and, using a combination of computational and experimental approaches, to select a list of the potential antigens to be tested in animal models. This chapter illustrates how such an innovative process, termed “Reverse Vaccinology” and first applied to the ...
Claudio Donati, Duccio Medini, Rino Rappuoli   +2 more
openaire   +1 more source

Reverse Vaccinology and Its Applications

2020
The application of the fields of pharmacogenomics and pharmacogenetics to vaccine design, profoundly combined with bioinformatics, has been recently termed "vaccinomics." The enormous amount of information generated by whole genome sequencing projects and the rise of bioinformatics has triggered the birth of a new era of vaccine research and ...
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Reverse Vaccinology in Bacillus anthracis

2010
In search for antigens which may form the basis for improved subunit or live attenuated B. anthracis vaccines, extensive genomic, proteomic and serologic analyses coupled with functional screens for surface exposed and/or secreted proteins, were carried out.
Avigdor Shafferman, Orit Gat, Naomi Ariel, Theodor Chitlaru, Haim Grosfeld, Anat Zvi, Izhak Inbar, Galia Zaide, Ronit Aloni-Grinstein, Sara Cohen   +9 more
openaire   +1 more source

The Bacterial Pan-Genome and Reverse Vaccinology

2009
The whole genome sequence of most human bacterial pathogens is available and the advent of next-generation sequencing technologies will result in a large number of sequenced isolates per pathogenic species. The study of multiple genome sequences of a given bacterium provides insights into its evolution, pathogenic potential and diversity.
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Conjugates and reverse vaccinology to eliminate bacterial meningitis

Vaccine, 2001
Bacterial meningitis is caused mainly by Haemophilus influenzae, Streptococcus pneumoniae and Neisseria meningitidis. Haemophilus influenzae type b vaccines have been extremely successful in eradicating the disease from those countries where the vaccine has been introduced.
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Reverse vaccinology: From genome to vaccine

2002
Publisher Summary This chapter describes the first vaccine project to take this approach that has led to the definition of a completely new paradigm of more general use in developing the next generation of vaccines for which the traditional approaches have failed. The availability of complete genome sequence information on many pathogens has led to a
John L. Telford, Mariagrazia Pizza, Guido Grandi, Rino Rappuoli   +3 more
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Reverse Vaccinology and Vaccines for Serogroup B Neisseria meningitidis

2007
Whole genome sequence data are increasingly available for a wide range of human pathogens. The use of bioinformatic tools allows the comprehensive in silico screening of genome data for surface-expressed proteins, in order to identify candidate vaccine antigens.
Dominic F, Kelly, Rino, Rappuoli
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Reverse vaccinology — In search of a genome-derived meningococcal vaccine

Vaccine, 2006
Although significant advances have been made toward the control of bacterial meningitis in children with the development of capsular polysaccharide protein conjugate vaccines, this approach has proven problematic for the serogroup B meningococcus. Non-capsular vaccines based upon outer membrane vesicles of Neisseria meningitidis have been useful in ...
openaire   +2 more sources