Results 71 to 80 of about 21,282,199 (350)
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
FEBS Letters, EarlyView.Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
FEBS Letters, EarlyView.Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
معیارهای تعیینکننده بیمارستان سبز: مرور حوزهای
مدیریت اطلاعات سلامت, 2020 مقدمه: بیمارستان سبز در جهت صرفهجویی منابع و انرژی، منجر به افزایش رقابتپذیری، بهرهوری و کاهش هزینهها میگردد. پژوهش حاضر با هدف شناسایی و دستهبندی معیارهای تعیینکننده بیمارستان سبز انجام شد.
Diba Norozi +2 more
doaj +1 more source
Management of anastomotic leakage after rectal surgery: a review article.
Journal of Gastrointestinal Oncology, 2019 Anastomotic leaks (ALs) are associated with increased perioperative morbidity and mortality, prolonged length of stay, higher readmission rates, the potential need for further operative interventions, and unintended permanent stomas; resulting in ...
Y. Tsai, W. Chen
semanticscholar +1 more source
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
Lihavuus terveyden, sairauden ja normaaliuden määrittelyn kohteena
J@rgonia, 2018 Lihavuudesta ja lihavasta ruumiista on tullut viimeistään viime vuosikymmenen niin kutsutun lihavuusepidemiadiskurssin myötä keskeinen paitsi lääketieteellisen myös sosiaalisen ja moraalisen arvioinnin, yhteiskunnallisen keskustelun ja toimintaohjelmien ...
Hannele Harjunen
doaj
Review article: dietary fibre in the era of microbiome science
Alimentary Pharmacology and Therapeutics, 2019 Explanations for the health benefits of dietary fibre have, in the past, been inconsistent and studies of the physiological effects of dietary fibre were, perhaps, directed at the wrong read‐outs.
J. O’Grady, E. O'Connor, F. Shanahan
semanticscholar +1 more source