Results 71 to 80 of about 4,949 (187)
Stem Cell Research, 2023 Cerebellar ataxia, neuropathy, and vestibular areflexia syndrome (CANVAS) is a progressive neurodegenerative disorder predominantly caused by biallelic AAGGG expansions in the second intron of the RFC1 gene. Here, we used a simultaneous reprogramming and
Kayli C. Davies +2 more
doaj +1 more source
A conserved Polϵ binding module in Ctf18-RFC is required for S-phase checkpoint activation downstream of Mec1 [PDF]
, 2015 Defects during chromosome replication in eukaryotes activate a signaling pathway called the S-phase checkpoint, which produces a multifaceted response that preserves genome integrity at stalled DNA replication forks.
Bentley +9 more
core +4 more sources
Cellular Stress, Inflammation and Barrier Damage in Gut Epithelial Cells Caused by Aspartame
Allergy, Volume 81, Issue 3, Page 884-901, March 2026.This study shows that aspartame, at dietary‐relevant doses, induces cytotoxicity, cellular distress associated with endoplasmic reticulum stress, oxidative stress, DNA replication and repair mechanism disturbance culminating in epithelial barrier damage.
Yagiz Pat +16 more
wiley +1 more source
Characterization of the five replication factor C genes of Saccharomyces cerevisiae [PDF]
, 1995 Replication factor C (RFC) is a five-subunit DNA polymerase accessory protein that functions as a structure-specific, DNA-dependent ATPase. The ATPase function of RFC is activated by proliferating cell nuclear antigen.
Cullmann, G. +3 more
core
Identification of Elg1 interaction partners and effects on post-replication chromatin re-formation [PDF]
, 2018 We thank members of the Donaldson, Kubota, and Lorenz labs for helpful discussion, Sophie Shaw at the University of Aberdeen for data upload to Array Express and Shin-ichiro Hiraga for help with Bioinformatic analysis.
Dickerson, David +7 more
core +4 more sources
CANVAS with cerebellar/sensory/vestibular dysfunction from RFC1 intronic pentanucleotide expansion [PDF]
Brain, 2020 This scientific commentary refers to ‘Cerebellar ataxia, neuropathy, vestibular areflexia syndrome due to RFC1 repeat expansion’, by Cortese et al. (doi: 10.1093/brain/awz418).
Coro, Paisán-Ruiz, Joanna C, Jen
openaire +2 more sources
BMC Cancer, 2017 Background We investigated whether GSTT1 (“null” allele), GSTM1 (“null”allele), GSTP1 (A313G), RFC1 (G80A), MTHFR (C677T), TS (2R/3R) polymorphisms were associated with toxicity and survival in patients with early breast cancer (EBC) treated with ...
Vienna Ludovini +15 more
doaj +1 more source
Somatic mutation load of estrogen receptor-positive breast tumors predicts overall survival: an analysis of genome sequence data. [PDF]
, 2014 Breast cancer is one of the most commonly diagnosed cancers in women. While there are several effective therapies for breast cancer and important single gene prognostic/predictive markers, more than 40,000 women die from this disease every year.
Bainbridge, Matthew N +3 more
core +1 more source
Cell Proliferation, Volume 59, Issue 3, March 2026.PIK‐III enhancing the efficacy of cuproptosis to kill renal cancer cells through dysregulating thiamine metabolism and dephosphorylation of pyruvate dehydrogenase complex E1 (PDHA1), providing a potential option for treatment of cuproptosis‐resistant renal cancer by the combination of PIK‐III and elesclomol.
Dongdong Xie +8 more
wiley +1 more source
Advanced Science, Volume 13, Issue 12, 27 February 2026.Multiomic profiling of HER2‐low breast cancer identifies three proteomic subtypes with distinct therapeutic strategies: endocrine, antiangiogenic, and anti‐HER2 therapies. Genomic and lactate modification landscapes are detailed, providing insights for precise management.
Shouping Xu +20 more
wiley +1 more source