Association of reduced folate carrier-1 (RFC-1) polymorphisms with ischemic stroke and silent brain infarction. [PDF]
PLoS ONE, 2015 Stroke is the second leading cause of death in the world and in South Korea. Ischemic stroke and silent brain infarction (SBI) are complex, multifactorial diseases influenced by multiple genetic and environmental factors.
Yunkyung Cho +9 more
doaj +3 more sources
Xenopus reduced folate carrier regulates neural crest development epigenetically. [PDF]
PLoS ONE, 2011 Folic acid deficiency during pregnancy causes birth neurocristopathic malformations resulting from aberrant development of neural crest cells. The Reduced folate carrier (RFC) is a membrane-bound receptor for facilitating transfer of reduced folate into ...
Jiejing Li +4 more
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Reduced folate carrier 1 is present in retinal microvessels and crucial for the inner blood retinal barrier integrity [PDF]
Fluids and Barriers of the CNS, 2023 Background Reduced folate carrier 1 (RFC1; SLC19a1) is the main responsible transporter for the B9 family of vitamins named folates, which are essential for normal tissue growth and development.
Gokce Gurler +6 more
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Ischemia-Reperfusion Injury Reduces Kidney Folate Transporter Expression and Plasma Folate Levels [PDF]
Frontiers in Immunology, 2021 Acute or chronic kidney disease can cause micronutrient deficiency. Patients with end-stage renal disease, kidney transplantation or on dialysis have reduced circulating levels of folate, an essential B vitamin.
Cheng Yang +17 more
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Reduced folate carrier 1 G80A polymorphism is correlated with elevated methotrexate-induced toxicity in pediatric acute lymphoblastic leukemia patients: a systemic meta-analysis [PDF]
World Journal of Surgical OncologyBackground Reduced folate carrier 1 (RFC1) is an important solute carrier transporter crucial for the uptake and transport of methotrexate (MTX). This meta-analysis aimed to systemically analyze the relationship between the RFC1 G80A polymorphism and MTX-
Yihuan Yue +3 more
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The study of association between reduced folate carrier 1 (RFC1) polymorphism and non-syndromic cleft lip/palate in Iranian population [PDF]
BioImpacts, 2017 Introduction: Cleft lip/palate is one of the most common congenital defects and is supposed to have multifactorial etiology, including a complex interaction between genetics and environment.
Behnoosh Soghani +5 more
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Post-transcriptional regulation of the human reduced folate carrier as a novel adaptive mechanism in response to folate excess or deficiency [PDF]
Bioscience Reports, 2014 The RFC (reduced folate carrier) is the principal mechanism by which folates and clinically used antifolates are delivered to mammalian cells. hRFC (human RFC) is subject to complex transcriptional controls and exists as homo-oligomer.
Zhanjun Hou +2 more
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Regulation of Reduced Folate Carrier (RFC) by Vitamin D Receptor at the Blood-Brain Barrier. [PDF]
Mol Pharm, 2017 Alam C +4 more
europepmc +2 more sources
Biochemical and molecular mechanisms of folate transport in rat pancreas; interference with ethanol ingestion. [PDF]
PLoS ONE, 2011 Folic acid is an essential nutrient that is required for one-carbon biosynthetic processes and for methylation of biomolecules. Deficiency of this micronutrient leads to disturbances in normal physiology of cell.
Nissar Ahmad Wani +2 more
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Heliyon, 2021 Cancer is one of the main causes of human mortality worldwide and novel chemotherapeutics are required due to the limitations of conventional cancer therapies.
Ali Razaghi +4 more
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