Results 41 to 50 of about 4,058,802 (278)

Role of folate metabolizing genes and homocysteine in mothers of Down syndrome children

Tzu Chi Medical Journal, 2022
Objectives: Folates are essential nutrients required for the synthesis of DNA/RNA in cell division and segregation. Folates are reduced and methylated in the liver with the help of enzymes such as methylenetetrahydrofolate reductase (MTHFR), MTR MTRR ...
Amandeep Kaur, Anupam Kaur
doaj   +1 more source

Folate receptor and human reduced folate carrier expression in HepG2 cell line exposed to fumonisin B1 and folate deficiency [PDF]

Carcinogenesis, 2007
Fumonisin B1 (FB1) induces apoptosis and decreases the cellular uptake of 5-methyltetrahydrofolate. Two folate transporters (folate receptor, FR, and Reduced Folate Carrier, hRFC1) are involved in the cell uptake of folate. We aimed to study whether FB1 modifies the expression of the FR and the hRFC1 and whether its apoptotic effect is influenced by ...
Afif M, Abdel Nour, Diana, Ringot, Jean-Louis, Guéant, Abalo, Chango   +3 more
openaire   +2 more sources

Microbial Metabolic Capacity for Intestinal Folate Production and Modulation of Host Folate Receptors

Frontiers in Microbiology, 2019
Microbial metabolites, including B complex vitamins contribute to diverse aspects of human health. Folate, or vitamin B9, refers to a broad category of biomolecules that include pterin, para-aminobenzoic acid (pABA), and glutamate subunits.
Melinda A. Engevik, Melinda A. Engevik, Christina N. Morra, Christina N. Morra, Daniel Röth, Kristen Engevik, Jennifer K. Spinler, Jennifer K. Spinler, Sridevi Devaraj, Sridevi Devaraj, Sue E. Crawford, Mary K. Estes, Mary K. Estes, Markus Kalkum, Markus Kalkum, James Versalovic, James Versalovic   +16 more
doaj   +1 more source

Association of methylenetetrahydrofolate reductase C677T and reduced-f carrier-1 G80A gene polymorphism with preeclampsia in Sudanese women

Hypertension in Pregnancy, 2020
Purpose To assess the associations between preeclampsia, methylenetetrahydrofolate reductase (MTHFR) C677T, and reduced folate carrier-1 (RFC-1) G80A gene polymorphism in Sudanese women.
Sumia F. Ahmed, Mohamed M. Ali, Sumeya Kheiri, Salah Eldin G. Elzaki, Ishag Adam   +4 more
doaj   +1 more source

Reduced folate carrier polymorphism determines methotrexate uptake by B cells and CD4+ T cells

, 2008
To examine if polymorphism 80G --> A in the Reduced Folate Carrier (RFC) affects uptake of MTX in B- and CD4+ T ...
Baslund, B, Gregers, Jannie,, Nielsen, C H,, Gregers, J, Baslund, B,, Nielsen, Claus Henrik   +5 more
core   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Reduced folate carrier polymorphism (80A→G) and neural tube defects [PDF]

European Journal of Human Genetics, 2003
Transport of folates in mammalian cells occurs by a carrier-mediated mechanism. The human folate carrier (RFC-1) gene has been isolated and characterized. Within this gene, a common polymorphism, 80A-->G, changing a histidine to an arginine in exon 2 (H27R), was recently identified.
De Marco, Patrizia, Calevo, Maria Grazia, Moroni, Anna, Merello, Elisa, Raso, Alessandro, Finnell, Richard H., Zhu, Huiping, Andreussi, Luciano, Cama, Armando, Capra, Valeria   +9 more
openaire   +2 more sources

Potential Use of Folate-polyethylene glycol (PEG)-Appended Dendrimer (G3) Conjugate with alpha-Cyclodextrin as DNA Carriers to Tumor Cells [PDF]

, 2011
We previously reported that polyamidoamine STARBURST dendrimer (generation 3, G3) (dendrimer) conjugate with alpha-cyclodextrin (alpha-CyD) having an average degree of substitution of 2.4 of alpha-CyD (alpha-CDE) provided remarkable aspects as novel ...
Masayo Arizono, Fumitoshi Hirayama, Hidetoshi Arima, Haruna Ikeda, Tomoko Takeuchi, Kaneto Uekama, Taishi Higashi, Ayumi Yoshimitsu, Kenjiro Hattori, Keiichi Motoyama   +9 more
core  

Juvenile Huntington Disease With Cerebellar‐Predominant Atrophy Identified by Genome Sequencing

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Juvenile Huntington disease accounts for a small fraction of Huntington disease cases and is driven by the largest trinucleotide repeat expansions. We describe a 6‐year‐old boy with progressive global regression, generalized dystonia, and epilepsy, in whom serial imaging showed striking cerebellar‐predominant atrophy with an initially normal ...
Enrique Gonzalez Saez‐Diez, Amy Tam, Siofra Carty, Monica Ferrer Socorro, Kathryn Yang, Darius Ebrahimi‐Fakhari   +5 more
wiley   +1 more source

Ligand‐Directed Molecular Beacons as Turn‐On Fluorescent Probes for Sensing Cell‐Surface Receptor‐Ligand Interactions

Angewandte Chemie, EarlyView.
Multivalent, ligand‐directed molecular beacons enable fluorescence turn‐on detection of cell‐surface receptors in living cells. The probes strongly engage closely spaced membrane receptors and exhibit conformation‐dependent fluorescence enhancement at the cell surface, enabling wash‐free receptor imaging, inhibitor screening, and functional evaluation ...
Noa Oppenheimer‐Low, Denis Shpalter, Suraj Toraskar, Martín López‐Vidal, Ziv Porat, Inna Goliand, Ekaterina Petrovich‐Kopitman, Noga Kozer, Haim Michael Barr, Alla H. Falkovich, Leila Motiei, David Margulies   +11 more
wiley   +2 more sources