Results 61 to 70 of about 4,058,802 (278)

Maternally Contributed Folate Receptor 1 Is Expressed in Ovarian Follicles and Contributes to Preimplantation Development

Frontiers in Cell and Developmental Biology, 2017
Folates have been shown to play a crucial role for proper development of the embryo as folate deficiency has been associated with reduced developmental capacity such as increased risk of fetal neural tube defects and spontanous abortion.
Trine Strandgaard, Solveig Foder, Anders Heuck, Erik Ernst, Morten S. Nielsen, Morten S. Nielsen, Karin Lykke-Hartmann, Karin Lykke-Hartmann, Karin Lykke-Hartmann   +8 more
doaj   +1 more source

Functional Role of Arginine 373 in Substrate Translocation by the Reduced Folate Carrier [PDF]

Journal of Biological Chemistry, 2002
The reduced folate carrier (RFC) plays a critical role in the cellular uptake of folates. However, little is known regarding the mechanism used to transport substrates or the tertiary structure of the protein. Through the analysis of a Chinese hamster ovary cell line deficient in folate uptake, we have identified a single residue in TM10 (Arg-373) of ...
Heather, Sadlish, Frederick M R, Williams, Wayne F, Flintoff   +2 more
openaire   +2 more sources

TROP2‐Targeting Chimeras (TRTACs) for Tumor Cell‐Selective Membrane Protein Degradation and Enhanced Drug Delivery

Advanced Science, EarlyView.
TROP2 is identified as a novel tumor‐selective lysosomal‐targeting receptor with established clinical relevance. TROP2‐targeting chimeras (TRTACs) are developed by genetically fusing a TROP2‐binding nanobody to nanobodies against specific target proteins.
Luping Chen, Xinying Fu, Wenqian Dong, Xiaobei Deng, Simin Chen, Fujun Wang, Jian Zhao, Shiqun Shao, Liqiang Fan, Jingyu Zhang, Lixin Zhang   +10 more
wiley   +1 more source

Context‐Dependent Inverse Association of Glucose–Lipid Metabolic Status With Anemia: Evidence From Multinational Multicohort Analyses

Advanced Science, EarlyView.
Across six multinational cohorts, higher triglyceride–glucose index values are consistently associated with lower prevalent and incident anemia, despite their established adverse cardiometabolic significance. This inverse relationship varies across inflammatory, cardiovascular, and renal contexts, suggesting that glucose–lipid metabolic status carries ...
Guosong Jiang, Xinxing Wang, Lianfeng Xie, Wenna Ding, Yingyong Yin, Mei Yao, Zhibo Cui, Kaiqiang Tang, Lijie Zhong, Zhi Wang, Jia Wang, Lei Lei, Xiaoxiao Qu, Chi‐E. Qiu   +13 more
wiley   +1 more source

The Proton-Coupled Folate Transporter: Impact on Pemetrexed Transport and on Antifolates Activities Compared with the Reduced Folate Carrier [PDF]

Molecular Pharmacology, 2008
The reduced folate carrier (RFC) and the proton-coupled folate transporter (PCFT) are ubiquitously expressed in normal and malignant mammalian tissues and in human solid tumor cell lines. This article addresses the extent to which PCFT contributes to transport of pemetrexed and to the activities of this and other antifolates relative to RFC at ...
Rongbao, Zhao, Andong, Qiu, Eugenia, Tsai, Michaela, Jansen, Myles H, Akabas, I David, Goldman   +5 more
openaire   +2 more sources

Receptor‐Triggered Peptide Self‐Assembly Enables Multivalent Recruitment of Endogenous Antibodies for Cancer Immunotherapy

Advanced Science, EarlyView.
Receptor‐triggered supramolecular self‐assembly converts monovalent antibody‐recruiting molecules into multivalent platforms directly on cancer cell membranes. The resulting fibrillar assemblies present clustered haptens that efficiently recruit endogenous antibodies, enabling selective complement‐mediated immune killing of EGFR‐positive cancer cells ...
Yihui Wang, Xia Wu, Chenguang Zhao, Hong Han, Wensha Xie, Dan Yuan, Junfeng Shi   +6 more
wiley   +1 more source

Effect of reduced folate carrier gene polymorphism (G80A) on the methotrexate level in patients with rheumatoid arthritis and it’s relation to the disease activity

Science Journal of University of Zakho
Methotrexate (MTX) is the primary conventional synthetic disease-modifying anti-rheumatic drug (csDMARD) used to treat rheumatoid arthritis (RA).
Rozheen Jaafar, Adil Eissa
doaj   +1 more source

Folate receptor alpha and reduced folate carrier in ovarian cancer

, 2012
published_or_final_version ; Pathology ; Master ; Master of Medical ...
openaire   +2 more sources

BRCA1 Mutation‐Recognizing Tetrahedral Framework Nucleic Acid Nanoplatform Enables Coordinated PARP/WEE1 Inhibition and STING‐Associated Antitumor Immunity in Ovarian Cancer

Advanced Science, EarlyView.
BRCA1 mutation‐responsive FBOA‐tFNA selectively recognizes mutant transcripts and coordinates reduction‐responsive intracellular delivery of olaparib and adavosertib, amplifying DNA damage and weakening G2/M checkpoint protection. These effects are accompanied by STING‐associated immune activation and stronger antitumor immunity, while sequential anti ...
Chenyi Wang, Mengying Yao, Jinhui Xie, Dingjie Wang, Yashi Shi, Xiaodan Mao, Chunhua Lu, Pengming Sun   +7 more
wiley   +1 more source

Association of Folate Receptor (Folr1, Folr2, Folr3) and Reduced Folate Carrier (Slc19A1) Genes With Meningomyelocele [PDF]

, 2010
BACKGROUND: Meningomyelocele (MM) results from lack of closure of the neural tube during embryologic development. Periconceptional folic acid supplementation is a modifier of MM risk in humans, leading toan interest in the folate transport genes as ...
O\u27Byrne, Michelle R, Kit Sing Au, Kathryn K. Ostermaier, Hope Northrup, Tyerman, Gayle H, Lin, Jone-Ing, Fletcher, Jack M, Au, Kit Sing, Sabine Doebel, Northrup, Hope, Gayle H. Tyerman, Jack M. Fletcher, Ostermaier, Kathryn K, Doebel, Sabine, Alanna C. Morrison, Michelle R. O'Byrne, Morrison, Alanna C, Jone-Ing Lin   +17 more
core   +1 more source