Results 81 to 90 of about 4,058,802 (278)

Gut Health in Ostriches (Struthio camelus): Insights Into Intestinal Structure, Functions, Microbiome, and Improvement Strategies

Animal Research and One Health, EarlyView.
Our paper systematically reviews the intestinal structure, function, and microbiota of ostriches, along with strategies for improving their gut health. We analyze how these factors collectively influence intestinal homeostasis and ostrich welfare, emphasizing probiotics as a promising intervention to enhance gut health, boost population well‐being, and
Zi‐Qun Zhang, Fang‐Fang Guo, Wen‐Juan Du, Meng Li, Aftab Shaukat, Zhu‐Qing Jia, Shu‐Cheng Huang   +6 more
wiley   +1 more source

Effect of developmental changes on pharmacokinetics of drugs used in the treatment of infant acute lymphoblastic leukaemia—A comprehensive review

British Journal of Clinical Pharmacology, EarlyView.
While the event‐free survival (EFS) of children treated for acute lymphoblastic leukaemia (ALL) has improved greatly in the last decades, the EFS for patients diagnosed with ALL before the age of one is still under 50%. This outcome further decreases when infants have a rearrangement in the gene encoding histone‐lysine N‐methyltransferase 2A (KMT2A ...
Tirsa de Kluis, Leiah J. Brigitha, Lidwien M. Hanff, Alwin D. R. Huitema, Inge M. van der Sluis, Meta H. M. Diekstra   +5 more
wiley   +1 more source

Folate System Gene Variant rs1801394 66A>G may have a Causal Role in Down Syndrome in the Eastern Indian Population [PDF]

International Journal of Molecular and Cellular Medicine, 2020
Down syndrome (DS) is associated with trisomy of the 21st chromosome in more than 95% cases. The extra chromosome mostly derives due to abnormal chromosomal segregation, i.e. non-disjunction, during meiosis.
Mahasweta Chatterjee, Tanusree Saha, Subhamita Maitra, Swagata Sinha, Kanchan Mukhopadhyay   +4 more
doaj  

Co-delivery of paclitaxel and anti-VEGF siRNA by tripeptide lipid nanoparticle to enhance the anti-tumor activity for lung cancer therapy

Drug Delivery, 2020
The combination of chemotherapeutic drug paclitaxel (PTX) and VEGF siRNA could inhibit cancer development with synergistic efficacy. However, efficient and safe delivery systems with high encapsulation efficiency of PTX and a long-time release of drugs ...
Chuanmin Zhang, Yinan Zhao, Enxia Zhang, Meilin Jiang, Defu Zhi, Huiying Chen, Shaohui Cui, Yuhong Zhen, Jingnan Cui, Shubiao Zhang   +9 more
doaj   +1 more source

Harnessing ferroptosis from multilayer defense networks to nanoplatforms for specific cancer therapy

BMEMat, EarlyView.
Nanomaterials target metabolically‐regulated ferroptosis for cancer therapy. Iron‐based or alternative nanoplatforms integrate ferroptosis with chemotherapy, immunotherapy, or radiotherapy. They enable stimulus‐responsive therapies (photothermal, photodynamic, sonodynamic) activated by near‐infrared, light, or ultrasound, achieving potent synergistic ...
Xinyue Xu, Xuejian Wang, Wenyan Jiang, Wan Hairul Anuar Kamaruddin, Chunyan Fang, Pengfei Zhang   +5 more
wiley   +1 more source

Cleft Lip and Palate in Vietnam and Folate-related Genes

, 2015
The etiology of nonsyndromic cleft lip with or without cleft palate (NCLP) is multifactorial, including genetic and environmental factors. Folate-related genes methylenetetrahydrofolate reductase (MTHFR) and reduced folate carrier 1 (RFC1) are among ...
Seto, Melanie, Yuen, Holly, Tolarova, Veronika, Hong, Soomin, Valley, Maureen, Ng, Nick, Tolar, Miroslav, Arslan, Fateh, Halim, Arief, Berdichevsky, Helen, Tolarová, Marie M.   +10 more
core  

Innovation of plant‐derived extracellular vesicles and interdisciplinary research: From discovery to biomedical applications

BMEMat, EarlyView.
Plant‐derived extracellular vesicles offer numerous advantages and are regarded as highly promising candidates in the field of biomedicine. Abstract Extracellular vesicles (EVs) are double‐membrane vesicular structures that can be secreted by nearly all living cells.
Zilin Li, Yi Wei, Ben Hu, Yafang Song, Xiaojia Chen, Nik Ahmad Nizam Nik Malek, Tongkai Chen   +6 more
wiley   +1 more source

ASSOCIATION OF REDUCED FOLATE CARRIER ONE GENE 80AG POLYMORPHISM WITH NONSYNDROMIC CLEFT LIP AND PALATE

, 2013
Mutations in folate pathway genes have been shown to be associated with several birth defects including neural tube defects, conotruncal heart defects, and nonsyndromic cleft lip and palate (NCLP).
Nordberg, Eric, Balghonaim, Abir, Tolarova, Maria M., Tolar, Mirek, Kozyryev, Maryna, Touni, Walied, Upadhyay, Namrata, Marwaha, Sukhmani, Ravi, Kavitha, Berdichevsky, Helen   +9 more
core  

The Effect of the MTHFR C677T Genotype Polymorphism on the Efficacy of Folic Acid Treatment for Hyperhomocysteinemia and Cardiovascular Endothelial Function

Chronic Diseases and Translational Medicine, EarlyView.
Flowchart of patient enrollment. ABSTRACT Background Cardiovascular disease remains a major public health burden. This study aimed to investigate the effect of the methylenetetrahydrofolate reductase (MTHFR) C677T genotype on folic acid treatment response and cardiovascular endothelial function in patients with hyperhomocysteinemia (HHcy).
Xiaohui Dou, Xijuan Zhang, Liang Zeng, Liheng Zeng, Xiaoyan Hu, Xuhong Jiang, Yahui Wan, Mingxia Ge, Xiaoyan Huang   +8 more
wiley   +1 more source

Folate Receptor Beta Signaling in the Regulation of Macrophage Antimicrobial Immune Response: A Scoping Review

Biomedicine Hub
Introduction: Folate, vitamin B9, is a water-soluble vitamin that is essential to cellular proliferation and division. In addition to the reduced folate carrier, eukaryotic cells take up folate through endocytosis mediated by one of two GPI-anchored ...
Anna C.C. Castelo Branco, Lisa M. Rogers, David M. Aronoff   +2 more
doaj   +1 more source