Results 31 to 40 of about 4,058,802 (278)

Stereoselectivity of the reduced folate carrier in Caco‐2 cells

Chirality, 2005
AbstractStereoselectivity of the human reduced folate carrier (RFC1) was examined in Caco‐2 cells using methotrexate (l‐amethopterin or l‐MTX) and its antipode (d‐amethopterin or d‐MTX) as model substrates. The initial uptake rate of folic acid (FA) was concentration dependent, with a Km value of approximately 0.6 μM. The Eadie–Hofstee plot of the RFC1‐
Tomoya, Narawa, Rikako, Shimizu, Shuhei, Takano, Yasuyuki, Tsuda, Kiyoko, Ono, Hideo, Yamada, Tomoo, Itoh   +6 more
openaire   +5 more sources

Folate bioavailability [PDF]

, 2009
An inadequate folate status is associated with increased risk of anaemia and neural tube defects. In many countries a folate intake below recommendations has been reported for women in childbearing age.
Öhrvik, Veronica
core   +1 more source

Paradoxical impact of two folate receptors, FRα and RFC, in ovarian cancer: effect on cell proliferation, invasion and clinical outcome.

PLoS ONE, 2012
Despite being an essential vitamin, folate has been implicated to enhance tumor growth, as evidenced by reports on overexpression of folate receptor alpha (FRα) in carcinomas.
Michelle K Y Siu, Daniel S H Kong, Hoi Yan Chan, Esther S Y Wong, Philip P C Ip, LiLi Jiang, Hextan Y S Ngan, Xiao-Feng Le, Annie N Y Cheung   +8 more
doaj   +1 more source

The Reduced Folate Carrier (SLC19A1) c.80G>A Polymorphism is associated with red cell folate concentrations among women [PDF]

, 2009
Low folate status may be a consequence of suboptimal intake, transport or cellular utilization of folate and, together with elevated homocysteine, is a recognized risk factor or marker for several human pathologies.
Young, Ian, Colin A. Boreham, Woodside, Jayne; id_orcid, Helene McNulty, Peter T. Buckley, Anna Stanisławska‐Sachadyn, McNulty, H., Whitehead, A.S., J. J. Strain, Carmel Kealey, Strain, J.J., Buckley, P.T., Liam Murray, Mitchell, L.E., Jayne V. Woodside, Laura E. Mitchell, John M. Scott, Kealey, C., Scott, J.M., Stanislawska-Sachadyn, A., Alexander S. Whitehead, Boreham, C.A., Murray, Liam, Ian S. Young   +23 more
core   +1 more source

Metabolic effects of a high-fat diet post-weaning after low maternal dietary folate during pregnancy and lactation [PDF]

, 2014
Scope Investigate the influence of low-folate supply during pregnancy and lactation on obesity and markers of the metabolic syndrome in offspring, and how provision of a high-fat diet post weaning may exacerbate the resultant phenotype.
Sabine A. S. Langie, Caroline Manus, Jill A. McKay, Mckay, Jill A., Maxwell, Ross J., Manus, Caroline, Dianne Ford, Maxwell, Ross, Long Xie, Ross J. Maxwell, Langie, Sabine A.S.; id_orcid, Xie, Long, Mathers, John C., McKay, Jill, Langie, Sabine, Ford, Dianne, John C. Mathers   +16 more
core   +1 more source

Folate-receptor-targeted co-self-assembly carrier-free gemcitabine nanoparticles loading indocyanine green for chemo-photothermal therapy

Frontiers in Bioengineering and Biotechnology, 2023
The carrier-free chemo-photothermal therapy has become a promising strategy to improve anti-cancer therapeutic efficacy owing to the combination of chemotherapy and photothermal therapy, with improved chemotherapy drug pharmacodynamics and ...
Shuang Kuang, Shuhan Liu, Shiyu Wang, Liang Yang, Yingchun Zeng, Xin Ming   +5 more
doaj   +1 more source

Folic Acid Absorption Characteristics and Effect on Cecal Microbiota of Laying Hens

Frontiers in Veterinary Science, 2021
This experiment was conducted to investigate the characteristics of folic acid (FA) absorption in laying hens and the effect of FA supplementation on cecal microbiota.
Yan Bai, Rui Wang, Rui Wang, Yu Yang, Ruirui Li, Xiaotian Wu   +5 more
doaj   +1 more source

Luteolin Enhances Choroid Plexus 5-MTHF Brain Transport to Promote Hippocampal Neurogenesis in LOD Rats

Frontiers in Pharmacology, 2022
Folates, provided by food, are commonly used antidepressant synergists in late-onset depression (LOD). However, increased intake of folic acid in the elderly population might lead to the accumulation of unmetabolized folic acid in the systemic ...
Hui-Zhen Li, Kai-Ge Liu, Ning-Xi Zeng, Xiao-Feng Wu, Wen-Jun Lu, Han-Fang Xu, Can Yan, Li-Li Wu   +7 more
doaj   +1 more source

Quantitative correlation between promoter methylation and messenger RNA levels of the reduced folate carrier

BMC Cancer, 2008
Background Methotrexate (MTX) uptake is mediated by the reduced folate carrier (RFC). Defective drug uptake in association with decreased RFC expression is a common mechanism of MTX resistance in many tumor types.
Kheradpour Albert, Banerjee Debabrata, Kim Hansoo, Hoang Bang H, Li Wei-Wei, Yang Rui, Healey John H, Meyers Paul A, Bertino Joseph R, Gorlick Richard   +9 more
doaj   +1 more source

Folate Carrier Deficiency Drives Differential Methylation and Enhanced Cellular Potency in the Neural Plate Border

Frontiers in Cell and Developmental Biology, 2022
The neural plate border (NPB) of vertebrate embryos segregates from the neural and epidermal regions, and it is comprised of an intermingled group of multipotent progenitor cells. Folate is the precursor of S-adenosylmethionine, the main methyl donor for
Nagif Alata Jimenez, Pablo H. Strobl-Mazzulla   +1 more
doaj   +1 more source