Subcellular localization and distribution of the reduced folate carrier in normal rat tissues
European Journal of Histochemistry, 2011 The reduced folate carrier (Rfc1; Slc19a1) mediated transport of reduced folates and antifolate drugs such as methotrexate (MTX) play an essential role in physiological folate homeostasis and MTX cancer chemotherapy.
M. Hinken +3 more
doaj +5 more sources
The role of folate receptor and reduced folate carrier polymorphisms in osteoporosis development [PDF]
Herba Polonica, 2019 Introduction: Osteoporosis is a chronic metabolic disease with multifactorial etiology. One of possible osteoporosis causes may be impairment of osteoclasts function which leads to increased bone resorption. This may be a result of many metabolic changes.
Mrozikiewicz Aleksandra E. +5 more
doaj +2 more sources
Animal, 2013 Folate transporters, including the reduced folate carrier and the proton-coupled folate transporter, encoded by Slc19a1 and Slc46a1 genes respectively, play important roles in the transport of folate across biological membranes given the hydrophilic ...
M. Jing, G.B. Tactacan, J.D. House
doaj +3 more sources
Methotrexate recognition by the human reduced folate carrier SLC19A1. [PDF]
Nature, 2022 Folates are essential nutrients with important roles as cofactors in one-carbon transfer reactions, being heavily utilized in the synthesis of nucleic acids and the metabolism of amino acids during cell division1,2. Mammals lack de novo folate synthesis pathways and thus rely on folate uptake from the extracellular milieu3.
Wright NJ +8 more
europepmc +3 more sources
Reduced folate carrier 1 (RFC1) is associated with cleft of the lip only [PDF]
Brazilian Journal of Medical and Biological Research, 2008 In this report, we have reanalyzed genotyping data in a collection of families from South America based on maternal origin. Genotyping analysis was performed at the Craniofacial Anomalies Research Center at the University of Iowa.
A.R. Vieira +4 more
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The Reduced Folate Carrier Gene Is a Novel Selectable Marker for Recombinant Protein Overexpression
Molecular Pharmacology, 2005 Folate cofactors are one-carbon donors essential for the biosynthesis of purines and thymidylate. Mammalian cells are devoid of folate biosynthesis and are therefore folate auxotrophs that take up folate vitamins primarily via the reduced folate carrier (RFC).
Rothem, Lilah +4 more
openaire +3 more sources
Development and validation of chemical features-based proton-coupled folate transporter/activity and reduced folate carrier/activity models (pharmacophores). [PDF]
J Mol Graph Model, 2018 All clinically used antifolates lack transport selectivity for tumors over normal cells resulting in dose-limiting toxicities. There is growing interest in developing novel tumor-targeted cytotoxic antifolates with selective transport into tumors over ...
Shah K +4 more
europepmc +2 more sources
Upregulation of reduced folate carrier by vitamin D enhances brain folate uptake in mice lacking folate receptor alpha. [PDF]
Proc Natl Acad Sci U S A, 2019 Significance Folates are critical for brain development and function. Abnormalities in brain folate transport have been implicated in a number of childhood neurodevelopmental disorders, including cerebral folate deficiency syndrome, hereditary folate malabsorption, and autism spectrum disorders.
Alam C +7 more
europepmc +4 more sources
Polymorphisms and Methylation of the Reduced Folate Carrier in Osteosarcoma [PDF]
Clinical Orthopaedics and Related Research, 2008 High-dose methotrexate is a standard component in the treatment of osteogenic sarcoma. Impaired methotrexate uptake associated with decreased reduced folate carrier expression is a common mechanism of methotrexate resistance in osteogenic sarcoma samples.
Rui, Yang +4 more
openaire +2 more sources
Solute carrier transporters, reduced folate carrier 1 and equilibrative nucleoside transporter 1, as immunohistochemical markers for high-grade malignancy in bladder cancer [PDF]
, 2020 Clinicopathological parameters derived from initial transurethral resection of bladder tumor (TUR-Bt) have limitations in predicting tumor progression in bladder cancer.
Tamami, Denda +7 more
core +1 more source