Results 21 to 30 of about 4,058,802 (278)

Novel localization of folate transport systems in the murine central nervous system

Fluids and Barriers of the CNS, 2022
Background Folates are a family of B9 vitamins that serve as one-carbon donors critical to biosynthetic processes required for the development and function of the central nervous system (CNS) in mammals.
Vishal Sangha, Md. Tozammel Hoque, Jeffrey T. Henderson, Reina Bendayan   +3 more
doaj   +1 more source

Interaction between dolutegravir and folate transporters and receptor in human and rodent placenta

EBioMedicine, 2022
Summary: Background: Due to the critical role of folates in neurodevelopment, it is important to understand potential interactions between anti-HIV drugs used during pregnancy, and folate delivery pathways in the placenta.
Julian C. Gilmore, Md. Tozammel Hoque, Wanying Dai, Haneesha Mohan, Caroline Dunk, Lena Serghides, Reina Bendayan   +6 more
doaj   +1 more source

Protective effects of pyrroloquinoline quinone in brain folate deficiency

Fluids and Barriers of the CNS, 2023
Background Folates (Vitamin B9) are critical for normal neurodevelopment and function, with transport mediated by three major pathways: folate receptor alpha (FRα), proton-coupled folate transporter (PCFT), and reduced folate carrier (RFC).
Vishal Sangha, Sara Aboulhassane, Qing Rui Qu, Reina Bendayan   +3 more
doaj   +1 more source

Genetic polymorphisms of vitamin B12 and folate transporter proteins and depression in postpartum period: A case-control study

Journal of Affective Disorders Reports, 2021
Vitamin B12 and folate deficiency have been linked to the susceptibility of developing depression in the postpartum period. Transcobalamin-2 (TCN-2) and reduced folate carrier (RFC-1) are essential for the cellular uptake of vitamin B12 and folate ...
Pooja Dhiman, Raji Ramachandran Pillai, Anand Babu Wilson, Nancy Premkumar, Balaji Bharadwaj, P. Veena, Soundravally Rajendiran   +6 more
doaj   +1 more source

Reduced folate carrier 80A→G polymorphism, plasma folate, and risk of placental abruption [PDF]

Human Genetics, 2008
Folate deficiency and maternal smoking are strong risk factors for placental abruption. We assessed whether the reduced folate carrier [NM_194255.1: c.80A-->G (i.e., p.His27Arg)] (RFC-1) polymorphism was associated with placental abruption, and evaluated if maternal smoking modified the association between plasma folate and abruption. Data were derived
Cande V, Ananth, Morgan R, Peltier, Dirk F, Moore, Wendy L, Kinzler, Daniel, Leclerc, Rima R, Rozen   +5 more
openaire   +2 more sources

Mutations in the reduced-folate carrier affect protein localization and stability [PDF]

Biochemical Journal, 2000
The reduced-folate-carrier (rfc) gene has been shown to be functionally important for reduced-folate transport in mammalian cells. In the present paper we describe the identification of alterations in both alleles of the rfc gene in a mutant Chinese-hamster ovary cell line deficient in methotrexate transport. One allele of the rfc gene contains a point
H, Sadlish, R C, Murray, F M, Williams, W F, Flintoff   +3 more
openaire   +2 more sources

Folate transporter dynamics and therapy with classic and tumor-targeted antifolates

Scientific Reports, 2021
There are three major folate uptake systems in human tissues and tumors, including the reduced folate carrier (RFC), folate receptors (FRs) and proton-coupled folate transporter (PCFT). We studied the functional interrelationships among these systems for
Carrie O’Connor, Adrianne Wallace-Povirk, Changwen Ning, Josephine Frühauf, Nian Tong, Aleem Gangjee, Larry H. Matherly, Zhanjun Hou   +7 more
doaj   +1 more source

Physiological responses to folate overproduction in Lactobacillus plantarum WCFS1 [PDF]

, 2010
Background Using a functional genomics approach we addressed the impact of folate overproduction on metabolite formation and gene expression in Lactobacillus plantarum WCFS1.
Vos, W.M., de, Willem M de Vos, Smid Eddy J, Eddy J Smid, Smid, E.J., Faijes Magda, Vos, R.C.H., de, Mars Astrid E, de Vos, R.C.H.., Klaus, M.J., Molenaar, D., Mars, A.E., Sebastian MJ Klaus, Molenaar, D.; id_orcid, Hanson, A.D., Wegkamp Arno, Douwe Molenaar, Astrid E Mars, Wegkamp, H.B.A., Molenaar Douwe, Klaus, S.M.J., Hanson Andrew D, Wegkamp, A., Magda Faijes, Faijes, M., Vos, W.M., Arno Wegkamp, de Vos Willem M, de Vos Ric CH, Andrew D Hanson, Klaus Sebastian MJ, Ric CH de Vos   +31 more
core   +1 more source

Cytoplasmic domains of the reduced folate carrier are essential for trafficking, but not function [PDF]

Biochemical Journal, 2002
The reduced folate carrier (RFC) protein has a secondary structure consistent with the predicted 12 transmembrane (TM) domains, intracellular N- and C-termini and a large cytoplasmic loop between TM6 and TM7. In the present study, the role of the cytoplasmic domains in substrate transport and protein biogenesis were examined using an array of hamster ...
Heather, Sadlish, Frederick M R, Williams, Wayne F, Flintoff   +2 more
openaire   +2 more sources

Folate catabolites in spot urine as non-invasive biomarkers of folate status during habitual intake and folic acid supplementation. [PDF]

, 2013
Folate status, as reflected by red blood cell (RCF) and plasma folates (PF), is related to health and disease risk. Folate degradation products para-aminobenzoylglutamate (pABG) and para-acetamidobenzoylglutamate (apABG) in 24 hour urine have recently ...
Berthold Koletzko (144194), Rauh-Pfeiffer Astrid, Demmelmair Hans, Astrid Rauh-Pfeiffer, Weith, Thea, Berthold Koletzko, Weith Thea, Marola van Lipzig (282250), Rauh-Pfeiffer, Astrid, Mareile Niesser, Rauh-Pfeiffer, Astrid A. M., Wolfgang Peissner (282252), Niesser Mareile, Vaes Wouter, Peissner Wolfgang, Moretti, Diego, Hans Demmelmair (212025), Demmelmair, Hans, Diego Moretti, Vaes, Wouter, Diego Moretti (282248), Wouter Vaes (282251), van Lipzig Marola, Koletzko Berthold, van Lipzig, Marola, Astrid Rauh-Pfeiffer (282249), Hans Demmelmair, Thea Weith, Wolfgang Peissner, Moretti Diego, Koletzko, Berthold, Marola van Lipzig, Thea Weith (282247), Peissner, Wolfgang, Wouter Vaes, Niesser, Mareile, Mareile Niesser (282246)   +36 more
core   +2 more sources