Results 81 to 90 of about 4,949 (187)

The teneurin C-terminal domain possesses nuclease activity and is apoptogenic. [PDF]

, 2018
Teneurins are type 2 transmembrane proteins expressed by developing neurons during periods of synaptogenesis and apoptosis. Neurons expressing teneurin-1 synapse with other teneurin-1-expressing neurons, and neurons expressing teneurin-2 synapse with ...
Chiquet-Ehrismann, Ruth, Ferralli, Jacqueline, Tucker, Richard P   +2 more
core   +3 more sources

Minimierung des Mutterkornbefalls im Hybridroggen durch Ansätze der Präzisionszüchtung

Journal für Kulturpflanzen, 2009
In Hybridsorten bei Winterroggen führt das Restorergen Rfp1 zu einer vollständigen Restauration der männlichen Fertilität und trägt dazu bei, die Kontamination des Erntegutes mit Mutterkorn zu minimieren.
Bernd Hackauf, Stefan Stojałowski, Heinrich Wortmann, Peer Wilde, Franz Joachim Fromme, Jutta Menzel, Viktor Korzun, Peter Wehling   +7 more
doaj   +1 more source

Evolutionary clues to eukaryotic DNA clamp-loading mechanisms: analysis of the functional constraints imposed on replication factor C AAA+ ATPases [PDF]

, 2005
Ring-shaped sliding clamps encircle DNA and bind to DNA polymerase, thereby preventing it from falling off during DNA replication. In eukaryotes, sliding clamps are loaded onto DNA by the replication factor C (RFC) complex, which consists of five ...
Neuwald, Andrew F.
core   +1 more source

Nationwide Characterization of MFN2‐Related CMT in 176 Japanese Patients: Clinical and Genetic Insights

Annals of Clinical and Translational Neurology, Volume 13, Issue 1, Page 170-179, January 2026.
ABSTRACT Background Mitofusin 2 (MFN2) is a major causative gene for axonal Charcot – Marie – Tooth disease type 2A (CMT2A), with a wide phenotypic spectrum. Comprehensive large ‐ scale genotype – phenotype association studies are essential for understanding disease pathogenesis and improved clinical management.
Masahiro Ando, Yujiro Higuchi, Jun‐Hui Yuan, Akiko Yoshimura, Chikashi Yano, Takahiro Hobara, Fumikazu Kojima, Yu Hiramatsu, Satoshi Nozuma, Tomonori Nakamura, Yusuke Sakiyama, Jun Mitsui, Shoji Tsuji, Hiroshi Takashima   +13 more
wiley   +1 more source

Mass spectrometry in ocular drug research

Mass Spectrometry Reviews, Volume 45, Issue 1, Page 37-68, January/February 2026.
Abstract Mass spectrometry (MS) has been proven as an excellent tool in ocular drug research allowing analyzes from small samples and low concentrations. This review begins with a short introduction to eye physiology and ocular pharmacokinetics and the relevance of advancing ophthalmic treatments.
Eva M. del Amo, Kati‐Sisko Vellonen, Arto Urtti, Tetsuya Terasaki, Anam Hammid, Paavo Honkakoski, Seppo Auriola   +6 more
wiley   +1 more source

Effect of reduced folate carrier gene polymorphism (G80A) on the methotrexate level in patients with rheumatoid arthritis and it’s relation to the disease activity

Science Journal of University of Zakho
Methotrexate (MTX) is the primary conventional synthetic disease-modifying anti-rheumatic drug (csDMARD) used to treat rheumatoid arthritis (RA).
Rozheen Jaafar, Adil Eissa
doaj   +1 more source

Methionine synthase A2756G and reduced folate carrier1 A80G gene polymorphisms as maternal risk factors for Down syndrome in Egypt

Egyptian Journal of Medical Human Genetics, 2016
Background: Polymorphisms of genes encoding enzymes involved in folate metabolism have long been hypothesized to be maternal risk factors for Down syndrome, however, results are conflicting and inconclusive.
Maha Moustafa, Elham Gaber, Gamal Abo El Fath   +2 more
doaj   +1 more source

Application of a Sensitive and Reproducible Label-Free Proteomic Approach to Explore the Proteome of Individual Meiotic-Phase Barley Anthers [PDF]

, 2019
Meiosis is a highly dynamic and precisely regulated process of cell division, leading to the production of haploid gametes from one diploid parental cell.
Alpert, Baerenfaller, Barakate, Bensaddek, Clair, Colas, Collado-Romero, Cox, Cox, Deal, Geiger, Granvogl, Gómez, Hebert, Higgins, Hongay, Hughes, Kamal, Kasuga, Knoll, Lee, Li, Liu, Liu, Marcon, Mascher, Mata, Mercier, Mittmann, Osman, Schwartz, Sheoran, Svozil, Svozil, Szklarczyk, Szymanski, Uváèková, Virant-Klun, Ye, Ye, Zhong   +40 more
core   +6 more sources

Reduced folate carrier 1 (RFC1) gene polymorphisms among acute lymphoblastic leukemia patients

Journal of Biological Research
Reduced Folate Carrier1 (RFC1) gene's metabolism is crucial for DNA synthesis, epigenetic mechanisms, and cellular methylation events. Nonetheless, RFC1 polymorphisms have drawn a lot of interest in current medical genetics studies. The objectives of the
Mashaer Taha Edris, Maye Mohammad Merghani , Shaza Salih Gafar , Ahmed Mohamed Asmeli , Elrashed B. Yasin, Raed Alserihi , Haitham M.H. Qutob , Aymen Yasin, Elshazali Ali   +8 more
doaj   +1 more source

Genetic variation in genes interacting with BRCA1/2 and risk of breast cancer in Cypriot population. [PDF]

, 2010
Inability to correctly repair DNA damage is known to play a role in the development of breast cancer. Single nucleotide polymorphisms (SNPs) of DNA repair genes have been identified, which modify the DNA repair capacity, which in turn may affect the risk
Bashiardes, E, Cariolou, MA, Daniel, M, Hadjisavvas, A, Kakouri, E, Loizidou, MA, Marcou, Y, Michael, T, Neuhausen, SL, Newbold, RF   +9 more
core