Background Two distinct lineages of rhadinoviruses related to Kaposi's sarcoma-associated herpesvirus (KSHV/HHV8) have been identified in macaques and other Old World non-human primates. We have developed a real-time quantitative PCR (QPCR) assay using a
Thouless Margaret E +3 more
doaj +1 more source
Inhibiting KSHV replication by targeting the essential activities of KSHV processivity protein, PF-8. [PDF]
Abstract Kaposi's Sarcoma Herpesvirus (KSHV) is the causative agent of several human diseases. There are no cures for KSHV infection. KSHV establishes biphasic lifelong infections. During the lytic phase, new genomes are replicated by seven viral DNA replication proteins.
Travis JK, Costantini LM.
europepmc +2 more sources
Rhesus Rhadinovirus Establishes a Latent Infection in B Lymphocytes In Vivo [PDF]
ABSTRACT Recent DNA sequence analysis indicates that rhesus rhadinovirus (RRV) is a member of the lymphotropic gamma-2 herpesvirus family. To determine if RRV is lymphotropic, peripheral blood mononuclear cells from naturally infected monkeys were separated by immunomagnetic bead depletion and analyzed for the presence of RRV by ...
E P, Bergquam +4 more
openaire +2 more sources
A review of latency in the Alloherpesviridae family. [PDF]
Abstract The ability to impact the immune response of the host has been recognized as essential for the success of a virus during infection. A few groups of viruses can combine these immunomodulatory mechanisms with specific patterns of their own transcriptional and replication regulation to achieve persistence within the host long term.
Quijano Cardé EM, Soto E.
europepmc +2 more sources
Human Herpesvirus 8--the First Human Rhadinovirus
Kaposi's sarcoma (KS)-associated herpesvirus, also known as human herpesvirus 8 (HHV-8), is the first known human member of the genus Rhadinovirus. It is regularly found by polymerase chain reaction in all forms of KS, in certain types of Castleman's disease, and in body cavity-based B-cell lymphoma.
F, Neipel +2 more
openaire +2 more sources
Disruption of LANA in Rhesus Rhadinovirus Generates a Highly Lytic Recombinant Virus [PDF]
ABSTRACT Rhesus monkey rhadinovirus (RRV) is a gammaherpesvirus that is closely related to human Kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8). RRV is the closest relative to KSHV that has a fully sequenced genome and serves as an in vitro and an in vivo model system for KSHV.
Kwun Wah, Wen +2 more
openaire +2 more sources
Macaque models of human infectious disease. [PDF]
Macaques have served as models for more than 70 human infectious diseases of diverse etiologies, including a multitude of agents-bacteria, viruses, fungi, parasites, prions.
Abe +330 more
core +1 more source
Glycoprotein gene sequence variation in rhesus monkey rhadinovirus
Gene sequences for seven glycoproteins from 20 independent isolates of rhesus monkey rhadinovirus (RRV) and of the corresponding seven glycoprotein genes from nine strains of the Kaposi's sarcoma-associated herpesvirus (KSHV) were obtained and analyzed. Phylogenetic analysis revealed two discrete groupings of RRV gH sequences, two discrete groupings of
Shin, Young C. +6 more
openaire +3 more sources
Complete Genome Sequence of Pig-Tailed Macaque Rhadinovirus 2 and Its Evolutionary Relationship with Rhesus Macaque Rhadinovirus and Human Herpesvirus 8/Kaposi's Sarcoma-Associated Herpesvirus [PDF]
ABSTRACT Two rhadinovirus lineages have been identified in Old World primates. The rhadinovirus 1 (RV1) lineage consists of human herpesvirus 8, Kaposi's sarcoma-associated herpesvirus (KSHV), and closely related rhadinoviruses of chimpanzees, gorillas, macaques and other Old World primates.
A Gregory, Bruce +5 more
openaire +2 more sources
Epstein-Barr virus genetics: talking about the BAC generation [PDF]
Genetic mutant organisms pervade all areas of Biology. Early on, herpesviruses (HV) were found to be amenable to genetic analysis using homologous recombination techniques in eukaryotic cells.
Regina Feederle +2 more
core +1 more source

