An LC-MS Method to Quantify Rhein and Its Metabolites in Plasma: Application to a Pharmacokinetic Study in Rats [PDF]
MetabolitesBackground: Diacerein, a prodrug of Rhein, is commonly prescribed for the management of joint disorders, specifically osteoarthritis. This study aimed to develop and validate an LC-MS/MS method to quantify Rhein and its major metabolites, Rhein-G1 and ...
Nyma Siddiqui +5 more
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Rhein protects against renal aging and fibrotic injury by multiple targets through inhibition of TNF-α-mediated autophagy and necroptosis crosstalk [PDF]
Frontiers in PharmacologyIntroductionRhein, an anthraquinone derived from rhubarb, exhibits renoprotective effects in aging and kidney injury; however, the mechanistic interplay with TNF-α-mediated cell death pathways remains undefined.MethodsUsing D-galactose (D-gal)-treated ...
Yue Tu +11 more
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Rhein alleviates hepatic steatosis in NAFLD mice by activating the AMPK/ACC/SREBP1 pathway to enhance lipid metabolism [PDF]
Molecular MedicineBackground Non-alcoholic fatty liver disease (NAFLD) is a common metabolic liver disorder characterized by excessive lipid accumulation. The 5’-adenosine monophosphate-activated protein kinase (AMPK)/acetyl-CoA carboxylase (ACC)/sterol regulatory element-
Weiwei Dai, Qishu Hou, Jifeng Ye
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Rhein Alleviates Cisplatin-Induced Acute Kidney Injury via Downregulation of NOX4-COX2/PGFS Signaling Pathway [PDF]
Drug Design, Development and TherapyXi Yuan,1,2 Luosha Long,1,2 Minghui Wang,1,2 Wenhao Chen,1,2 Baien Liang,2,3 Long Xu,1,2 Weidong Wang,2,3 Chunling Li1,2 1Department of Physiology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, People’s Republic of China; 2Institute of
Yuan X +7 more
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The Phytochemical Rhein Mediates M6A-Independent Suppression of Adipocyte Differentiation
Frontiers in Nutrition, 2021 Adipogenesis is mediated by the complex gene expression networks involving the posttranscriptional modifications. The natural compound rhein has been linked to the regulation of adipogenesis, but the underlying regulatory mechanisms remain elusive ...
Linyuan Huang +9 more
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Rhein attenuates angiotensin II-induced cardiac remodeling by modulating AMPK–FGF23 signaling
Journal of Translational Medicine, 2022 Background Increasing evidence indicates that myocardial oxidative injury plays a crucial role in the pathophysiology of cardiac hypertrophy (CH) and heart failure (HF).
Wei Lu +5 more
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Preparation of Bioactive De-Chlorophyll Rhein-Rich Senna alata Extract
Antibiotics, 2023 Senna alata leaves display various biological activities as a result of their rhein and phenolic composition. The objective of this study was to develop bioactive de-chlorophyll rhein-rich S. alata extracts.
Wah Wah Aung +8 more
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Rhein for treating diabetes mellitus: A pharmacological and mechanistic overview
Frontiers in Pharmacology, 2023 With the extension of life expectancy and changes in lifestyle, the prevalence of diabetes mellitus is increasing worldwide. Rheum palmatum L. a natural botanical medicine, has been used for thousands of years to prevent and treat diabetes mellitus in ...
Tingting Deng +9 more
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The Effects of the Combination of Rhein and Platelet-Rich Plasma on Human Articular Chondrocytes
Life, 2023 Background: The presence of side effects and low bioavailability of rhein has limited its use in the treatment of osteoarthritis. We aimed to evaluate the in vitro response of human articular chondrocytes to the presence of the combination of platelet ...
Mario Simental-Mendía +6 more
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Virus Research, 2023 African swine fever (ASF) is a virulent infectious diseases of pigs caused by the African swine fever virus (ASFV) that can spread widely and cause high fatality rates.
Zebu Song +8 more
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