Results 11 to 20 of about 125,675 (280)

Fibrin glue delivery system containing rhein ameliorates intervertebral disc degeneration by anti-inflammatory efficacy

Journal of Orthopaedic Surgery and Research, 2023
Purpose To construct an injectable, sustained-release fibrin gel containing rhein to solve the problem of low bioavailability of rhein, and observe its efficacy in the treatment of intervertebral disc degeneration. Methods The fibrin gel containing rhein
Jianhang Bao, Wenshuo Gao, Wei Zhang, Dong Wang, Hao Pan   +4 more
doaj   +1 more source

Anti-proliferative effect of rhein, an anthraquinone isolated from Cassia species, on Caco-2 human adenocarcinoma cells [PDF]

, 2009
Objective: In recent years the use of anthraquinone laxatives, in particular senna, has been associated with damage to the intestinal epithelial layer and an increased risk of developing colorectal cancer.
Bellion, Borrelli, Capasso, Capasso, Chambard, Chen, Cichewicz, Commane, Dhawan, Esterbauer, Fässler, Geboes, Geboes, Gill, Joo, Junttila, Karihtala, Kleibeuker, Kune, Laitinen, Legendre, Lemli, Leng-Peschlow, Leonard, Leone, Lipkin, Loft, Martinez-Palamo, Mascolo, Meloche, Morita, Mosmann, Müller-Lissner, Nakabeppu, Nascimbeni, Nusko, Nusko, Patel, Pearson, Renis, Repetto, Riecken, Roberts, Ronen, Schörkhuber, Siegers, Steer, Van Gorkom, Van Gorkom, Van Gorkom, Villanacci, Viswanathan, Wald, Wargovich, Wu, Yagi, Yokomizo, Zhou   +57 more
core   +1 more source

Rhein ameliorates transverse aortic constriction-induced cardiac hypertrophy via regulating STAT3 and p38 MAPK signaling pathways

Frontiers in Pharmacology, 2022
The progression from compensatory hypertrophy to heart failure is difficult to reverse, in part due to extracellular matrix fibrosis and continuous activation of abnormal signaling pathways. Although the anthraquinone rhein has been examined for its many
Run-Jing Li, Jia-Jia Xu, Zheng-Hao Zhang, Min-Wei Chen, Shi-Xiao Liu, Cui Yang, Yan-Ling Li, Ping Luo, Yi-Jiang Liu, Rong Tang, Zhong-Gui Shan   +10 more
doaj   +1 more source

The effects of rhein on D-GalN/LPS-induced acute liver injury in mice: Results from gut microbiome-metabolomics and host transcriptome analysis

Frontiers in Immunology, 2022
BackgroundRhubarb is an important traditional Chinese medicine, and rhein is one of its most important active ingredients. Studies have found that rhein can improve ulcerative colitis by regulating gut microbes, but there are few reports on its effects ...
Shuhui Liu, Ruiying Yin, Ziwei Yang, Feili Wei, Jianhua Hu   +4 more
doaj   +1 more source

Rhein induces apoptosis of human gastric cancer SGC-7901 cells via an intrinsic mitochondrial pathway

Brazilian Journal of Medical and Biological Research, 2012
Rhein is a primary anthraquinone found in the roots of a traditional Chinese herb, rhubarb, and has been shown to have some anticancer effects. The aim of the present study was to investigate the effect of rhein on the apoptosis of the human gastric ...
Yiwen Li, Yuqing Xu, Bo Lei, Wenxiu Wang, Xin Ge, Jingrui Li   +5 more
doaj   +3 more sources

Rhein Protects Against Severe Acute Pancreatitis In vitro and In vivo by Regulating the JAK2/STAT3 Pathway

Frontiers in Pharmacology, 2022
Rhein is widely used in inflammation treatment in China, but its effects on severe acute pancreatitis (SAP) have not been studied closely. This study investigated rhein’s protective effects against SAP using in vitro and in vivo models to determine ...
Xiaofang Yang, Huan Geng, Lijiao You, Lin Yuan, Jialei Meng, Yuhui Ma, Xuelian Gu, Ming Lei   +7 more
doaj   +1 more source

Proteomic analysis of rhein-induced cyt: ER stress mediates cell death in breast cancer cells [PDF]

, 2015
Rhein is a natural product purified from herbal plants such as Rheum palmatum, which has been shown to have anti-angiogenesis and anti-tumor metastasis properties.
Chan, Hong-Lin, Chen, Yi-Wen, Chou, Hsiu-Chuan, Huang, Hui-Ju, Lin, Chi-Chen, Lin, Dai-Ying, Lin, Szu-Ting, Lin, Yi-Chieh, Lyu, Kevin W   +8 more
core   +1 more source

Anti-influenza A virus activity of rhein through regulating oxidative stress, TLR4, Akt, MAPK, and NF-κB signal pathways. [PDF]

PLoS ONE, 2018
Rhein, an anthraquinone compound existing in many traditional herbal medicines, has anti-inflammatory, antioxidant, antitumor, antiviral, hepatoprotective, and nephroprotective activities, but its anti-influenza A virus (IAV) activity is ambiguous.
Qian-Wen Wang, Yun Su, Jiang-Tao Sheng, Li-Ming Gu, Ying Zhao, Xiao-Xuan Chen, Cheng Chen, Wei-Zhong Li, Kang-Sheng Li, Jian-Ping Dai   +9 more
doaj   +1 more source

Sources, fate, and pathways of Leeuwin Current water in the Indian Ocean and Great Australian Bight: A Lagrangian study in an eddy-resolving ocean model [PDF]

, 2016
The Leeuwin Current is the dominant circulation feature in the eastern Indian Ocean, transporting tropical and subtropical water southward. While it is known that the Leeuwin Current draws its water from a multitude of sources, existing Indian Ocean ...
Barnier B., Madec G., Rhein M.
core   +3 more sources

An integrative in-silico approach for therapeutic target identification in the human pathogen Corynebacterium diphtheriae [PDF]

, 2017
Corynebacterium diphtheriae (Cd) is a Gram-positive human pathogen responsible for diphtheria infection and once regarded for high mortalities worldwide.
Azevedo, Vasco A.C., Barh, Debmalya, Baumbach, Jan, Benevides, Leandro de Jesus, Costa, Daniela Arruda, Ghosh, Preetam, Hassan, Syed Shah, Jamal, Syed Babar, Röttger, Richard, Silva, Artur, Tiwari, Sandeep, Turjanski, Adrián G., Ullah, Asad, Viana, Marcus V.   +13 more
core   +12 more sources