Results 121 to 130 of about 166,738 (337)

Prevalence of hemoglobinopathy, ABO and rhesus blood groups in rural areas of West Bengal, India

Journal of Research in Medical Sciences, 2012
Background: Hemoglobinopathies are a group of inherited disorders of hemoglobin synthesis. It could be formed a fatal scenario in concern of lacking of actual information.
Bikash Mondal, Soumyajit Maiti, Biplab Kumar Biswas, Debidas Ghosh, Shyamapada Paul   +4 more
doaj  

Caloric restriction reduces age-related and all-cause mortality in rhesus monkeys

Nature Communications, 2014
Caloric restriction (CR) without malnutrition increases longevity and delays the onset of age-associated disorders in short-lived species, from unicellular organisms to laboratory mice and rats. The value of CR as a tool to understand human ageing relies
R. Colman, T. Beasley, Joseph W. Kemnitz, S. C. Johnson, R. Weindruch, Rozalyn M. Anderson   +5 more
semanticscholar   +1 more source

Evaluation of dimethandrolone undecanoate in non‐human primates as a candidate for long‐acting injectable male contraceptive

Andrology, EarlyView.
Abstract Background Dimethandrolone undecanoate (DMAU) is under development as a single agent hormonal male contraceptive. DMAU is a prodrug hydrolyzed by esterase(s) to the active metabolite dimethandrolone (DMA) which has dual androgenic and progestogenic actions.
Deborah I. Bunin, Kyuri Kim, Toufan Parman, Janet Gahagen, Mary B. Zelinski, Tiffany Adevai, Christina Wang, Liang Tang, Lalitha Iyer, Aaron Endsley, Diana L. Blithe, Min S. Lee   +11 more
wiley   +1 more source

Durability and correlates of vaccine protection against Zika virus in rhesus monkeys

Science Translational Medicine, 2017
Not all vaccines afford robust protection against ZIKV challenge in rhesus monkeys at 1 year after vaccination. Patience pays off As an individual may not encounter the pathogen for years after they have been vaccinated, efficacious vaccines typically ...
P. Abbink, R. Larocca, Kittipos Visitsunthorn, M. Boyd, Rafael A. De La Barrera, Gregory D. Gromowski, Marinela Kirilova, R. Peterson, Zhenfeng Li, Ovini Nanayakkara, Ramya Nityanandam, N. Mercado, E. Borducchi, A. Chandrashekar, David Jetton, Shanell Mojta, Priya Gandhi, J. LeSuer, Shreeya Khatiwada, M. Lewis, K. Modjarrad, R. Jarman, K. Eckels, Stephen J. Thomas, N. Michael, D. Barouch   +25 more
semanticscholar   +1 more source

Kisspeptin as a test of hypothalamic dysfunction in pubertal and reproductive disorders

Andrology, EarlyView.
Abstract The hypothalamic–pituitary–gonadal axis is regulated by the gonadotropin‐releasing hormone pulse generator in the hypothalamus. This is comprised of neurons that secrete kisspeptin in a pulsatile manner to stimulate the release of GnRH, and, in turn, downstream gonadotropins from the pituitary gland, and subsequently sex steroids and ...
Aureliane C. S. Pierret, Aaran H. Patel, Elisabeth Daniels, Alexander N. Comninos, Waljit S. Dhillo, Ali Abbara   +5 more
wiley   +1 more source

Hematological and biochemical parameters for Chinese rhesus macaque.

PLoS ONE, 2019
Rhesus macaque is an important animal model in biomedical research, especially human disease, developmental, translational, and pre-clinical research.
Wenhai Yu, Xianhui Hao, Fengmei Yang, Jin Ma, Yuan Zhao, Yanyan Li, Junbin Wang, Hongjie Xu, Lixiong Chen, Quan Liu, Suqin Duan, Yaping Yang, Fen Huang, Zhanlong He   +13 more
doaj   +1 more source

SELECTIVE DESTRUCTION OF LARGE MOTONEURONS BY POLIOMYEITIS VIRUS II. SIZE OF MOTONEURONS IN THE SPINAL CORD OF RHESUS MONKEYS [PDF]

, 1949
Robert Hodes, SAMUEL. M. PEACOCK, DAVID BODLAN   +2 more
openalex   +1 more source

Protective efficacy of adenovirus/protein vaccines against SIV challenges in rhesus monkeys

Science, 2015
To defeat SIV, add a protein boost Despite 30 years of effort, no HIV-1 vaccine exists. Barouch et al. evaluated one promising strategy in rhesus macaques, a preclinical model commonly used to test potential HIV-1 vaccine candidates.
D. Barouch, G. Alter, Thomas A. Broge, C. Linde, M. Ackerman, E. Brown, E. Borducchi, Kaitlin M. Smith, Joseph P. Nkolola, Jinyan Liu, Jennifer L. Shields, Lily Parenteau, J. Whitney, P. Abbink, D. Ng'ang'a, M. Seaman, C. Lavine, J. Perry, Wenjun Li, Arnaud D. Colantonio, M. Lewis, Bing Chen, H. Wenschuh, U. Reimer, M. Piatak, J. Lifson, S. Handley, H. Virgin, M. Koutsoukos, C. Lorin, G. Voss, M. Weijtens, M. Pau, H. Schuitemaker   +33 more
semanticscholar   +1 more source

Role for the liver X receptor agonist 22‐ketositosterol in preventing disease progression in an Alzheimer's disease mouse model

British Journal of Pharmacology, EarlyView.
Background and Purpose Liver X receptors (LXRs) are promising therapeutic targets for alleviating Alzheimer's disease (AD) symptoms. We assessed the impact of the semi‐synthetic LXR agonist 22‐ketositosterol on disease progression in an AD mouse model.
Nikita Martens, Na Zhan, Sammie C. Yam, Marcella Palumbo, Lorenzo Pontini, Frank P. J. Leijten, Leonie van Vark‐van der Zee, Gardi Voortman, Silvia Friedrichs, Albert Gerding, Maura Marinozzi, Johan W. Jonker, Folkert Kuipers, Dieter Lütjohann, Tim Vanmierlo, Monique T. Mulder   +15 more
wiley   +1 more source

Organoid Models to Study Human Infectious Diseases

Cell Proliferation, EarlyView.
Our manuscript reviews the role of organoids as models for studying human infectious diseases, highlighting their irreplaceable contributions to drug testing and vaccine development for significant infectious diseases including HIV, ZIKV, SARS‐CoV‐2 and MPXV.
Sijing Zhu, Dan Chen, Xinzhi Yang, Liuliu Yang, Yuling Han   +4 more
wiley   +1 more source