Results 61 to 70 of about 65,503 (295)

Potent and Long‐Lasting Immunogenicity Generated by LNP‐mRNA gE Antigen Against Varicella Zoster Virus via an AI‐Assisted Pipeline

Advanced Science, EarlyView.
This study designs a novel mRNA‐LNP vaccine targeting VZV glycoprotein E (gE) for herpes zoster via an AI‐assisted pipeline. Validated in mice and rhesus macaques, the mRNA‐LNP vaccine shows strong humoral and cellular immune responses, with CD4+ T‐cell responses more effective and durable than Shingrix, offering a promising prophylactic option ...
Kai Dong, Fang Liu, Dawei Wang, Yanfen Li, Man Zhang, Yuting Zhou, Gengshen Song   +6 more
wiley   +1 more source

A Microbiota‐ and IL‐15‐Dependent Innate‐Like B Cell Progenitor Expressing E4BP4

Advanced Science, EarlyView.
This work identifies CD3.NKp46.CD19.NK1.1. NK‐B cells enriched in PDK1‐deficient yet present in wild‐type bone marrow. IL‐15 (via CD122) and TLR9‐microbiota signaling maintain their E4BP4 expression. These cells demonstrate innate immunity, preferentially differentiate into B cells, and unveil a novel microbiota‐ and IL‐15‐dependent regulatory pathway ...
Junming He, Xinlei Hou, Xiaomei Feng, Yayun Dong, Mengqi Ren, Surong Deng, Xinru Yang, Donglin Chen, Lingna Zhao, Shasha Chen, Meixiang Yang, Zhongjun Dong   +11 more
wiley   +1 more source

Long-read structural variant discovery and targeted short read genotyping enables population scale characterization of structural variation in rhesus macaques

Genome Biology
Background Due to their close evolutionary relationship with humans, rhesus macaques are an important pre-clinical model. While genetic diversity driven by short nucleotide variation has long been studied in rhesus macaques, there is comparatively little
Karina Ray, Christina Mulch, Samuel M. Peterson, Sebastian Benjamin, Nathan Gullicksrud, Adam J. Ericsen, Eric J. Vallender, Betsy M. Ferguson, Jeffrey D. Wall, Benjamin N. Bimber   +9 more
doaj   +1 more source

Sex-specific heritability of spontaneous lipid levels in an extended pedigree of Indian-origin rhesus macaques (Macaca mulatta). [PDF]

PLoS ONE, 2013
The rhesus macaque is an important model for human atherosclerosis but genetic determinants of relevant phenotypes have not yet been investigated in this species.
Amanda Vinson, Asia D Mitchell, David Toffey, Jacob Silver, Michael J Raboin   +4 more
doaj   +1 more source

Ebola Virus Localization in the Macaque Reproductive Tract during Acute Ebola Virus Disease. [PDF]

, 2018
Sexual transmission of Ebola virus (EBOV) has been demonstrated more than a year after recovery from the acute phase of Ebola virus disease (EVD). The mechanisms underlying EBOV persistence and sexual transmission are not currently understood.
Bernbaum, John G., Hagen, Katie R., Holbrook, Michael R., Huzella, Louis M., Jahrling, Peter B., Johnson, Reed F., Perry, Donna L., Schnell, Matthias J.   +7 more
core   +1 more source

The statistical neuroanatomy of frontal networks in the macaque [PDF]

, 2008
We were interested in gaining insight into the functional properties of frontal networks based upon their anatomical inputs. We took a neuroinformatics approach, carrying out maximum likelihood hierarchical cluster analysis on 25 frontal cortical areas ...
A Bechara, A Papoulis, AD Craig, AF Arnsten, AN McCoy, AWF Edwards, B De Martino, BB Averbeck, BB Averbeck, Bruno B. Averbeck, C Padoa-Schioppa, CC Hilgetag, CI Hooker, D Ongur, DJ Felleman, EA Thompson, ET Rolls, G Aston-Jones, G Rainer, H Barbas, H Barbas, H Niki, HT Ghashghaei, J Felsenstein, J Felsenstein, J Lauwereyns, J O'Doherty, J Parvizi, J Vezoli, JD Wallis, JI Gold, JN Kim, K Hikosaka, K Matsumoto, K Nakamura, Karl J. Friston, KE Stephan, LM Romanski, LM Romanski, M Koenigs, M Shidara, MC Dorris, MJ Webster, ML Kringelbach, MM Botvinick, MM Mesulam, Moonsang Seo, MP Young, MR Roesch, NL Rempel-Clower, PH Rudebeck, R Kötter, RE Passingham, RP Dum, S Ito, S Kobayashi, SC Rao, ST Carmichael, SW Kennerley, T Ikeda, T Margush, W Fries, WG Frankle, WJ Nauta, Y Pawitan   +64 more
core   +4 more sources

Diffusion‐MRI‐Based Estimation of Cortical Architecture via Machine Learning (DECAM) in Primate Brains

Advanced Science, EarlyView.
We present Diffusion‐MRI‐based Estimation of Cortical Architecture via Machine Learning (DECAM), a deep‐learning framework for estimating primate brain cortical architecture optimized with best response constraint and cortical label vectors. Trained using macaque brain high‐resolution multi‐shell dMRI and histology data, DECAM generates high‐fidelity ...
Tianjia Zhu, Minhui Ouyang, Shufang Tan, Jianlin Guo, Ziqin Zhang, Xuan Liu, Risheng Liu, Hao Huang   +7 more
wiley   +1 more source

Intercenter reliability and validity of the rhesus macaque GeneChip

BMC Genomics, 2007
Background The non-human primate (NHP) research community has been intensely interested in obtaining whole-genome expression arrays for their work. Recently, novel approaches were used to generate the DNA sequence information for a rhesus GeneChip.
Duan Fenghai, Spindel Eliot R, Li Yu-Hua, Norgren Robert B   +3 more
doaj   +1 more source

Malaria disrupts the rhesus macaque gut microbiome

Frontiers in Cellular and Infection Microbiology, 2023
Previous studies have suggested that a relationship exists between severity and transmissibility of malaria and variations in the gut microbiome, yet only limited information exists on the temporal dynamics of the gut microbial community during a malarial infection.
Danielle N. Farinella, Sukhpreet Kaur, ViLinh Tran, Monica Cabrera-Mora, Monica Cabrera-Mora, Chester J. Joyner, Chester J. Joyner, Stacey A. Lapp, Stacey A. Lapp, Suman B. Pakala, Mustafa V. Nural, Jeremy D. DeBarry, Jeremy D. DeBarry, Jeremy D. DeBarry, Jessica C. Kissinger, Jessica C. Kissinger, Jessica C. Kissinger, Dean P. Jones, Alberto Moreno, Alberto Moreno, Alberto Moreno, Mary R. Galinski, Mary R. Galinski, Mary R. Galinski, Regina Joice Cordy, Regina Joice Cordy   +25 more
openaire   +3 more sources

Convergent and Divergent Connectivity Patterns of the Arcuate Fasciculus in Macaques and Humans

Advanced Science, EarlyView.
This study employs viral‐based single‐neuron tracing and dMRI‐based whole‐brain tractography to investigate arcuate fasciculus (AF) trajectories in macaque monkeys, and compares with the human AF connectome using spectral embedding. Results demonstrate conserved AF topography spanning temporoparietal‐auditory‐frontal pathways across primates, with ...
Jiahao Huang, Ruifeng Li, Wenwen Yu, Anan Li, Xiangning Li, Mingchao Yan, Lei Xie, Qingrun Zeng, Xueyan Jia, Shuxin Wang, Ronghui Ju, Feng Chen, Qingming Luo, Hui Gong, Andrew Zalesky, Xiaoquan Yang, Yuanjing Feng, Zheng Wang   +17 more
wiley   +1 more source