Results 11 to 20 of about 53,223 (176)

The role of IL-15 deficiency in the pathogenesis of virus-induced asthma exacerbations.

PLoS Pathogens, 2011
Rhinovirus infections are the major cause of asthma exacerbations. We hypothesised that IL-15, a cytokine implicated in innate and acquired antiviral immunity, may be deficient in asthma and important in the pathogenesis of asthma exacerbations.
Vasile Laza-Stanca, Simon D Message, Michael R Edwards, Hayley L Parker, Mihnea T Zdrenghea, Tatiana Kebadze, Onn M Kon, Patrick Mallia, Luminita A Stanciu, Sebastian L Johnston   +9 more
doaj   +1 more source

Rhinovirus induces airway remodeling: what are the physiological consequences?

Respiratory Research, 2023
Background Rhinovirus infections commonly evoke asthma exacerbations in children and adults. Recurrent asthma exacerbations are associated with injury-repair responses in the airways that collectively contribute to airway remodeling.
Cassandra Spector, Camden M. De Sanctis, Reynold A. Panettieri, Cynthia J. Koziol-White   +3 more
doaj   +1 more source

Prevalence of rhinovirus in wheezing children: a comparison with respiratory syncytial virus wheezing

Brazilian Journal of Infectious Diseases, 2016
Objective: To explore the distribution and clinical manifestations of rhinovirus infection in wheezing children, and compare the clinical differences between rhinovirus- and respiratory syncytial virus-induced wheezing.
Huiquan Sun, Qiufeng Sun, Wunjun Jiang, Zhengrong Chen, Li Huang, Meijuan Wang, Wei Ji, Xuejun Shao, Yongdong Yan   +8 more
doaj   +1 more source

Rhinovirus and airway allergy

Allergology International, 2004
Rhinoviruses cause the majority of common colds, which often provoke wheezing in patients with asthma. The precise mechanisms responsible for the rhinovirus infection-induced exacerbations of bronchial asthma remain uncertain.
Mutsuo Yamaya, Hidetada Sasaki
doaj   +1 more source

Interference between rhinovirus and influenza A virus: a clinical data analysis and experimental infection study

The Lancet Microbe, 2020
Summary: Background: During the 2009 pandemic of an emerging influenza A virus (IAV; H1N1pdm09), data from several European countries indicated that the spread of the virus might have been interrupted by the annual autumn rhinovirus epidemic.
Anchi Wu, BSE, Valia T Mihaylova, PhD, Marie L Landry, ProfMD, Ellen F Foxman, ProfMD   +3 more
doaj   +1 more source

Rhinovirus-induced basic fibroblast growth factor release mediates airway remodeling features

Clinical and Translational Allergy, 2012
Background Human rhinoviruses, major precipitants of asthma exacerbations, induce lower airway inflammation and mediate angiogenesis. The purpose of this study was to assess the possibility that rhinoviruses may also contribute to the fibrotic component ...
Skevaki Chrysanthi L, Psarras Stelios, Volonaki Eleni, Pratsinis Harris, Spyridaki Irini S, Gaga Mina, Georgiou Vassiliki, Vittorakis Stylianos, Telcian Aurica G, Maggina Paraskevi, Kletsas Dimitris, Gourgiotis Dimitrios, Johnston Sebastian L, Papadopoulos Nikolaos G   +13 more
doaj   +1 more source

Co-ordinated role of TLR3, RIG-I and MDA5 in the innate response to rhinovirus in bronchial epithelium.

PLoS Pathogens, 2010
The relative roles of the endosomal TLR3/7/8 versus the intracellular RNA helicases RIG-I and MDA5 in viral infection is much debated. We investigated the roles of each pattern recognition receptor in rhinovirus infection using primary bronchial ...
Louise Slater, Nathan W Bartlett, Jennifer J Haas, Jie Zhu, Simon D Message, Ross P Walton, Annemarie Sykes, Samer Dahdaleh, Deborah L Clarke, Maria G Belvisi, Onn M Kon, Takashi Fujita, Peter K Jeffery, Sebastian L Johnston, Michael R Edwards   +14 more
doaj   +1 more source

Rhinovirus-induced epithelial RIG-I inflammasome suppresses antiviral immunity and promotes inflammation in asthma and COVID-19

Nature Communications, 2023
Rhinoviruses and allergens, such as house dust mite are major agents responsible for asthma exacerbations. The influence of pre-existing airway inflammation on the infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is largely ...
Urszula Radzikowska, Andrzej Eljaszewicz, Ge Tan, Nino Stocker, Anja Heider, Patrick Westermann, Silvio Steiner, Anita Dreher, Paulina Wawrzyniak, Beate Rückert, Juan Rodriguez-Coira, Damir Zhakparov, Mengting Huang, Bogdan Jakiela, Marek Sanak, Marcin Moniuszko, Liam O’Mahony, Marek Jutel, Tatiana Kebadze, David J. Jackson, Michael R. Edwards, Volker Thiel, Sebastian L. Johnston, Cezmi A. Akdis, Milena Sokolowska   +24 more
doaj   +1 more source

Human rhinovirus detection in the lower respiratory tract of hematopoietic cell transplant recipients: association with mortality

Haematologica, 2017
Human rhinoviruses are the most common respiratory viruses detected in patients after hematopoietic cell transplantation. Although rhinovirus appears to occasionally cause severe lower respiratory tract infection in immunocompromised patients, the ...
Sachiko Seo, Alpana Waghmare, Emily M Scott, Hu Xie, Jane M Kuypers, Robert C. Hackman, Angela P. Campbell, Su-Mi Choi, Wendy M. Leisenring, Keith R. Jerome, Janet A. Englund, Michael Boeckh   +11 more
doaj   +1 more source

Additional Rhinovirus Serotypes

Experimental Biology and Medicine, 1964
SummaryFifty-two rhinovirus strains were isolated from 672 cases of acute respiratory illness in children and adults and 4 strains were recovered from well controls. Respiratory disease cases among adults which yielded a rhinovirus were nearly all upper respiratory illness (common cold) whereas the cases among children often showed lower respiratory ...
V V, HAMPARIAN, M B, LEAGUS, M R, HILLEMAN   +2 more
openaire   +2 more sources