Results 71 to 80 of about 31,404 (177)
British Journal of Pharmacology, EarlyView.Background and Purpose Myeloid‐derived suppressor cells (MDSCs) play important roles in the pathogenesis of asthma. Recent studies demonstrate that their function can be modulated by different pharmacological approaches. In this study, we focussed on the effects of systemically administered prostaglandin EP4 receptor agonist L‐902,688 and pegylated ...
Tim Lange +7 more
wiley +1 more source
Mechanism of human rhinovirus infections [PDF]
Molecular and Cellular Pediatrics, 2016 About 150 human rhinovirus serotypes are responsible for more than 50 % of recurrent upper respiratory infections. Despite having similar 3D structures, some bind members of the low-density lipoprotein receptor family, some ICAM-1, and some use CDHR3 for host cell infection. This is also reflected in the pathways exploited for cellular entry.
Renate Fuchs, Dieter Blaas
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Brazilian Journal of Infectious Diseases, 2016 Objective: To explore the distribution and clinical manifestations of rhinovirus infection in wheezing children, and compare the clinical differences between rhinovirus- and respiratory syncytial virus-induced wheezing.
Huiquan Sun +8 more
doaj
Frontiers in Immunology, 2020 Human rhinoviruses (HRV) are the most common cause of viral respiratory tract infections. While normally mild and self-limiting in healthy adults, HRV infections are associated with bronchiolitis in infants, pneumonia in immunocompromised patients, and ...
Víctor Casanova +9 more
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Early Origins of Asthma and Allergies: Clues From Studies in China
Clinical &Experimental Allergy, EarlyView.The environment we live in harbours both risk and protective factors for asthma and allergies. This is particularly relevant in China, where unique environmental and cultural factors shape disease development. The interplay between these environmental factors, airway immunity, and gut microbiome shapes the susceptibility to asthma and allergies ...
Yike Wang +5 more
wiley +1 more source
Respiratory admissions and impact of COVID‐19 lockdowns for children with severe cerebral palsy
Developmental Medicine &Child Neurology, EarlyView.In a population cohort of children with severe cerebral palsy, there was a reduced frequency of hospitalization for respiratory illness during periods of restricted social contact, implemented to reduce transmission of COVID‐19. This mirrored trends in the wider population and underlines the importance of community viral transmission in these children.
Susan M. Reid +9 more
wiley +1 more source
Rhinovirus inhibition by bufadienolides.
Chemical and Pharmaceutical Bulletin, 1988 An evaluation of thirty-four bufadienolides and two related cardenolides against a series of rhinoviruses in vitro has been completed. Most of the bufadienolides were found to display some inhibitory activity. Scillarenin and 3-O-[N-(tert-butoxycarbonyl)hydrazido]succinylbufalin were found to be the most active with chemotherapeutic indices of 32 and ...
Cecil R. Smith +4 more
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Introduction: emerging importance of the rhinovirus [PDF]
The American Journal of Medicine, 2002 Acute viral respiratory infections (VRIs) encompass a range of illnesses that together constitute the most frequent infections of humans. The most prevalent syndrome is that characterized by signs and symptoms of the common cold, or acute viral rhinosinusitis.
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Lethal Respiratory Disease Associated with Human Rhinovirus C in Wild Chimpanzees, Uganda, 2013
Emerging Infectious Diseases, 2018 We describe a lethal respiratory outbreak among wild chimpanzees in Uganda in 2013 for which molecular and epidemiologic analyses implicate human rhinovirus C as the cause.
Erik J. Scully +13 more
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Frontiers in Microbiology, 2020 Thermal shift assays measure the stability of macromolecules and macromolecular assemblies as a function of temperature. The Particle Stability Thermal Release Assay (PaSTRy) of picornaviruses is based on probes becoming strongly fluorescent upon binding
Antonio Real-Hohn +4 more
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