Results 1 to 10 of about 105,843 (252)

Rho Kinase in Eye Disease [PDF]

Journal of Ophthalmology, 2017
Naoki Okumura, Shintaro Nakao, Toshihiro Inoue, Padmanabhan Pattabiraman   +3 more
doaj   +3 more sources

Morphometric Analysis of Rat Prostate Development: Roles of MEK/ERK and Rho Signaling Pathways in Prostatic Morphogenesis

Biomolecules, 2021
The molecular mechanisms underlying prostate development can provide clues for prostate cancer research. It has been demonstrated that MEK/ERK signaling downstream of androgen-targeted FGF10 signaling directly induces prostatic branching during ...
Wen-Yang Hu, Parivash Afradiasbagharani, Ranli Lu, Lifeng Liu, Lynn A. Birch, Gail S. Prins   +5 more
doaj   +1 more source

Peptide substrates for Rho-associated kinase 2 (Rho-kinase 2/ROCK2). [PDF]

PLoS ONE, 2011
Peptide substrates sensitive for a certain protein kinase could be important for new-drug development and to understand the mechanism of diseases. Rho-associated kinase (Rho-kinase/ROCK) is a serine/threonine kinase, and plays an important part in ...
Jeong-Hun Kang, Daisuke Asai, Akira Tsuchiya, Takeshi Mori, Takuro Niidome, Yoshiki Katayama   +5 more
doaj   +1 more source

Identification of the Kinase-Substrate Recognition Interface between MYPT1 and Rho-Kinase

Biomolecules, 2022
Protein kinases exert physiological functions through phosphorylating their specific substrates; however, the mode of kinase–substrate recognition is not fully understood.
Mutsuki Amano, Yoko Kanazawa, Kei Kozawa, Kozo Kaibuchi   +3 more
doaj   +1 more source

Rho-kinase inhibition ameliorates metabolic disorders through activation of AMPK pathway in mice. [PDF]

PLoS ONE, 2014
BACKGROUND: Metabolic disorders, caused by excessive calorie intake and low physical activity, are important cardiovascular risk factors. Rho-kinase, an effector protein of the small GTP-binding protein RhoA, is an important cardiovascular therapeutic ...
Kazuki Noda, Sota Nakajima, Shigeo Godo, Hiroki Saito, Shohei Ikeda, Toru Shimizu, Budbazar Enkhjargal, Yoshihiro Fukumoto, Sohei Tsukita, Tetsuya Yamada, Hideki Katagiri, Hiroaki Shimokawa   +11 more
doaj   +1 more source

Inhibition of Rho-kinase improves response to deep inspiration in ovalbumin-sensitized guinea pigs [PDF]

Iranian Journal of Basic Medical Sciences, 2020
Objective(s): The modulatory effect of deep inspiration (DI) on airway constriction is impaired in asthma. However, mechanisms underlying this impairment are not clear.
Saeed Pazhoohan, Ehsan Aref, Leila Zare, Samaneh Dehghan, Mohammad Javan, Sohrab Hajizadeh, Mohammad Reza Rauofy   +6 more
doaj   +1 more source

Rho-kinase inhibitors in ophthalmology

TNOA Journal of Ophthalmic Science and Research, 2021
Rho-kinase (ROCK) inhibitor is the newer drug available for glaucoma in the Indian market. It seems to target the actual area of disease pathology which has not been the case with the available medications. With the ever-evolving potential of these drugs
Megha Gopalakrishna, Srinivasan Kavitha
doaj   +1 more source

Rho-kinase activation in leukocytes plays a pivotal role in myocardial ischemia/reperfusion injury. [PDF]

PLoS ONE, 2014
The Rho/Rho-kinase pathway plays an important role in many cardiovascular diseases such as hypertension, atherosclerosis, heart failure, and myocardial infarction.
Katsunori Kitano, Soichiro Usui, Hiroshi Ootsuji, Shin-ichiro Takashima, Daisuke Kobayashi, Hisayoshi Murai, Hiroshi Furusho, Ayano Nomura, Shuichi Kaneko, Masayuki Takamura   +9 more
doaj   +1 more source

Molecular Mechanisms and Therapeutic Strategies of Chronic Renal Injury: Renoprotective Effect of Rho-Kinase Inhibitor in Hypertensive Glomerulosclerosis

Journal of Pharmacological Sciences, 2006
.: Among the GTP-binding proteins, Rho is known to function as a molecular switch in various cellular functions. Among the Rho effectors, the cellular function and signal transduction of Rho-kinase have been extensively studied.
Toshio Nishikimi, Hiroaki Matsuoka
doaj   +1 more source

Impaired Corpus Cavernosum Relaxation Is Accompanied by Increased Oxidative Stress and Up-Regulation of the Rho-Kinase Pathway in Diabetic (Db/Db) Mice. [PDF]

PLoS ONE, 2016
Basal release of nitric oxide from endothelial cells modulates contractile activity in the corpus cavernosum via inhibition of the RhoA/Rho-kinase signaling pathway.
Fernanda B M Priviero, Haroldo A F Toque, Kenia Pedrosa Nunes, Denise G Priolli, Cleber E Teixeira, R Clinton Webb   +5 more
doaj   +1 more source