Results 21 to 30 of about 105,843 (252)

Mechanical stress regulates gene expression via Rho/Rho-kinase signaling pathway

Journal of Physical Fitness and Sports Medicine, 2015
Exercise improves the performance of the cardiovascular system, striated muscle, and bones, and reduces obesity. Exercise provides for mechanical forces, which include fluid flow and stretching.
Takako Kaneko-Kawano, Kenji Suzuki
doaj   +1 more source

Inhibition of RhoA/Rho kinase signaling pathway by fasudil protects against kainic acid‐induced neurite injury

Brain and Behavior, 2021
Aim RhoA/Rho kinase pathway is essential for regulating cytoskeletal structure. Although its effect on normal neurite outgrowth has been demonstrated, the role of this pathway in seizure‐induced neurite injury has not been revealed. The research examined
Yingchun Xiang, Yumiao Niu, Yacong Xie, Shishuo Chen, Feng Zhu, Weida Shen, Ling‐Hui Zeng   +6 more
doaj   +1 more source

Molecular Mechanisms and Therapeutic Strategies of Chronic Renal Injury: Role of Rho-Kinase in the Development of Renal Injury

Journal of Pharmacological Sciences, 2006
.: Rho/Rho-kinase plays an important role not only in the vasoconstrictor mechanism but also in cellular morphology, motility, adhesion, and proliferation.
Koichi Hayashi, Shu Wakino, Takeshi Kanda, Koichiro Homma, Naoki Sugano, Takao Saruta   +5 more
doaj   +1 more source

Rho-kinase inhibitors

Folia Pharmacologica Japonica, 2011
Rhoキナーゼは1995～1996年に，低分子量GTP結合タンパク質Rhoの標的タンパク質として同定されたセリン・スレオニンタンパク質リン酸化酵素である．これまでの研究により，Rhoキナーゼは収縮，増殖，遊走，遺伝子発現誘導など細胞の重要な生理機能に関与していることが明らかになっている．また各種病態動物モデルを使用した解析より，Rhoキナーゼの活性亢進が数々の病態を引き起こす原因となっていることが示され，創薬のターゲットとして注目されている．RhoキナーゼにはROCK1とROCK2の2つのアイソフォームがあり高い相同性を有している．ROCK1とROCK2は体内に広く発現しているがROCK2は特に脳と骨格筋に強く発現している．現在製薬メーカーを中心に精力的にRhoキナーゼ阻害薬の開発が行われている ...
Seto, Minoru, Asano, Toshio
openaire   +3 more sources

Combination therapy with atorvastatin and amlodipine suppresses angiotensin II-induced aortic aneurysm formation. [PDF]

PLoS ONE, 2013
BACKGROUND: Abdominal aortic aneurysm (AAA) is a life-threatening vascular disease. It is controversial whether statin and calcium channel blockers (CCBs) has an inhibitory effect on the expansion of AAA.
Kikuyo Takahashi, Yasuharu Matsumoto, Zhulanqiqige Do e, Masanori Kanazawa, Kimio Satoh, Takuya Shimizu, Akira Sato, Yoshihiro Fukumoto, Hiroaki Shimokawa   +8 more
doaj   +1 more source

Effects of chronic Δ9-tetrahydrocannabinol treatment on Rho/Rho-kinase signalization pathway in mouse brain

Saudi Pharmaceutical Journal, 2017
Δ9-Tetrahydrocannabinol (Δ9-THC) shows its effects by activating cannabinoid receptors which are on some tissues and neurons. Cannabinoid systems have role on cell proliferation and development of neurons.
Halil Mahir Kaplan, Percin Pazarci
doaj   +1 more source

The Rho/Rho-kinase Systems Are Involved in Rapid Pacing-induced Changes of Atrial Refractory Period in a Canine Model

Journal of Arrhythmia, 2006
Introduction: The Rho/Rho-kinase pathway has been related to various physiological responses of the cardiovascular system. Previous reports have suggested a significant effect of Rho signals on the electrophysiological characteristics of the heart.
Hiroshi Furusho, MD, Satoru Sakagami, MD PHD, Masayuki Takamura, MD PHD, Katsunori Kitano, MD, Tsuyoshi Abe, MD, Motoaki Hirazawa, MD, Soichiro Usui, MD PHD, Masaki Okajima, MD PHD, Takahiro Saeki, MD PHD, Michiro Maruyama, MD PHD, Shuichi Kaneko, MD PHD, Sigeo Takata, MD PHD   +11 more
doaj   +1 more source

Angiotensin II-Induced Vasoconstriction via Rho Kinase Activation in Pressure-Overloaded Rat Thoracic Aortas

Biomolecules, 2021
Angiotensin II (Ang II) induces vasoconstriction through myosin light chain (MLC) kinase activation and MLC phosphatase inactivation via phosphorylation of myosin phosphatase targeting subunit 1 (MYPT1) by Rho kinase.
Yuka Terada, Katsutoshi Yayama
doaj   +1 more source

IL‐31 levels correlate with pruritus in patients with cholestatic and metabolic liver diseases and is farnesoid X receptor responsive in NASH

Hepatology, EarlyView., 2022
IL‐31 levels correlate with pruritus in patients with cholestatic and metabolic liver diseases Abstract Background and Aims Pruritus is associated with multiple liver diseases, particularly those with cholestasis, but the mechanism remains incompletely understood.
Jun Xu, Ya Wang, Mina Khoshdeli, Matt Peach, Jen‐Chieh Chuang, Julie Lin, Wen‐Wei Tsai, Sangeetha Mahadevan, Wesley Minto, Lauri Diehl, Ruchi Gupta, Michael Trauner, Keyur Patel, Mazen Noureddin, Kris V. Kowdley, Aliya Gulamhusein, Christopher L. Bowlus, Ryan S. Huss, Robert P. Myers, Chuhan Chung, Andrew N. Billin   +20 more
wiley   +1 more source

Thrombopoietin and collagen in low doses cooperatively induce human platelet activation

Acute Medicine & Surgery, 2022
Aim In acute medicine, we occasionally treat life‐threatening conditions such as sepsis and trauma, which cause severe thrombocytopenia. Serum thrombopoietin levels have been reported to increase under the condition of thrombocytopenia related to ...
Tomoaki Doi, Takamitsu Hori, Takashi Onuma, Daisuke Mizutani, Kyohei Ueda, Yukiko Enomoto, Rie Matsushima‐Nishiwaki, Kumiko Tanabe, Tomoyuki Hioki, Haruhiko Tokuda, Toru Iwama, Hiroki Iida, Osamu Kozawa, Shinji Ogura   +13 more
doaj   +1 more source