Results 11 to 20 of about 105,843 (252)

Effect of alpha-linolenic acid on aminoglycoside nephrotoxicity and RhoA/Rho-kinase pathway in kidney [PDF]

PeerJ
Aminoglycoside nephrotoxicity stands as a primary contributor to the development of acute intrinsic renal failure. Distinctive characteristic associated with this nephrotoxicity is the occurrence of tubular necrosis, which is why it is commonly referred ...
Percin Pazarci, Serkan Özler, Halil Mahir Kaplan   +2 more
doaj   +3 more sources

Inhibition of Rho‐kinase restores impaired relaxation of airway smooth muscle in rat pups exposed to neonatal hyperoxia [PDF]

Physiological Reports
Neonatal hyperoxia is a key contributor to bronchopulmonary dysplasia (BPD) which is characterized by airway hyperreactivity due to increased contraction and impaired relaxation of airway smooth muscle (ASM). This study investigated whether inhibition of
Ramadan B. Sopi, Qëndrim Thaçi, Thomas M. Raffay, Qëndresa Beqiraj‐Zeqiraj   +3 more
doaj   +2 more sources

Cigarette Smoke Exposure Leads to Organic and Mineral Bone Component Changes: The Importance of Rho Kinase Function in These Events [PDF]

Cells
Aberrant Rho-associated kinase function could be associated with increased bone fragility. Since cigarette smoke (CS) exposure promotes the increase in bone fragility due to changes in bone tissue components, this study aimed to investigate how CS ...
Alex Ferreira da Silva, Franciele Jesus Lima, Alyne Riani Moreira, Cintia do Nascimento Silva, Ivone Braga de Oliveira, Alexandra Fernandes Callera, Ana Luiza Porfirio, Luan Henrique Vasconcelos Alves, Iolanda de Fátima Lopes Calvo Tibério, Ana Paula Pereira Velosa, Vanda Jorgetti, Walcy Rosolia Teodoro, Fernanda Degobbi Tibério Quirino Dos Santos Lopes   +12 more
doaj   +2 more sources

Distinct Effects of Nonselective Rho‐Kinase Inhibitor Fasudil and Selective Rho‐Kinase 2 Inhibitor KD025 on Serotonin and Dopamine Release in the Nucleus Accumbens of Mice [PDF]

Neuropsychopharmacology Reports
Recent studies have indicated that the Rho GTPase family and Rho‐kinases are associated with psychiatric diseases, such as schizophrenia. Two subtypes of Rho‐kinase, Rho‐kinases 1 and 2, regulate actin dynamics and mediate neurite outgrowth, spine ...
Rinako Tanaka, Wenjun Zhu, Taku Nagai, Toshitaka Nabeshima, Kozo Kaibuchi, Norio Ozaki, Hiroaki Ikesue, Hiroyuki Mizoguchi, Kiyofumi Yamada   +8 more
doaj   +2 more sources

A Protective Effect of Pirfenidone in Lung Fibroblast–Endothelial Cell Network via Inhibition of Rho-Kinase Activity [PDF]

Biomedicines, 2023
Pulmonary fibrosis is a life-threatening disease that has been attributed to several causes. Specifically, vascular injury is thought to be involved in the pathogenesis of fibrosis.
Yusuke Nakamura, Yasuo Shimizu, Mio Fujimaki-Shiraishi, Nobuhiko Uchida, Akihiro Takemasa, Seiji Niho   +5 more
doaj   +2 more sources

Rho-kinase inhibition reduces subretinal fibrosis [PDF]

Cell Death Discovery
Subretinal fibrosis, a consequence of choroidal neovascularization (CNV) in age-related macular degeneration (AMD), leads to irreversible vision loss due to excessive accumulation of extracellular matrix (ECM) proteins and fibrotic scarring.
Yuebing Li, Tural Yarahmadov, Laura Jahnke, Tess Brodie, Sophia C. Morandi, Deborah Stroka, Ali Hafezi-Moghadam, Martin S. Zinkernagel, Volker Enzmann, Souska Zandi   +9 more
doaj   +2 more sources

Paxillin participates in the sphingosylphosphorylcholine-induced abnormal contraction of vascular smooth muscle by regulating Rho-kinase activation [PDF]

Cell Communication and Signaling
Background The Ca2+-independent contraction of vascular smooth muscle is a leading cause of cardiovascular and cerebrovascular spasms. In the previous study, we demonstrated the involvement of Src family protein tyrosine kinase Fyn and Rho-kinase in the ...
Ying Zhang, Nan Li, Sei Kobayashi
doaj   +2 more sources

The COOH Terminus of Rho-kinase Negatively Regulates Rho-kinase Activity [PDF]

Journal of Biological Chemistry, 1999
Rho-kinase is implicated in the phosphorylation of myosin light chain downstream of Rho, which is thought to induce smooth muscle contraction and stress fiber formation in non-muscle cells. Here, we examined the mode of action of inhibitors of Rho-kinase.
M, Amano, K, Chihara, N, Nakamura, T, Kaneko, Y, Matsuura, K, Kaibuchi   +5 more
openaire   +2 more sources

Rho kinase inhibitors ameliorate cognitive impairment in a male mouse model of methamphetamine-induced schizophrenia

Pharmacological Research, 2023
Schizophrenia (SCZ) is a severe psychiatric disorder characterized by positive symptoms, negative symptoms, and cognitive deficits. Current antipsychotic treatment in SCZ improves positive symptoms but has major side effects and little impact on negative
Jingzhu Liao, Geyao Dong, Wenjun Zhu, Bolati Wulaer, Hiroyuki Mizoguchi, Masahito Sawahata, Yue Liu, Kozo Kaibuchi, Norio Ozaki, Toshitaka Nabeshima, Taku Nagai, Kiyofumi Yamada   +11 more
doaj   +1 more source

Rho Kinase (ROCK) Inhibitors [PDF]

Journal of Cardiovascular Pharmacology, 2007
The Rho kinase (ROCK) isoforms, ROCK1 and ROCK2, were initially discovered as downstream targets of the small GTP-binding protein Rho. Because ROCKs mediate various important cellular functions such as cell shape, motility, secretion, proliferation, and gene expression, it is likely that this pathway will intersect with other signaling pathways known ...
James K, Liao, Minoru, Seto, Kensuke, Noma   +2 more
openaire   +2 more sources