Results 211 to 220 of about 105,843 (252)

Rho-kinase inhibitors in the management of glaucoma

Expert Opinion on Therapeutic Patents, 2019
Introduction: Glaucoma is a group of progressive optic neuropathies in which elevated intraocular pressure (IOP) as a consequence of an increased aqueous humor (AH) outflow resistance, is the main and only clinically modifiable risk factor for its development and progression.
Berrino, Emanuela, Supuran, Claudiu T
openaire   +3 more sources

2,3-Diaminopyrazines as rho kinase inhibitors

Bioorganic & Medicinal Chemistry Letters, 2010
Inhibition of rho kinase (ROCK) has been recognized as an important target for a number of diseases, including glaucoma. Herein we report SAR development around two hits from a kinase library that led to the discovery of the ROCK inhibitor compound 38.
Alan J, Henderson, Mark, Hadden, Cheng, Guo, Neema, Douglas, Helene, Decornez, Mark R, Hellberg, Andrew, Rusinko, Marsha, McLaughlin, Naj, Sharif, Colene, Drace, Raj, Patil   +10 more
openaire   +2 more sources

Regulation of autophagosome formation by Rho kinase

Cellular Signalling, 2013
Macroautophagy, commonly referred to as autophagy, is a protein degradation pathway that functions at a constitutive level in cells, which may become further activated by stressors such as nutrient starvation or protein aggregation. Autophagy has multiple beneficial roles for maintaining normal cellular homeostasis and these roles are related to the ...
Mleczak, Andrzej, Millar, Sarah, Tooze, Sharon A, Olson, Michael F, Chan, Edmond Y W   +4 more
openaire   +4 more sources

Rho-kinase expression in Hirschsprung’s disease

Pediatric Surgery International, 2015
Rho-kinase (ROCK) is the primary effector protein in the RhoA pathway, which regulates Ca(2+)-independent smooth muscle contraction in the human bowel. This pathway has been reported to be hyper-activated in the aganglionic bowel of EDNRB-null (-/-) rats compared to the ganglionic bowel from EDNRB (+/+) rats.
David Coyle, Anne Marie O’Donnell, Nicolae Corcionivoschi, John Gillick, Prem Puri   +4 more
openaire   +2 more sources

Rho kinase inhibitors

2012
COOK BRIAN NICHOLAS, KOWALSKI JENNIFER A, LI XIANG, MARSHALL DANIEL RICHARD, SCHLYER SABINE, SIBLEY ROBERT, SMITH-KEENAN LANA LOUISE, SOLEYMANZADEH FARIBA, SORCEK RONALD JOHN, YOUNG ERICK RICHARD ROUSH, ZHANG YUNLONG   +10 more
  +12 more sources

Effect of the Rho-Kinase/ROCK Signaling Pathway on Cytoskeleton Components

Genes, 2023
Guangzhao Guan, Richard D Cannon, Dawn Coates   +2 more
exaly  

Rho‐kinase inhibition is beneficial in fibrosis

Hepatology, 2017
Görtzen, Jan, Trebicka, Jonel
openaire   +2 more sources

Rho-Kinase Is an Important Therapeutic Target in Cardiovascular Medicine

Arteriosclerosis, Thrombosis, and Vascular Biology, 2005

exaly  

Regulation and Functions of Rho-Associated Kinase

Experimental Cell Research, 2000
Yuko Fukata, Mutsuki Amano, Kozo Kaibuchi   +2 more
exaly  

Rho‐kinase/ROCK: A key regulator of the cytoskeleton and cell polarity

Cytoskeleton, 2010
Mutsuki Amano, Kozo Kaibuchi
exaly