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Rho kinase inhibitor Y-27632 downregulates IL-1β expression in mice with experimental autoimmune myocarditis. [PDF]

open access: yesSci Rep
Li Y   +10 more
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Rho-kinase

Trends in Pharmacological Sciences, 2006
Urinary incontinence and other urinary storage symptoms are frequent in the general population but available treatments have limited efficacy and tolerability. Rho kinase (ROCK) has a central role in the regulation of smooth muscle contraction, including that of the urinary bladder.
Peters, Stephan L. M.   +2 more
  +6 more sources

Rho-Kinase Inhibitors

2013
Pulmonary arterial hypertension (PAH) is a fatal disease with poor prognosis characterized by progressive elevation of pulmonary arterial pressure and vascular resistance due to pulmonary artery hyperconstriction and remodeling; however, the precise mechanism of PAH still remains to be elucidated.
Yoshihiro, Fukumoto, Hiroaki, Shimokawa
openaire   +4 more sources

Rho kinase inhibitors

European Journal of Pharmacology, 2008
In asthma, inflammatory mediators that are released in the airways by recruited inflammatory cells and by resident structural cells result in airway hyperresponsiveness caused by increased bronchoconstriction. In addition, chronic inflammation appears to drive remodelling of the airways that contributes to the development of fixed airway obstruction ...
BOSANAC TODD   +11 more
  +12 more sources

Rho-kinase and effects of Rho-kinase inhibition on the lower urinary tract

Neurourology and Urodynamics, 2007
Altered smooth muscle cell contractility/tone contributes, at least in part, to the lower urinary tract symptoms (LUTS) seen in men with benign prostatic obstruction (BPO). Accordingly, many of the therapies to date have focused largely on blockade of individual membrane receptors to diminish smooth muscle contractility and provide symptomatic relief ...
George J, Christ, Karl-Erik, Andersson
openaire   +2 more sources

Rho Kinases in Autoimmune Diseases

Annual Review of Medicine, 2016
The Rho kinases, or ROCKs, are a family of serine-threonine kinases that serve as key downstream effectors for Rho GTPases. The ROCKs are increasingly recognized as critical coordinators of a tissue response to injury due to their ability to modulate a wide range of biological processes.
Alessandra B, Pernis   +4 more
openaire   +2 more sources

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