Results 191 to 200 of about 105,843 (252)

An Integrated Proteomics and Genomics Approach to Identify Essential Protein Kinases During Human Trophoblast Development

The FASEB Journal, Volume 40, Issue 17, 15 September 2026.
Integrated quantitative proteomic, phosphoproteomic, and transcriptomic analyses of human trophoblast stem cells identify stage‐specific kinase signaling networks that regulate trophoblast self‐renewal and differentiation into syncytiotrophoblasts and extravillous trophoblasts.
Rajnish Kumar, Purbasa Dasgupta, Soma Ray, Soumen Paul   +3 more
wiley   +1 more source

Differential expression of TKS4 isoforms and their role in cellular processes in breast cancer

Journal of Cell Communication and Signaling, Volume 20, Issue 3, September 2026.
TKS4 isoforms are differentially expressed across human cell lines. TKS4L interacts with six novel SRC homology 3‐containing proteins, whereas no interactions were detected for TKS4b. SRC‐mediated phosphorylation promotes interactions of TKS4 with SH2 domains.
Serhii Kropyvko, Nazar Shevchuk, Olga Gubar, Kyrylo Lavrynenko, Yaroslav Nemesh, Denys Kozakov, Valentyn Polishchuk, Valentyna Kryklyva, Liubov Syvak, Nataliia Verovkina, Tetyana Gryaznova   +10 more
wiley   +1 more source

Sildenafil improves hemodynamic changes caused by acute pulmonary embolism by inhibiting Rho kinase activity. [PDF]

J Int Med Res
Wang H, Li W, Yan Y, Shi MJ, Hou F, Zhang RP.   +5 more
europepmc   +1 more source

Rho-kinase pathway.

Circulation journal : official journal of the Japanese Circulation Society, 2013
Koichi, Kaikita, Hisao, Ogawa
openaire   +1 more source

Broadening horizons: Pathogenesis and therapeutics of renal ciliopathies

Journal of Cell Communication and Signaling, Volume 20, Issue 3, September 2026.
This review elucidates the molecular mechanisms and aberrant signaling pathways in renal ciliopathies, links genetic heterogeneity to clinical phenotypes, and lays a theoretical basis for prenatal diagnosis and novel therapies. Abstract Renal ciliopathies encompass a spectrum of genetic disorders arising from structural or functional impairments of ...
Qiaowei Zhang, Shuwen Xue, Zhi Gao, Panlai Shi, Li Wang, Qi Feng, Xiangdong Kong, Xiaofan Zhu   +7 more
wiley   +1 more source

Isoform-selective and non-selective rho-kinase inhibitors do not affect collagenase-induced intracerebral hemorrhage outcomes in mice: Influence of sex and circadian cycle. [PDF]

J Cereb Blood Flow Metab
Imai T, Morais A, Qin T, Sasaki Y, Erdogan T, McKerracher L, Ayata C.   +6 more
europepmc   +1 more source

Exercise‐specific plasma proteomic signatures in racehorses: Candidates for training adaptation and peak load monitoring

Equine Veterinary Journal, Volume 58, Issue 5, Page 1396-1412, September 2026.
Abstract Background Racehorses undergo profound physiological changes with training and competition, but current biomarkers inadequately capture the complex molecular dynamics of exercise. This study aimed to identify novel plasma biomarkers of training adaptation and peak load using high‐throughput proteomics.
Jowita Grzędzicka, Bianka Świderska, Ewa Sitkiewicz, Izabela Dąbrowska, Olga Witkowska‐Piłaszewicz   +4 more
wiley   +1 more source

Enhanced Migration of Fuchs Corneal Endothelial Cells by Rho Kinase Inhibition: A Novel Ex Vivo Descemet's Stripping Only Model. [PDF]

Cells
Parekh M, Miall A, Chou A, Buhl L, Deshpande N, Price MO, Price FW, Jurkunas UV.   +7 more
europepmc   +1 more source

Transcriptomic signatures reveal systemic adaptations and immune modulation in response to training and competitive racing in horses

Equine Veterinary Journal, Volume 58, Issue 5, Page 1413-1444, September 2026.
Abstract Background The molecular mechanisms underlying adaptation to physical exertion and racing stress in horses remain incompletely understood. Peripheral blood transcriptomics offers a minimally invasive method to monitor systemic responses to exercise and identify biomarkers of adaptation or overload. Objectives To evaluate transcriptomic changes
Izabela Dąbrowska, Jowita Grzędzicka‐Agko, Paula Kiełbik, Michał Trela, Olga Witkowska‐Piłaszewicz   +4 more
wiley   +1 more source

Methylation and phosphorylation of formin homology domain proteins (Fhod1 and Fhod3) by protein arginine methyltransferase 7 (PRMT7) and Rho kinase (ROCK1). [PDF]

J Biol Chem
Lowe TL, Valencia DA, Velasquez VE, Quinlan ME, Clarke SG.   +4 more
europepmc   +1 more source