Results 51 to 60 of about 381,524 (309)
Novel role of Ras-GTPase Activating Protein SH3 Domain-Binding Protein G3BP in adhesion and migration of 32D myeloid progenitor cells [PDF]
, 2012 Rho GTPases are involved in homing and mobilization of hematopoietic stem and progenitor cells due to their impact on cytoskeleton remodeling. We have previously shown that inhibition of Rho, Rac and Cdc42 clearly impairs adhesion of normal and leukemic ...
Schwarz, Kerstin +8 more
core +1 more source
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
Dissertation Nursing, 2023 BACKGROUND: Il maltrattamento della persona anziana è un fenomeno sottostimato, rappresenta una violazione dei diritti umani e un grave problema di salute globale che espone le vittime a pesanti conseguenze per la salute.
Stefania Tinti +8 more
doaj +1 more source
Avaliação, in vivo e in vitro, da reatividade vascular renal à vasopressina em ratos endotoxêmicos: importância da via Rho-A/Rho-quinase [PDF]
, 2012 Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas. Programa de Pós-Graduação em FarmacologiaSepse é uma infecção local, acompanhada de uma resposta inflamatória sistêmica e vinculada à elevada incidência e ...
Guarido, Karla Lorena
core
Activation of Rac-1 and RhoA contributes to podocyte injury in chronic kidney disease [PDF]
, 2013 Rho-family GTPases like RhoA and Rac-1 are potent regulators of cellular signaling that control gene expression, migration and inflammation. Activation of Rho-GTPases has been linked to podocyte dysfunction, a feature of chronic kidney diseases (CKD). We
Liliana Schäfer +42 more
core +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
First clinical experiences with a novel endoscopic over-the-scope clip system
Endoscopy International Open, 2017 We describe our experience with a new over-the-scope clip (OTSC) system (Padlock Clip™) in the treatment of 14 patients. Eight of the 14 patients were treated for closure of gastrointestinal fistulas (n = 4), iatrogenic gastrointestinal perforations (n =
Marco Dinelli +5 more
doaj +1 more source
Rho GTPases in Glioblastoma Mechanobiology [PDF]
, 2020 Brain tumors are a source of morbidity and mortality worldwide, especially in children and young adults. Due to the high rates of inherently disabling effects (such as personality changes, visual disturbances, and poor coordination), many patients with ...
Xu, Jing
core
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
The Role of Rho/Rho-Kinase Pathway in the Pathophysiology of Absence Epilepsy
, 2019 Objectives: Rho/Rho-kinase (ROCK) signaling has been shown to contribute to neuroinflammation, epileptogenesis, and seizures in convulsive-type epilepsy models.
Carcak, Nihan +13 more
core +1 more source