Results 1 to 10 of about 44,129 (257)

Role of Rho-associated kinases and their inhibitor fasudil in neurodegenerative diseases [PDF]

Frontiers in Neuroscience
Neurodegenerative diseases (NDDs) are prevalent in the elderly. The pathogenesis of NDDs is complex, and currently, there is no cure available. With the increase in aging population, over 20 million people are affected by common NDDs alone (Alzheimer’s ...
Qiuyan Ye, Xue Li, Wei Gao, Wei Gao, Jiayue Gao, Liping Zheng, Miaomiao Zhang, Fengge Yang, Honglin Li, Honglin Li   +9 more
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Advantages of Rho-associated kinases and their inhibitor fasudil for the treatment of neurodegenerative diseases [PDF]

Neural Regeneration Research, 2022
Ras homolog (Rho)-associated kinases (ROCKs) belong to the serine-threonine kinase family, which plays a pivotal role in regulating the damage, survival, axon guidance, and regeneration of neurons.
Qing Wang, Li-Juan Song, Zhi-Bin Ding, Zhi Chai, Jie-Zhong Yu, Bao-Guo Xiao, Cun-Gen Ma   +6 more
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Statins change the cytokine profile in Trypanosoma cruzi-infected U937 macrophages and murine cardiac tissue through Rho-associated kinases inhibition [PDF]

Frontiers in Immunology, 2023
IntroductionChronic Chagasic cardiomyopathy (CCC), caused by the protozoan Trypanosoma cruzi, is the most severe manifestation of Chagas disease.CCC is characterized by cardiac inflammation and fibrosis caused by a persistent inflammatory response ...
Fabiola González-Herrera, Natasha S. Clayton, Daniela Guzmán-Rivera, Ileana Carrillo, Christian Castillo, Mabel Catalán, Renatto Anfossi, Helena Quintero-Pertuz, María Elena Quilaqueo, Claudio Olea-Azar, Mario Rivera-Meza, Ulrike Kemmerling, Anne J. Ridley, Raúl Vivar, Juan Diego Maya   +14 more
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Inhibition of Rho-associated kinases disturbs the collective cell migration of stratified TE-10 cells [PDF]

Biological Research, 2015
BACKGROUND: The collective cell migration of stratified epithelial cells is considered to be an important phenomenon in wound healing, development, and cancer invasion; however, little is known about the mechanisms involved.
Taro Mikami, Keiichiro Yoshida, Hajime Sawada, Michiyo Esaki, Kazunori Yasumura, Michio Ono   +5 more
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Rho-Associated Kinases and Non-muscle Myosin IIs Inhibit the Differentiation of Human iPSCs to Pancreatic Endoderm [PDF]

Stem Cell Reports, 2017
Summary: There has been increasing success with the generation of pancreatic cells from human induced pluripotent stem cells (hiPSCs); however, the molecular mechanisms of the differentiation remain elusive.
Taro Toyoda, Azuma Kimura, Hiromi Tanaka, Tomonaga Ameku, Atsushi Mima, Yurie Hirose, Masahiro Nakamura, Akira Watanabe, Kenji Osafune   +8 more
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Distinct Effects of Nonselective Rho‐Kinase Inhibitor Fasudil and Selective Rho‐Kinase 2 Inhibitor KD025 on Serotonin and Dopamine Release in the Nucleus Accumbens of Mice [PDF]

Neuropsychopharmacology Reports
Recent studies have indicated that the Rho GTPase family and Rho‐kinases are associated with psychiatric diseases, such as schizophrenia. Two subtypes of Rho‐kinase, Rho‐kinases 1 and 2, regulate actin dynamics and mediate neurite outgrowth, spine ...
Rinako Tanaka, Wenjun Zhu, Taku Nagai, Toshitaka Nabeshima, Kozo Kaibuchi, Norio Ozaki, Hiroaki Ikesue, Hiroyuki Mizoguchi, Kiyofumi Yamada   +8 more
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Conditional deficiency of Rho‐associated kinases disrupts endothelial cell junctions and impairs respiratory function in adult mice [PDF]

FEBS Open Bio
The Ras homology (Rho) family of GTPases serves various functions, including promotion of cell migration, adhesion, and transcription, through activation of effector molecule targets.
Takahiro Akamine, Takeshi Terabayashi, Takako Sasaki, Riku Hayashi, Ichitaro Abe, Fumihiro Hirayama, Shin‐ichi Nureki, Masahito Ikawa, Haruhiko Miyata, Akinori Tokunaga, Takashi Kobayashi, Katsuhiro Hanada, Dean Thumkeo, Shuh Narumiya, Toshimasa Ishizaki   +14 more
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The function of Rho-dependent kinases ROCK1 and ROCK2 in the pathogenesis of cardiovascular disease [PDF]

Frontiers in Pharmacology, 2015
Rho-associated kinases ROCK1 and ROCK2 are serine/threonine kinases that are downstream targets of the small GTPases RhoA, RhoB, and RhoC. ROCKs are involved in diverse cellular activities including actin cytoskeleton organization, cell adhesion and ...
Svenja eHartmann, Svenja eHartmann, Anne J. Ridley, Susanne eLutz   +3 more
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Rho-Kinase Inhibitors for the Treatment of Refractory Diabetic Macular Oedema

Cells, 2021
Diabetic macular oedema (DMO) is one of the leading causes of vision loss associated with diabetic retinopathy (DR). New insights in managing this condition have changed the paradigm in its treatment, with intravitreal injections of antivascular ...
Milagros Mateos-Olivares, Luis García-Onrubia, Fco. Javier Valentín-Bravo, Rogelio González-Sarmiento, Maribel Lopez-Galvez, J. Carlos Pastor, Ricardo Usategui-Martín, Salvador Pastor-Idoate   +7 more
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Targeting Rho GTPase Signaling Networks in Cancer

Frontiers in Cell and Developmental Biology, 2020
As key regulators of cytoskeletal dynamics, Rho GTPases coordinate a wide range of cellular processes, including cell polarity, cell migration, and cell cycle progression.
Natasha S. Clayton, Anne J. Ridley
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