Results 11 to 20 of about 44,129 (257)
Targeting Rho associated kinases in leukemia and myeloproliferative neoplasms. [PDF]
Oncotarget, 2012 If ROCKs are going to be targeted as anti-leukemic agents either as a monotherapy or in combination with existing drugs, a better characterization of the relative contribution of ROCK1 and ROCK2 in disease progression is essential.
Mali RS, Kapur R.
europepmc +4 more sources
Rho-associated kinase is a therapeutic target in neuroblastoma [PDF]
Proceedings of the National Academy of Sciences, 2017 Significance Despite intensive therapy, the cure rate for children diagnosed with high-risk neuroblastoma is still below 50%, accentuating the need for more effective therapies. Recurrent somatic mutations are relatively infrequent in neuroblastoma. We show that approximately 30% of neuroblastoma contains mutations in genes regulating
Cecilia Dyberg +12 more
openaire +4 more sources
Phosphorylation and Activation of Myosin by Rho-associated Kinase (Rho-kinase) [PDF]
Journal of Biological Chemistry, 1996 The small GTPase Rho is implicated in physiological functions associated with actin-myosin filaments such as cytokinesis, cell motility, and smooth muscle contraction. We have recently identified and molecularly cloned Rho-associated serine/threonine kinase (Rho-kinase), which is activated by GTP Rho (Matsui, T., Amano, M., Yamamoto, T., Chihara, K ...
M, Amano +7 more
openaire +2 more sources
Abl Kinases Regulate HGF/Met Signaling Required for Epithelial Cell Scattering, Tubulogenesis and Motility. [PDF]
PLoS ONE, 2015 Tight regulation of receptor tyrosine kinases (RTKs) is crucial for normal development and homeostasis. Dysregulation of RTKs signaling is associated with diverse pathological conditions including cancer. The Met RTK is the receptor for hepatocyte growth
Ran Li +3 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2021 The rho-associated coiled-coil-containing proteins (ROCKs or rho kinase) are effectors of the small rho-GTPase rhoA, which acts as a signaling molecule to regulate a variety of cellular processes, including cell proliferation, adhesion, polarity ...
Islam M. Saadeldin +4 more
doaj +1 more source
Microbiology Spectrum, 2022 Nematode-trapping (NT) fungi can form unique infection structures (traps) to capture and kill free-living nematodes and, thus, can play a potential role in the biocontrol of nematodes. Arthrobotrys oligospora is a representative species of NT fungi. Here,
Le Yang +5 more
doaj +1 more source
Dynamic changes in neurexins' alternative splicing: role of Rho-associated protein kinases and relevance to memory formation. [PDF]
PLoS ONE, 2011 The three neurexins genes (NRXN1/2/3) encode polymorphic synaptic membrane proteins that are involved in cognitive functioning. Neurexins' selectivity of function is presumably conferred through differential use of 2 promoters and 5 alternative splicing ...
Gabriela Rozic +3 more
doaj +1 more source
Frontiers in Immunology, 2022 The enteric glial cells (EGCs) participate in the homeostasis of the gastrointestinal tract, and RhoA/ROCK signaling pathway plays a vital role in colonic tight junctions. Hydrogen sulfide (H2S) has been reported to alleviate colitis. However, the effect
Song Wang, Yanyu Ding, Wenjun Jiang
doaj +1 more source
Cells, 2023 Cytoskeleton organization and dynamics are rapidly regulated by post-translational modifications of key target proteins. Acting downstream of the Cdc42 GTPase, the myotonic dystrophy-related Cdc42-binding kinases MRCKα, MRCKβ, and MRCKγ have recently ...
Vanessa M. Ruscetta +6 more
doaj +1 more source
Modulation of statin-activated shedding of Alzheimer APP ectodomain by ROCK.
PLoS Medicine, 2005 BackgroundStatins are widely used cholesterol-lowering drugs that act by inhibiting HMGCoA reductase, the rate-limiting enzyme in cholesterol biosynthesis.
Steve Pedrini +5 more
doaj +1 more source