Results 21 to 30 of about 44,129 (257)

Keratinocyte migration in the developing eyelid requires LIMK2. [PDF]

PLoS ONE, 2012
In vitro studies have identified LIMK2 as a key downstream effector of Rho GTPase-induced changes in cytoskeletal organization. LIMK2 is phosphorylated and activated by Rho associated coiled-coil kinases (ROCKs) in response to a variety of growth factors.
Dennis S Rice, Gwenn M Hansen, Feng Liu, Mike J Crist, Matthew M Newhouse, David Potter, Nianhua Xu, Alejandro Abuin, Peter J Vogel, Brian P Zambrowicz   +9 more
doaj   +1 more source

KANPHOS: A Database of Kinase-Associated Neural Protein Phosphorylation in the Brain

Cells, 2021
Protein phosphorylation plays critical roles in a variety of intracellular signaling pathways and physiological functions that are controlled by neurotransmitters and neuromodulators in the brain.
Rijwan Uddin Ahammad, Tomoki Nishioka, Junichiro Yoshimoto, Takayuki Kannon, Mutsuki Amano, Yasuhiro Funahashi, Daisuke Tsuboi, Md. Omar Faruk, Yukie Yamahashi, Kiyofumi Yamada, Taku Nagai, Kozo Kaibuchi   +11 more
doaj   +1 more source

ROCK Inhibition as Potential Target for Treatment of Pulmonary Hypertension

Cells, 2021
Pulmonary hypertension (PH) is a cardiovascular disease caused by extensive vascular remodeling in the lungs, which ultimately leads to death in consequence of right ventricle (RV) failure.
Tadeu L. Montagnoli, Jaqueline S. da Silva, Susumu Z. Sudo, Aimeé D. Santos, Gabriel F. Gomide, Mauro P. L. de Sá, Gisele Zapata-Sudo   +6 more
doaj   +1 more source

Roles of Rho‑associated kinase in lung cancer (Review)

International Journal of Oncology, 2020
Lung cancer is one of the most lethal forms of cancer known to man, affecting millions of individuals worldwide. Despite advancements being made in lung cancer treatments, the prognosis of patients with the disease remains poor, particularly among patients with late‑stage lung cancer. The elucidation of the signaling pathways involved in lung cancer is
Zakaria, Muhammad Asyaari, Rajab, Nor Fadilah, Eng, Wee Chua, Selvarajah, Gayathri Thevi, Masre, Siti Fathiah   +4 more
openaire   +3 more sources

Rho-associated Kinase of Chicken Gizzard Smooth Muscle [PDF]

Journal of Biological Chemistry, 1999
Rho-associated kinase (Rho-kinase) from chicken gizzard smooth muscle was purified to apparent homogeneity (160 kDa on SDS-polyacrylamide gel electrophoresis) and identified as the ROKalpha isoform. Several substrates were phosphorylated. Rates with myosin phosphatase target subunit 1 (MYPT1), myosin, and the 20-kDa myosin light chain were higher than ...
J, Feng, M, Ito, Y, Kureishi, K, Ichikawa, M, Amano, N, Isaka, K, Okawa, A, Iwamatsu, K, Kaibuchi, D J, Hartshorne, T, Nakano   +10 more
openaire   +2 more sources

A novel Rho-dependent pathway that drives interaction of fascin-1 with p-Lin-11/Isl-1/Mec-3 kinase (LIMK) 1/2 to promote fascin-1/actin binding and filopodia stability

BMC Biology, 2012
Background Fascin-1 is an actin crosslinking protein that is important for the assembly of cell protrusions in neurons, skeletal and smooth muscle, fibroblasts, and dendritic cells.
Jayo Asier, Parsons Maddy, Adams Josephine C   +2 more
doaj   +1 more source

Rho-Associated Kinase Activity Is a Predictor of Cardiovascular Outcomes [PDF]

Hypertension, 2014
Cardiovascular diseases are associated with chronic activation of Rho-associated kinase. Rho-associated kinase activity is significantly correlated with endothelial function and Framingham risk score. However, there is no information on the prognostic value of Rho-associated kinase activity.
Masato, Kajikawa, Kensuke, Noma, Tatsuya, Maruhashi, Shinsuke, Mikami, Yumiko, Iwamoto, Akimichi, Iwamoto, Takeshi, Matsumoto, Takayuki, Hidaka, Yasuki, Kihara, Kazuaki, Chayama, Ayumu, Nakashima, Chikara, Goto, James K, Liao, Yukihito, Higashi   +13 more
openaire   +2 more sources

Roles of Rho-associated Kinase in Cytokinesis; Mutations in Rho-associated Kinase Phosphorylation Sites Impair Cytokinetic Segregation of Glial Filaments [PDF]

The Journal of Cell Biology, 1998
Rho-associated kinase (Rho-kinase), which is activated by the small GTPase Rho, regulates formation of stress fibers and focal adhesions, myosin fiber organization, and neurite retraction through the phosphorylation of cytoskeletal proteins, including myosin light chain, the ERM family proteins (ezrin, radixin, and moesin) and adducin.
Y, Yasui, M, Amano, K, Nagata, N, Inagaki, H, Nakamura, H, Saya, K, Kaibuchi, M, Inagaki   +7 more
openaire   +2 more sources

IL‐31 levels correlate with pruritus in patients with cholestatic and metabolic liver diseases and is farnesoid X receptor responsive in NASH

Hepatology, EarlyView., 2022
IL‐31 levels correlate with pruritus in patients with cholestatic and metabolic liver diseases Abstract Background and Aims Pruritus is associated with multiple liver diseases, particularly those with cholestasis, but the mechanism remains incompletely understood.
Jun Xu, Ya Wang, Mina Khoshdeli, Matt Peach, Jen‐Chieh Chuang, Julie Lin, Wen‐Wei Tsai, Sangeetha Mahadevan, Wesley Minto, Lauri Diehl, Ruchi Gupta, Michael Trauner, Keyur Patel, Mazen Noureddin, Kris V. Kowdley, Aliya Gulamhusein, Christopher L. Bowlus, Ryan S. Huss, Robert P. Myers, Chuhan Chung, Andrew N. Billin   +20 more
wiley   +1 more source

Proteogenomic characterization of cholangiocarcinoma

Hepatology, EarlyView., 2022
Proteogenomic characterization of cholangiocarcinoma with therapeutic strategies Abstract Background and Aims Cholangiocarcinoma (CCA) is a highly heterogeneous cancer with limited understanding and few effective therapeutic approaches. We aimed at providing a proteogenomic CCA characterization to inform biological processes and treatment ...
Mengjie Deng, Peng Ran, Lingli Chen, Yunzhi Wang, Zixiang Yu, Ke Cai, Jinwen Feng, Zhaoyu Qin, Yanan Yin, Subei Tan, Yang Liu, Chen Xu, Guoming Shi, Yuan Ji, Jian‐Yuan Zhao, Jian Zhou, Jia Fan, Yingyong Hou, Chen Ding   +18 more
wiley   +1 more source