Results 31 to 40 of about 44,129 (257)

RhoA/ROCK-1 Signaling Pathway and Oxidative Stress in Coronary Artery Disease Patients

Brazilian Journal of Cardiovascular Surgery, 2021
Introduction: Coronary artery disease (CAD) is an ischemic condition that occurs as a result of partial or complete interruption of blood flow by narrowing or complete blockage of the vessels supplying the heart, which are called coronary arteries.
Eda Dokumacioglu, Ibrahim Duzcan, Hatice Iskender, Arzu Sahin   +3 more
doaj   +1 more source

Janus kinase 2 inhibition by pacritinib as potential therapeutic target for liver fibrosis

Hepatology, EarlyView., 2022
Diagram of the activation of the profibrotic and procontractile Janus kinase 2 (JAK2)/Ras homolog family member A/Rho‐kinase pathway and the inhibition of phosphorylated JAK2 by pacritinib to inhibit hepatic stellate cell activity. Abstract Background and Aims Janus kinase 2 (JAK2) signaling is increased in human and experimental liver fibrosis with ...
Sandra Torres, Cristina Ortiz, Nadine Bachtler, Wenyi Gu, Leon D. Grünewald, Nico Kraus, Robert Schierwagen, Christoph Hieber, Caroline Meier, Olaf Tyc, Maximilian Joseph Brol, Frank Erhard Uschner, Bart Nijmeijer, Christoph Welsch, Marie‐Luise Berres, Carmen Garcia‐Ruiz, Jose Carlos Fernandez‐Checa, Christian Trautwein, Thomas J. Vogl, Stefan Zeuzem, Jonel Trebicka, Sabine Klein   +21 more
wiley   +1 more source

Platelet Rho GTPase regulation in physiology and disease

Platelets, 2019
Rho GTPases are master orchestrators of cytoskeletal dynamics and serve critical roles in platelet physiology to promote hemostasis or pathology in thrombotic, inflammatory and other disease states.
Joseph E. Aslan
doaj   +1 more source

LIM Kinases, LIMK1 and LIMK2, Are Crucial Node Actors of the Cell Fate: Molecular to Pathological Features

Cells, 2023
LIM kinase 1 (LIMK1) and LIM kinase 2 (LIMK2) are serine/threonine and tyrosine kinases and the only two members of the LIM kinase family. They play a crucial role in the regulation of cytoskeleton dynamics by controlling actin filaments and microtubule ...
Elodie Villalonga, Christine Mosrin, Thierry Normand, Caroline Girardin, Amandine Serrano, Bojan Žunar, Michel Doudeau, Fabienne Godin, Hélène Bénédetti, Béatrice Vallée   +9 more
doaj   +1 more source

Integrated proteomics and phosphoproteomics revealed druggable kinases in neoadjuvant chemotherapy resistant tongue cancer

Frontiers in Cell and Developmental Biology, 2022
Tongue squamous cell carcinoma is an aggressive oral cancer with a high incidence of metastasis and poor prognosis. Most of the oral cavity cancer patients present in clinics with locally advanced unresectable tumors.
Irene A. George, Irene A. George, Gajanan Sathe, Gajanan Sathe, Vivek Ghose, Vivek Ghose, Anuradha Chougule, Pratik Chandrani, Vijay Patil, Vanita Noronha, R. Venkataramanan, Sewanti Limaye, Akhilesh Pandey, Akhilesh Pandey, Akhilesh Pandey, Akhilesh Pandey, Kumar Prabhash, Prashant Kumar, Prashant Kumar, Prashant Kumar   +19 more
doaj   +1 more source

Rho-Associated Kinase 2 Polymorphism in Patients With Vasospastic Angina [PDF]

Korean Circulation Journal, 2012
Recent studies indicate that in response to vasoconstrictor stimuli, the small GTPase RhoA and its down-stream effector, Rho-associated kinase 2 (ROCK)/Rho-kinase, are associated with hypercontraction of the vascular smooth muscle of coronary arteries through augmentation of myosin light chain phosphorylation and Ca(2+) sensitization.
Yoo, Sang-Yong, Kim, Jeonguk, Cheong, Sangsig, Shin, Dae-Hee, Jang, Jinkun, Lee, Changkun, Tahk, Seung-Jea, Shin, Joon-Han, Choi, So-Yeon, Yoon, Myeong-Ho   +9 more
openaire   +2 more sources

PAK6: a potential anti-cancer target

Brazilian Journal of Pharmaceutical Sciences, 2020
p21-activated kinase 6 (PAK6) is a member of the PAK family of serine/threonine kinases that are known effectors of Rho GTPases Cdc42 and Rac. PAKs regulate a large number of complex cellular mechanisms, including cell motility, morphology, and tumor ...
Chan-Chan Gong, Tong-Tong Li, Dong-Sheng Pei   +2 more
doaj   +1 more source

Rho-associated protein kinases play an important role in the differentiation of rat adipose-derived stromal cells into cardiomyocytes in vitro. [PDF]

PLoS ONE, 2014
Adipose-derived stromal cells (ADSCs) represent a readily available abundant supply of mesenchymal stem cells and have the ability to differentiate into cardiomyocytes in mice and human, making ADSCs a promising source of cardiomyocytes for ...
Lili Zhao, Gongshe Yang, Xin Zhao
doaj   +1 more source

Wound Contraction Is Attenuated by Fasudil Inhibition of Rho-Associated Kinase [PDF]

Plastic and Reconstructive Surgery, 2011
Dermal scarring and scar contracture result in restriction of movement. There are no effective drugs to prevent scarring. RhoA and Rho-associated kinase have emerged as regulators of fibrosis and contracture. Fasudil, a Rho-associated kinase inhibitor, has been demonstrated to have antifibrotic effects in models of liver, renal, and cardiac fibrosis ...
Jennifer E, Bond, George, Kokosis, Licheng, Ren, M Angelica, Selim, Andrew, Bergeron, Howard, Levinson   +5 more
openaire   +2 more sources

Rho GTPase and Rho Kinase Signaling in Tissue Contractility and Intraocular Pressure Regulation

Frontiers in Bioscience-Landmark
The Rho GTPase and Rho kinase (ROCK) signaling pathway is essential for cellular mechanics, acting as key regulators of the actin cytoskeleton and actomyosin contractility in various cell types and tissues. Rho GTPases, functioning as molecular switches,
Srimathi Raghavan, Padmanabhan P Pattabiraman   +1 more
doaj   +1 more source