Results 111 to 120 of about 82,160 (288)
New Angle of View on the Role of Rho/Rho Kinase Pathway in Human Diseases
Iranian Journal of Allergy, Asthma and Immunology, 2014 Rho-kinase is an effector molecule of RhoA, a monomeric GTP-binding protein, and causes Ca2+ sensitization through inactivation of myosin phosphatase.
Wei Luo +4 more
doaj
Actin re-organization induced by Chlamydia trachomatis serovar D--evidence for a critical role of the effector protein CT166 targeting Rac. [PDF]
PLoS ONE, 2010 The intracellular bacterium Chlamydia trachomatis causes infections of urogenital tract, eyes or lungs. Alignment reveals homology of CT166, a putative effector protein of urogenital C. trachomatis serovars, with the N-terminal glucosyltransferase domain
Jessica Thalmann +7 more
doaj +1 more source
Representing Rod-Shaped Protein 3D Structures in Cylindrical Coordinates [PDF]
arXiv, 2015 Based on overall 3D structure, proteins may be grouped into two broad categories, namely, globular proteins (spheroproteins), and elongated or rod-shaped proteins (RSP). The former comprises a significant majority of proteins. This work concerns the second category. Unlike a spheroprotein, an RSP possesses a conspicuous axis along its longest dimension.
arxiv
, 2007 Biochemistry and mechanics are closely coupled in cell adhesion. At sites of cell-matrix adhesion, mechanical force triggers signaling through the Rho-pathway, which leads to structural reinforcement and increased contractility in the actin cytoskeleton.
Achim Besser +14 more
core +1 more source
Exercise Delays Brain Ageing Through Muscle‐Brain Crosstalk
Cell Proliferation, EarlyView.This graphical abstract illustrates the reciprocal crosstalk between the brain and peripheral organs, highlighting the profound impact of exercise on brain health through systemic interactions. It underscores how exercise influences the brain via signals from various organs and, conversely, how the brain modulates functions of peripheral organs.
Shirin Pourteymour +3 more
wiley +1 more source
PLoS ONE, 2018 Epithelial ovarian cancer (EOC) is the fifth leading cause of cancer mortality in American women. Normal ovarian physiology is intricately connected to small GTP binding proteins of the Ras superfamily (Ras, Rho, Rab, Arf, and Ran) which govern processes
Madalene Earp +148 more
doaj +1 more source
Regulation of Cdc42 for polarized growth in budding yeast
Microbial Cell, 2020 The Rho GTPase Cdc42 is a central regulator of cell polarity in diverse cell types. The activity of Cdc42 is dynamically controlled in time and space to enable distinct polarization events, which generally occur along a single axis in response to spatial
Kristi E. Miller +2 more
doaj +1 more source
Molecular Cancer, 2021 Background DLC1, a tumor suppressor gene that is downregulated in many cancer types by genetic and nongenetic mechanisms, encodes a protein whose RhoGAP and scaffolding activities contribute to its tumor suppressor functions.
Beatriz Sanchez-Solana +6 more
doaj +1 more source
The Small GTP-binding Protein Rho Regulates Cortical Activities in Cultured Cells during Division [PDF]
The Journal of Cell Biology, 1999 We have investigated the role of the small GTP-binding protein Rho in cytokinesis by microinjecting an inhibitor, C3 ribosyltransferase, into cultured cells. Microinjection of C3 into prometaphase or metaphase normal rat kidney epithelial cells induced immediate and global cortical movement of actin toward the metaphase plate, without an apparent ...
O'Connell, Christopher B. +3 more
openaire +4 more sources
Paradoxical signaling regulates structural plasticity in dendritic spines
, 2016 Transient spine enlargement (3-5 min timescale) is an important event associated with the structural plasticity of dendritic spines. Many of the molecular mechanisms associated with transient spine enlargement have been identified experimentally.
Khan, Shahid M. +3 more
core +1 more source