Results 121 to 130 of about 57,806 (244)

Dendritic Cell Migration: An Essential Step in Initiating Adaptive Immunity Across Tissues

Immunological Reviews, Volume 337, Issue 1, January 2026.
ABSTRACT Immune surveillance of tissues is primarily carried out by dendritic cells (DCs), which act as sentinels for the adaptive immune system. To accomplish this task, DCs migrate from tissues to regional lymph nodes, or from blood‐exposed regions of the spleen to the white pulp, to prime T cell responses. DC migration is a tightly regulated process
Eli C. Olson, Adam Williams, Stephanie C. Eisenbarth   +2 more
wiley   +1 more source

Discovering the therapeutic potential of Naringenin in diabetes related to GLUT-4 and its regulatory factors: A computational approach

Chemical Physics Impact
This study explores the therapeutic potential of Naringenin, a natural flavonoid, in managing Type 2 Diabetes Mellitus (T2DM) by focusing on Glucose Transporter 4 (GLUT4) and related regulatory proteins that play a role in glucose and lipid metabolism ...
Ali Khakpour, Shamim Ghiabi, Ali Kazemi Babaheydari, Seyedeh Atefeh Mirahmadi, Payam Baziyar, Ehsan Heidari-Soureshjani, Mohammad Karami Horestani   +6 more
doaj   +1 more source

Polar‐localized EXO70G1 regulates root development in Arabidopsis thaliana

Journal of Integrative Plant Biology, Volume 68, Issue 1, Page 96-112, January 2026.
The putative exocyst subunit EXO70G1 exhibits apical‐basal polarity in Arabidopsis root cells; this polarity stabilizes membrane domains to facilitate targeting of the auxin transporter PIN‐FORMED2 during root development. ABSTRACT Cellular asymmetry, which represents a fundamental characteristic of cell polarity, is prominently illustrated by the ...
Juan Li, Zhendong Liu, Lixue Gong, Shuju Zhao, Qing Lu, Shan Gao, Su Jiang, Xiaonan Liu, Long Ma, Guangyou Duan, Dayong Cui, Shipeng Li   +11 more
wiley   +1 more source

PAKing up to the endothelium [PDF]

, 2009
Angiogenesis recapitulates the growth of blood vessels that progressively expand and remodel into a highly organized and stereotyped vascular network. During adulthood, endothelial cells that formed the vascular wall retain their plasticity and can be ...
Armelle Le Guelte, Eva Maria, Galan Moya, Julie Gavard   +3 more
core   +6 more sources

Translational control in plants: from basic mechanisms to environmental and developmental responses

The Plant Journal, Volume 125, Issue 1, January 2026.
SUMMARY Protein synthesis is an essential process for all living organisms and is tightly regulated to ensure the proper production of proteins needed for growth, development, and stress responses. As sessile organisms, plants have evolved distinct mechanisms to regulate translation, allowing them to adapt to their environment.
Jade Lyons, Catharina Merchante, Anna N. Stepanova, Jose M. Alonso   +3 more
wiley   +1 more source

Activation of platelet phosphatidylinositide 3-kinase requires the small GTP-binding protein Rho.

Journal of Biological Chemistry, 1993
The small GTP-binding protein Rho regulates the assembly of actin stress fibers and focal adhesions in cells responding to growth factors. ADP-ribosylation of Rho by C3 transferase blocks this function; however, an enzymatic target for Rho has not yet been defined.
J, Zhang, W G, King, S, Dillon, A, Hall, L, Feig, S E, Rittenhouse   +5 more
openaire   +2 more sources

Tasco®, a Product of Ascophyllum nodosum, Imparts Thermal Stress Tolerance in Caenorhabditis elegans

Marine Drugs, 2011
Tasco®, a commercial product manufactured from the brown alga Ascophyllum nodosum, has been shown to impart thermal stress tolerance in animals. We investigated the physiological, biochemical and molecular bases of this induced thermal stress tolerance ...
Franklin Evans, Balakrishnan Prithiviraj, Alan T. Critchley, Wajahatullah Khan, Jatinder Singh Sangha, Di Fan, Saveetha Kandasamy   +6 more
doaj   +1 more source

Role of Rac GTPase activating proteins in regulation of NADPH oxidase in human neutrophils [PDF]

, 2014
Precise spatiotemporal regulation of O2 --generating NADPH oxidases (Nox) is a vital requirement. In the case of Nox1-3, which depend on the small GTPase Rac, acceleration of GTP hydrolysis by GTPase activating protein (GAP) could represent a feasible ...
Abo, Ambruso, Banfi, Banfi, Bedard, Bernards, Bernards, Bokoch, Bradford, Connolly, Costa, Csepanyi-Komi, Csepanyi-Komi, Csepanyi-Komi, Cunnick, Diebold, Diekmann, Dupuy, Erzsébet Ligeti, Fuchs, Geiszt, Geiszt, Geiszt, Gorzalczany, Graham, Grizot, Gábor Szarvas, Heyworth, Hjorth, Jaffe, Jaffe, Kiss, Knaus, Koga, Lambeth, Lapouge, Leto, Levay, Levay, Ligeti, Ligeti, Ligeti, Meng, Mittal, Moreno, Moskwa, Nassar, Nauseef, Nemeth, Pettersen, Pick, Rada, Rittinger, Rittinger, Roberts, Scheffzek, Self, Stasia, Sumimoto, Susan M.E. Smith, Szaszi, Takac, Takai, Tcherkezian, Ueyama, Vignais, Voncken, Wolfl, Ákos M. Lőrincz   +68 more
core   +1 more source

ARHGAP11A, a member of Rho GTPase activating protein family, as a prognostic biomarker linked to DNA damage response across pan-cancer

BMC Cancer
Background The Rho GTPase-activating protein (RhoGAP) family represents a large and diverse group of proteins that act as key regulators of Rho GTPases, small GTP-binding proteins involved in cellular signaling. Tight regulation of Rho GTPase activity is
Ke Tan, Yun Wu, Jiaqi Zhang, Yuqiong Ding, Chen Cheng, Zhenyu Yan, Xuetong Wang, Liyuan Zhang   +7 more
doaj   +1 more source

Binding of Vav to Grb2 through dimerization of Src homology 3 domains [PDF]

, 1994
The protooncogenic protein Vav has the structure of an intracellular signal transducer. It is exclusively expressed in cells of hematopoietic lineage and plays a crucial role in hematopoietic cell differentiation.
Baltimore, David, Ye, Zheng-Sheng
core