Results 231 to 240 of about 72,889 (250)
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Rho GTPases in neurodegeneration diseases
Experimental Cell Research, 2013Rho GTPases are molecular switches that modulate multiple intracellular signaling processes by means of various effector proteins. As a result, Rho GTPase activities are tightly spatiotemporally regulated in order to ensure homeostasis within the cell.
Jonathan, DeGeer +1 more
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Rho GTPase Techniques in Osteoclastogenesis
2011Historically, in vitro culturing of primary osteoclasts involved co-culturing of mononuclear monocytes with bone marrow stromal cells, thereby providing the cytokines required for osteoclast formation and multinucleation. Since the identification and cloning of receptor activator of nuclear factor kappa B ligand (RANKL), culturing primary osteoclasts ...
Roland, Leung, Michael, Glogauer
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2017
Rho GTPases control many aspects of cell physiology. This includes polarity, endo/exocytosis, adhesion, motility, transcriptional activation, cell cycle progression or apoptosis. In view of such pleiotropic activities, Rho-controlled signaling has proven to be of medical relevance, especially in tumorigenesis, disease-associated bone remodeling and ...
Fort, Philippe, Blangy, Anne
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Rho GTPases control many aspects of cell physiology. This includes polarity, endo/exocytosis, adhesion, motility, transcriptional activation, cell cycle progression or apoptosis. In view of such pleiotropic activities, Rho-controlled signaling has proven to be of medical relevance, especially in tumorigenesis, disease-associated bone remodeling and ...
Fort, Philippe, Blangy, Anne
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American Journal of Physiology-Lung Cellular and Molecular Physiology, 2004
it is now clear that the Rho family GTPases are important regulators of many cellular functions. In particular, Rho, Rac, and Cdc42 are well-known regulators of the actin cytoskeleton and of cell contraction, adhesion, migration, gene transcription, differentiation, and proliferation.
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it is now clear that the Rho family GTPases are important regulators of many cellular functions. In particular, Rho, Rac, and Cdc42 are well-known regulators of the actin cytoskeleton and of cell contraction, adhesion, migration, gene transcription, differentiation, and proliferation.
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Current Opinion in Cell Biology, 1999
The Rho GTPases are simple enzymes with complex roles in regulating cell morphology, gene transcription, cell cycle progression, apoptosis and tumour progression. The picture has been further complicated by the steady rise in the number of known Rho GTPases as well as in the number of known regulators and target proteins of these GTPases.
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The Rho GTPases are simple enzymes with complex roles in regulating cell morphology, gene transcription, cell cycle progression, apoptosis and tumour progression. The picture has been further complicated by the steady rise in the number of known Rho GTPases as well as in the number of known regulators and target proteins of these GTPases.
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Rho GTPase function in tumorigenesis
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2009Malignant tumor cells display uncontrolled proliferation, loss of epithelial cell polarity, altered interactions with neighboring cells and the surrounding extracellular matrix, and enhanced migratory properties. Proteins of the Rho GTPase family regulate all these processes in cell culture and, for that reason, Rho GTPases, their regulators, and their
Karlsson, R +3 more
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Trends in Genetics, 1994
Ras-related GTP-binding proteins (GTPases) of the rho subfamily play important roles in regulating the organization of the actin cytoskeleton. A large number of multifunctional proteins that can stimulate their intrinsic GTPase activity have been identified.
N, Lamarche, A, Hall
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Ras-related GTP-binding proteins (GTPases) of the rho subfamily play important roles in regulating the organization of the actin cytoskeleton. A large number of multifunctional proteins that can stimulate their intrinsic GTPase activity have been identified.
N, Lamarche, A, Hall
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Rho GTPases and cell migration
Journal of Cell Science, 2001Cell migration involves dynamic and spatially regulated changes to the cytoskeleton and cell adhesion. The Rho GTPases play key roles in coordinating the cellular responses required for cell migration. Recent research has revealed new molecular links between Rho family proteins and the actin cytoskeleton, showing that they act to regulate actin ...
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2005
Preface: The Rho Family List of Contributors Chap 1. Rho GTPases - critical regulators in cell biology Ed Manser Chap 2. Evolution of the human Rho GTPase family: conservation and diversity Stephanie Pellegrin and Harry Mellor Chap 3. Structural analysis of Rho protein complexes Darerca Owen and Helen Mott Chap 4.
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Preface: The Rho Family List of Contributors Chap 1. Rho GTPases - critical regulators in cell biology Ed Manser Chap 2. Evolution of the human Rho GTPase family: conservation and diversity Stephanie Pellegrin and Harry Mellor Chap 3. Structural analysis of Rho protein complexes Darerca Owen and Helen Mott Chap 4.
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Bacterial Toxins Activating Rho GTPases
2005The CNF1 toxin is produced by some uropathogenic (UPECs) andmeningitis-causing Escherichia coli strains. It belongs to a large family of bacterial virulence factors and toxins modifying cellular regulators of the actin cytoskeleton, namely the Rho GTPases. CNF1 autonomously enters the host cell cytosol, where it catalyzes the constitutive activation of
Munro, Patrick, Lemichez, Emmanuel
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