Results 241 to 250 of about 191,346 (272)
Mechanotransduction in Shaping Immunity: Pathways, Crosstalk, and Pathophysiological Relevance
Advanced Science, Volume 12, Issue 41, November 6, 2025.This review comprehensively summarizes the role of mechanotransduction in shaping immunity. It details how immune cells respond to biomechanical cues via mechanotransduction cascades and emphasizes the mechanical crosstalks within the immune microenvironment. The emerging significance of mechanoimmunology in both health and diseases is also highlighted.
Ruijiao Yan +7 more
wiley +1 more source
Amyloid beta binding partners in the brain tissue of older adults
Alzheimer's &Dementia, Volume 21, Issue 11, November 2025.Abstract INTRODUCTION The mechanism linking extracellular amyloid beta (Aβ) with intraneuronal tau tangles, pathological hallmarks of Alzheimer's disease (AD), is not understood; it was tested in the current study through Aβ binding partners. METHODS Data were from decedents of community‐based clinical‐pathological studies.
Shahram Oveisgharan +12 more
wiley +1 more source
Uncovering the secret life of Rho GTPases. [PDF]
Elife, 2019 Perry JA, Maddox AS.
europepmc +1 more source
Cell Surface- and Rho GTPase-Based Auxin Signaling Controls Cellular Interdigitation in Arabidopsis
, 2010 Tongda Xu +9 more
openalex +2 more sources
Conformational Rearrangement of Fission DSPs
BioEssays, Volume 47, Issue 11, November 2025.Assembly properties of fission DSPs. Fission DSPs exist in a dynamic equilibrium of oligomer states in the cytosol, where they must be activated by partner proteins or lipid to induce assembly, and upon GTP hydrolysis, constriction. ABSTRACT Dynamin superfamily proteins (DSPs) are large GTPases that play crucial roles in membrane remodeling processes ...
Anelise N. Hutson +2 more
wiley +1 more source
Mechanism and role of regulated cell death in tumor immunity and immunotherapy
Cancer Communications, Volume 45, Issue 11, Page 1456-1495, November 2025.Abstract Cancer immune checkpoint inhibitors (ICIs) have brought breakthroughs, but only about one‐third of cancer patients benefit from ICIs. In recent years, targeting non‐apoptotic regulated cell death (RCD) subtypes, such as ferroptosis, necroptosis, autophagy, cuproptosis, and pyroptosis, has emerged as a novel strategy in cancer therapy due to ...
Jingwen Hu +4 more
wiley +1 more source
DHCR7 as a Prognostic and Immunological Biomarker in Human Pan‐Cancer: A Comprehensive Evaluation
Cancer Reports, Volume 8, Issue 11, November 2025.ABSTRACT Background The 7‐Dehydrocholesterol reductase (DHCR7), a critical enzyme catalyzing the final step of the cholesterol biosynthesis pathway, has gained attention for its potential role in tumorigenesis. This study systematically investigated the association between DHCR7 expression and oncogenic processes across multiple cancer types.
Xianghua Wu +4 more
wiley +1 more source
Rho GTPases in osteoclasts: Orchestrators of podosome arrangement
, 2008 Stéphane Ory +3 more
openalex +2 more sources
Journal of Extracellular Vesicles, Volume 14, Issue 11, November 2025.H3C14 modulates gemcitabine metabolism and is selectively excluded via extracellular vesicles (EVs) in gemcitabine (GCB)‐resistant bladder cancer. CD9⁺/CD63⁺/CD81⁺ EVs (Transport‐EVs) transmit resistance, whereas CD147⁺/LAMB1⁺ EVs (Excretion‐EVs) excrete tumour‐suppressive cargos, highlighting the functional divergence of EV subtypes in GCB resistance.
Cheng‐Shuo Huang +5 more
wiley +1 more source
Journal of Extracellular Vesicles, Volume 14, Issue 11, November 2025.Radioresistant H3K27M‐pediatric diffuse midline glioma‐derived extracellular vesicles enhance DNA repair and trigger metabolic and transcriptional changes in radiosensitive tumor cells. These findings reveal vesicle‐mediated intratumoral communication as a driver of intrinsic radioresistance and suggest novel targets to disrupt therapy‐resistant ...
Viral D. Oza +6 more
wiley +1 more source