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RHO GTPASES: Biochemistry and Biology
Annual Review of Cell and Developmental Biology, 2005Approximately one percent of the human genome encodes proteins that either regulate or are regulated by direct interaction with members of the Rho family of small GTPases. Through a series of complex biochemical networks, these highly conserved molecular switches control some of the most fundamental processes of cell biology common to all eukaryotes ...
Aron B, Jaffe, Alan, Hall
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Rho GTPases and cell migration
Journal of Cell Science, 2001Cell migration involves dynamic and spatially regulated changes to the cytoskeleton and cell adhesion. The Rho GTPases play key roles in coordinating the cellular responses required for cell migration. Recent research has revealed new molecular links between Rho family proteins and the actin cytoskeleton, showing that they act to regulate actin ...
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2017
Rho GTPases control many aspects of cell physiology. This includes polarity, endo/exocytosis, adhesion, motility, transcriptional activation, cell cycle progression or apoptosis. In view of such pleiotropic activities, Rho-controlled signaling has proven to be of medical relevance, especially in tumorigenesis, disease-associated bone remodeling and ...
Fort, Philippe, Blangy, Anne
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Rho GTPases control many aspects of cell physiology. This includes polarity, endo/exocytosis, adhesion, motility, transcriptional activation, cell cycle progression or apoptosis. In view of such pleiotropic activities, Rho-controlled signaling has proven to be of medical relevance, especially in tumorigenesis, disease-associated bone remodeling and ...
Fort, Philippe, Blangy, Anne
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2005
Rho-family GTPases (p21s) are molecular switches related to the protooncogene Ras: these function in complementary pathways to orchestrate the actin cytoskeleton, regulate cell polarity, microtubule dynamics, membrane transport pathways and modulate a variety of transcriptional events. Rho GTPases are biochemically and structually simple proteins: they
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Rho-family GTPases (p21s) are molecular switches related to the protooncogene Ras: these function in complementary pathways to orchestrate the actin cytoskeleton, regulate cell polarity, microtubule dynamics, membrane transport pathways and modulate a variety of transcriptional events. Rho GTPases are biochemically and structually simple proteins: they
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Rho GTPase Techniques in Osteoclastogenesis
2011Historically, in vitro culturing of primary osteoclasts involved co-culturing of mononuclear monocytes with bone marrow stromal cells, thereby providing the cytokines required for osteoclast formation and multinucleation. Since the identification and cloning of receptor activator of nuclear factor kappa B ligand (RANKL), culturing primary osteoclasts ...
Roland, Leung, Michael, Glogauer
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Rho GTPases in transformation and metastasis
2002During the development and progression of human cancer, cells undergo numerous changes in morphology, proliferation, and transcriptional profile. Over the past couple of decades there have been intense efforts to understand the molecular mechanisms involved, and members of the Ras superfamily of small GTPases have emerged as important players.
Aron B, Jaffe, Alan, Hall
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Regulation of Phagocytosis by Rho GTPases
2005Phagocytosis is the mechanism of internalization used by specialized cells such as macrophages, dendritic cells, and neutrophils to internalize, degrade, and eventually present peptides derived from particulate antigens. The phagocytic process comprises several sequential and complex events initiated by the recognition ofligands on the surface of the ...
F, Niedergang, P, Chavrier
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Rho GTPases and macrophage phagocytosis
2000Publisher Summary This chapter describes Rho guanosine 5'-triphosphates (GTPases) and macrophage phagocytosis. Phagocytosis is the conserved process whereby cells recognize and engulf large particles. It plays a crucial role in diverse functions ranging from feeding in Dictyostelium to removal of apoptotic cells and to host defense mechanisms in ...
J C, Patel, A, Hall, E, Caron
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Rho GTPases and the Actin Cytoskeleton
Science, 1998The actin cytoskeleton mediates a variety of essential biological functions in all eukaryotic cells. In addition to providing a structural framework around which cell shape and polarity are defined, its dynamic properties provide the driving force for cells to move and to divide. Understanding the biochemical mechanisms that control the organization of
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