Results 1 to 10 of about 104,378 (298)

Loss of RhoA in microglia disables glycolytic adaptation and impairs spinal cord injury recovery through Arhgap25/HIF-1α pathway [PDF]

Cell Death and Disease
RhoA, a small GTPase, plays a pivotal role in various diseases, including spinal cord injury (SCI). Although RhoA inhibition has been traditionally viewed as beneficial for SCI repair, recent clinical trials of RhoA inhibitors in SCI have failed to show ...
Jiale Cai, Xinya Zheng, Xiongbo Luo, Wenli Cui, Xinrui Ma, Shuyi Xu, Lanya Fu, Jiaqi Zhang, Yizhou Xu, Yunlun Li, Ye He, Xianghai Wang, Jiasong Guo   +12 more
doaj   +2 more sources

Binding of RHOA G17V to p300 enhances its HAT activity: a new mechanism of epigenetic deregulation in TFH lymphoma [PDF]

Blood Advances
: The RHOA G17V mutation is highly recurrent in T follicular helper (TFH) cell lymphoma of the angioimmunoblastic type (AITL; 60%-70% of cases) and frequently associated with mutations in other T-cell receptor signaling genes, including CD28.
David Vallois, Mélanie Juilland, Kalliopi Ioannidou, François Lemonnier, Edoardo Missiaglia, Bettina Bisig, Margot Thome, Laurence de Leval   +7 more
doaj   +2 more sources

Effects of ICMT gene silencing on the invasion and migration of human salivary adenoid cystic carcinoma cells in vitro

口腔疾病防治, 2023
Objective To investigate the effect of isoprene cysteine carboxymethyltransferase (ICMT) gene on the migration and invasion of salivary adenoid cystic cancer cells (SACC) and the related mechanism, to provide experimental evidence for molecular targeted ...
LU Zhou , GONG Wenhong, XU Xiao, CHEN Zhenggang   +3 more
doaj   +1 more source

Role of HSP27 regulating RhoA in bladder smooth muscle remodeling in rats after bladder outlet obstruction

Di-san junyi daxue xuebao, 2021
Objective To explore the role and underlying mechanism of heat shock protein 27 (HSP27) in bladder smooth muscle remodeling after bladder outlet obstruction (BOO).
LIAO Deyang, WANG Yongquan, XIONG Zhiyong, ZHOU Xiaozhou, HE Peng, ZHOU Zhansong   +5 more
doaj   +1 more source

SUN1/2 Are Essential for RhoA/ROCK-Regulated Actomyosin Activity in Isolated Vascular Smooth Muscle Cells

Cells, 2020
Vascular smooth muscle cells (VSMCs) are the predominant cell type in the blood vessel wall. Changes in VSMC actomyosin activity and morphology are prevalent in cardiovascular disease. The actin cytoskeleton actively defines cellular shape and the LInker
Lauren Porter, Rose-Marie Minaisah, Sultan Ahmed, Seema Ali, Rosemary Norton, Qiuping Zhang, Elisa Ferraro, Chris Molenaar, Mark Holt, Susan Cox, Samuel Fountain, Catherine Shanahan, Derek Warren   +12 more
doaj   +1 more source

CFTR deficiency aggravates Ang II induced vasoconstriction and hypertension by regulating Ca𝟐+ influx and RhoA/Rock pathway in VSMCs

Frontiers in Bioscience-Landmark, 2021
Background: Cystic fibrosis transmembrane conductance regulator (CFTR) has been associated with vascular tone and blood pressure (BP), however, its role in the genesis of hypertension remains elusive.
Liyan Zhao, Feng Yuan, Ni Pan, Yun Yu, Hanyan Yang, Yaosheng Liu, Ruomei Wang, Bin Zhang, Guanlei Wang   +8 more
doaj   +1 more source

Exosomal Dvl3 promoted the aggressive phenotypic transformation of RA-FLS via wnt pathway

Autoimmunity, 2022
Objective This study was performed to explore the function and mechanism of Dvl3 in RA-FLS by exosome intervention. Methods The expression pattern of Dvl3 was examined by IHC, WB, and qPCR.
Weixing Tan, Ning Chen, Yang Qiu, Xiaomei Feng, Shuwen Li, Yongjin Zhang, Haoran Li, Jie Gao, Dongbao Zhao   +8 more
doaj   +1 more source

srGAP2 deactivates RhoA to control the duration of thrombin-mediated endothelial permeability

Vascular Biology, 2022
The endothelial barrier is a tightly regulated gateway in the transport of material between circulation and the tissues. Inflammatory mediators such as thrombin are able to open paracellular spaces in the endothelial monolayer to allow the extravasation ...
Alba Lopez Rioja, Ashton Faulkner, Harry Mellor   +2 more
doaj   +1 more source

Angioimmunoblastic T-cell lymphoma-like lymphadenopathy in mice transgenic for human RHOA with p.Gly17Val mutation

OncoImmunology, 2020
A missense mutation in RHOA encoding p.Gly17 Val has been reported to occur frequently in angioimmunoblastic T-cell lymphoma (AITL). Here, we describe a murine model which expresses the human RHOA mutant gene product in a T-cell specific manner and ...
Gyu Jin Lee, Yukyung Jun, Hae Yong Yoo, Yoon Kyung Jeon, Daekee Lee, Sanghyuk Lee, Jaesang Kim   +6 more
doaj   +1 more source

Effect of miRNA-200b on the proliferation and apoptosis of cervical cancer cells by targeting RhoA

Open Medicine, 2020
This article aims to investigate the effect of miRNA-200b on the proliferation and apoptosis of cervical cancer cells by targeting RhoA.
He Lijie, Wang Jing, Chang Dandan, Lv Dandan, Li Haina, Feng Heqiang   +5 more
doaj   +1 more source