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RhoA Signaling in Neurodegenerative Diseases [PDF]
Cells, 2022 Ras homolog gene family member A (RhoA) is a small GTPase of the Rho family involved in regulating multiple signal transduction pathways that influence a diverse range of cellular functions.
Sissel Ida Schmidt +3 more
doaj +7 more sources
RhoA-ROCK Signaling as a Therapeutic Target in Traumatic Brain Injury
Cells, 2020 Traumatic brain injury (TBI) is a leading cause of death and disability worldwide. TBIs, which range in severity from mild to severe, occur when a traumatic event, such as a fall, a traffic accident, or a blow, causes the brain to move rapidly within the
Shalaka Mulherkar, Kimberley F. Tolias
doaj +2 more sources
Activation of RHOA–VAV1 signaling in angioimmunoblastic T-cell lymphoma [PDF]
Leukemia, 2017 Somatic G17V RHOA mutations were found in 50–70% of angioimmunoblastic T-cell lymphoma (AITL). The mutant RHOA lacks GTP binding capacity, suggesting defects in the classical RHOA signaling.
Enami T +23 more
core +3 more sources
Optogenetic control of RhoA reveals zyxin-mediated elasticity of stress fibres
Nature Communications, 2017 Cytoskeletal mechanics regulates cell morphodynamics and many physiological processes. While contractility is known to be largely RhoA-dependent, the process by which localized biochemical signals are translated into cell-level responses is poorly ...
Patrick W Oakes +2 more
exaly +2 more sources
RHOA lactylation at oncogenic hotspots promotes oncogenic activity and protein stabilization [PDF]
Molecular CancerBackground Aberrant RHOA activation drives tumor progression, yet regulatory mechanisms beyond genetic mutations remain poorly defined. Lactylation, a lactate-derived post-translational modification, links metabolic reprogramming to oncogenesis, but its ...
Chenglong Ma +6 more
doaj +2 more sources
RhoA GTPase switch controls Cx43-hemichannel activity through the contractile system [PDF]
, 2012 ATP-dependent paracrine signaling, mediated via the release of ATP through plasma membrane-embedded hemichannels of the connexin family, coordinates a synchronized response between neighboring cells.
Bultynck, Geert +7 more
core +18 more sources
Piezo2 channel regulates RhoA and actin cytoskeleton to promote cell mechanobiological responses
Proceedings of the National Academy of Sciences of the United States of America, 2018 Carlos Pardo-Pastor +2 more
exaly +2 more sources
Mechanical cues control mutant p53 stability through a mevalonate–RhoA axis
Nature Cell Biology, 2017 Giovanni Sorrentino +2 more
exaly +2 more sources
SARS-CoV-2 Spike Protein Disrupts Blood–Brain Barrier Integrity via RhoA Activation
Journal of Neuroimmune Pharmacology, 2021 The SARS-CoV-2 spike protein has been shown to disrupt blood–brain barrier (BBB) function, but its pathogenic mechanism of action is unknown. Whether angiotensin converting enzyme 2 (ACE2), the viral binding site for SARS-CoV-2, contributes to the spike ...
Brandon J. DeOre +4 more
semanticscholar +1 more source
口腔疾病防治, 2023 Objective To investigate the effect of isoprene cysteine carboxymethyltransferase (ICMT) gene on the migration and invasion of salivary adenoid cystic cancer cells (SACC) and the related mechanism, to provide experimental evidence for molecular targeted ...
LU Zhou +3 more
doaj +1 more source