Results 1 to 10 of about 68,847 (285)
RhoA-ROCK Signaling as a Therapeutic Target in Traumatic Brain Injury
Cells, 2020 Traumatic brain injury (TBI) is a leading cause of death and disability worldwide. TBIs, which range in severity from mild to severe, occur when a traumatic event, such as a fall, a traffic accident, or a blow, causes the brain to move rapidly within the
Shalaka Mulherkar, Kimberley F. Tolias
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RhoA Signaling in Neurodegenerative Diseases
Cells, 2022 Ras homolog gene family member A (RhoA) is a small GTPase of the Rho family involved in regulating multiple signal transduction pathways that influence a diverse range of cellular functions.
Sissel Ida Schmidt +3 more
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Nuclear RhoA Activation Regulates Nucleus Size and DNA Content via Nuclear Activation of ROCK and pErk. [PDF]
CellsRhoA is a major regulator of the actin cytoskeleton. Its function in the nucleus, however, is unclear. Fusing wildtype, fast cycling, constitutively active, and dominant negative forms of RhoA with tags promoting nuclear or cytoplasmic location and ...
Nguyen LP +4 more
europepmc +2 more sources
RhoA/Rho‐kinases in asthma: from pathogenesis to therapeutic targets
Clinical & Translational Immunology, 2020 Asthma is a chronic and heterogeneous disease characterised by airway inflammation and intermittent airway narrowing. The key obstacle in the prevention and treatment of asthma has been our incomplete understanding of its aetiology and biological ...
Yan Zhang +7 more
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口腔疾病防治, 2023 Objective To investigate the effect of isoprene cysteine carboxymethyltransferase (ICMT) gene on the migration and invasion of salivary adenoid cystic cancer cells (SACC) and the related mechanism, to provide experimental evidence for molecular targeted ...
LU Zhou +3 more
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SARS-CoV-2 Spike Protein Disrupts Blood–Brain Barrier Integrity via RhoA Activation
Journal of Neuroimmune Pharmacology, 2021 The SARS-CoV-2 spike protein has been shown to disrupt blood–brain barrier (BBB) function, but its pathogenic mechanism of action is unknown. Whether angiotensin converting enzyme 2 (ACE2), the viral binding site for SARS-CoV-2, contributes to the spike ...
Brandon J. DeOre +4 more
semanticscholar +1 more source
RhoA: a dubious molecule in cardiac pathophysiology
Journal of Biomedical Sciences, 2021 The Ras homolog gene family member A (RhoA) is the founding member of Rho GTPase superfamily originally studied in cancer cells where it was found to stimulate cell cycle progression and migration.
L. Kilian +3 more
semanticscholar +1 more source
Di-san junyi daxue xuebao, 2021 Objective To explore the role and underlying mechanism of heat shock protein 27 (HSP27) in bladder smooth muscle remodeling after bladder outlet obstruction (BOO).
LIAO Deyang +5 more
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Neuropathy-causing TRPV4 mutations disrupt TRPV4-RhoA interactions and impair neurite extension
Nature Communications, 2021 TRPV4 is a cell surface-expressed calcium-permeable cation channel that mediates cell-specific effects on cellular morphology and function. Dominant missense mutations of TRPV4 cause distinct, tissue-specific diseases, but the pathogenic mechanisms are ...
Brett A. McCray +10 more
semanticscholar +1 more source
Frontiers in Bioscience-Landmark, 2021 Background: Cystic fibrosis transmembrane conductance regulator (CFTR) has been associated with vascular tone and blood pressure (BP), however, its role in the genesis of hypertension remains elusive.
Liyan Zhao +8 more
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