Results 1 to 10 of about 99,117 (203)

RhoA Signaling in Neurodegenerative Diseases [PDF]

Cells, 2022
Ras homolog gene family member A (RhoA) is a small GTPase of the Rho family involved in regulating multiple signal transduction pathways that influence a diverse range of cellular functions.
Sissel Ida Schmidt, Morten Blaabjerg, Kristine K Freude   +2 more
exaly   +8 more sources

RhoA accelerates atherosclerosis progression by interacting with Hspa5 [PDF]

Scientific Reports
RhoA has been demonstrated to play a role in atherosclerosis (AS); however, its regulatory mechanisms remain poorly characterized. This study aimed to investigate the function of RhoA in AS and elucidate its underlying mechanisms.
Ruoyu Dong, Can Cao, Jikuan Li, Guangwei Jiang, Yunjie Tian, Xiaoming Shi   +5 more
doaj   +2 more sources

RHOA lactylation at oncogenic hotspots promotes oncogenic activity and protein stabilization [PDF]

Molecular Cancer
Background Aberrant RHOA activation drives tumor progression, yet regulatory mechanisms beyond genetic mutations remain poorly defined. Lactylation, a lactate-derived post-translational modification, links metabolic reprogramming to oncogenesis, but its ...
Chenglong Ma, Ruocen Liao, Xingyu Chen, Qianhua Cao, Xinyue Deng, Zhijun Dai, Chenfang Dong   +6 more
doaj   +2 more sources

RhoA GTPase switch controls Cx43-hemichannel activity through the contractile system [PDF]

, 2012
ATP-dependent paracrine signaling, mediated via the release of ATP through plasma membrane-embedded hemichannels of the connexin family, coordinates a synchronized response between neighboring cells.
Bultynck, Geert, D'Hondt, Catheleyne, Hertens, Fréderic, Himpens, Bernard, Leybaert, Luc, Parys, Jan B, Ponsaerts, Raf, Vereecke, Johan   +7 more
core   +18 more sources

Effects of ICMT gene silencing on the invasion and migration of human salivary adenoid cystic carcinoma cells in vitro

口腔疾病防治, 2023
Objective To investigate the effect of isoprene cysteine carboxymethyltransferase (ICMT) gene on the migration and invasion of salivary adenoid cystic cancer cells (SACC) and the related mechanism, to provide experimental evidence for molecular targeted ...
LU Zhou , GONG Wenhong, XU Xiao, CHEN Zhenggang   +3 more
doaj   +1 more source

Role of HSP27 regulating RhoA in bladder smooth muscle remodeling in rats after bladder outlet obstruction

Di-san junyi daxue xuebao, 2021
Objective To explore the role and underlying mechanism of heat shock protein 27 (HSP27) in bladder smooth muscle remodeling after bladder outlet obstruction (BOO).
LIAO Deyang, WANG Yongquan, XIONG Zhiyong, ZHOU Xiaozhou, HE Peng, ZHOU Zhansong   +5 more
doaj   +1 more source

Granule Cell Dispersion in Human Temporal Lobe Epilepsy: Proteomics investigation of neurodevelopmental migratory pathways [PDF]

, 2020
Granule cell dispersion (GCD) is a common pathological feature observed in the hippocampus of patients with Mesial Temporal Lobe Epilepsy (MTLE). Pathomechanisms underlying GCD remain to be elucidated, but one hypothesis proposes aberrant reactivation of
Al-Kaaby, B., Al-Kaaby, B., Dzurova, N., Dzurova, N., Liu, J., Liu, J., Millks, K., Millks, K., Sisodiya, S.M., Sisodiya, S.M., Thom, M., Thom, M.   +11 more
core   +1 more source

CFTR deficiency aggravates Ang II induced vasoconstriction and hypertension by regulating Ca𝟐+ influx and RhoA/Rock pathway in VSMCs

Frontiers in Bioscience-Landmark, 2021
Background: Cystic fibrosis transmembrane conductance regulator (CFTR) has been associated with vascular tone and blood pressure (BP), however, its role in the genesis of hypertension remains elusive.
Liyan Zhao, Feng Yuan, Ni Pan, Yun Yu, Hanyan Yang, Yaosheng Liu, Ruomei Wang, Bin Zhang, Guanlei Wang   +8 more
doaj   +1 more source

SUN1/2 Are Essential for RhoA/ROCK-Regulated Actomyosin Activity in Isolated Vascular Smooth Muscle Cells

Cells, 2020
Vascular smooth muscle cells (VSMCs) are the predominant cell type in the blood vessel wall. Changes in VSMC actomyosin activity and morphology are prevalent in cardiovascular disease. The actin cytoskeleton actively defines cellular shape and the LInker
Lauren Porter, Rose-Marie Minaisah, Sultan Ahmed, Seema Ali, Rosemary Norton, Qiuping Zhang, Elisa Ferraro, Chris Molenaar, Mark Holt, Susan Cox, Samuel Fountain, Catherine Shanahan, Derek Warren   +12 more
doaj   +1 more source

Exosomal Dvl3 promoted the aggressive phenotypic transformation of RA-FLS via wnt pathway

Autoimmunity, 2022
Objective This study was performed to explore the function and mechanism of Dvl3 in RA-FLS by exosome intervention. Methods The expression pattern of Dvl3 was examined by IHC, WB, and qPCR.
Weixing Tan, Ning Chen, Yang Qiu, Xiaomei Feng, Shuwen Li, Yongjin Zhang, Haoran Li, Jie Gao, Dongbao Zhao   +8 more
doaj   +1 more source