Results 41 to 50 of about 63,147 (208)
Trends in Peptide and Protein Sciences, 2017 Breast cancer is the most prevalent diagnosed cancer and the second cause of cancer death among women worldwide. There are different mechanisms that play crucial roles in the onset and progression of breast cancer including microRNAs. microRNAs are small
Samira Mohammadi Yeganeh +4 more
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Phosphorylation-mediated regulation of GEFs for RhoA [PDF]
Cell Adhesion & Migration, 2013 Spatio-temporal control of RhoA GTPase is critical for regulation of cell migration, attachment to extracellular matrix, and cell-cell adhesions. Activation of RhoA is mediated by guanine nucleotide exchange factors (GEFs), a diverse family of enzymes that are controlled by multiple signaling pathways regulating actin cytoskeleton and cell migration ...
Maulik, Patel, Andrei V, Karginov
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RhoA of the Rho family small GTPases is essential for B lymphocyte development. [PDF]
PLoS ONE, 2012 RhoA is a member of the Rho family small GTPases that are implicated in various cell functions including proliferation and survival. However, the physiological role of RhoA in vivo remains largely unknown.
Shuangmin Zhang +3 more
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Pathogens, 2019 Bacterial meningitis is currently recognized as one of the most important life-threatening infections of the central nervous system (CNS) with high morbidity and mortality, despite the advancements in antimicrobial treatment.
Lu Liu +9 more
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Dissecting the thermodynamics of GAP–RhoA interactions [PDF]
Journal of Structural Biology, 2009 We describe a detailed study of the RhoA-binding epitope of the GAP domain of Graf, including the determination of the thermodynamic and kinetic parameters of the interaction of wild-type domain, and of its 15 single-site mutants, with cognate GTPases. We show that residues important for the structural integrity of the Arg-finger loop are critical for ...
Filip, Jelen +5 more
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, 2007 Textual: Report, copy; 11” x 8.5” (27.9 cm x 21.6 cm)Report from RHOA and RCA Land Use Committee entitled "Final Report of the RHOA and RCA Land Use Committee" dated May 1984. This report, submitted to the boards of the Reston Home Owners Association and
RHOA and RCA Land Use Committee
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Induced Remodelling of Astrocytes In Vitro and In Vivo by Manipulation of Astrocytic RhoA Activity
Cells, 2023 Structural changes of astrocytes and their perisynaptic processes occur in response to various physiological and pathophysiological stimuli. They are thought to profoundly affect synaptic signalling and neuron-astrocyte communication.
Cátia Domingos +8 more
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Cholecystokinin-mediated RhoGDI phosphorylation via PKCα promotes both RhoA and Rac1 signaling. [PDF]
PLoS ONE, 2013 RhoA and Rac1 have been implicated in the mechanism of CCK-induced amylase secretion from pancreatic acini. In all cell types studied to date, inactive Rho GTPases are present in the cytosol bound to the guanine nucleotide dissociation inhibitor RhoGDI ...
Maria Eugenia Sabbatini, John A Williams
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The Functional Significance of the Rho/Rho-Kinase Pathway in Human Erythrocytes
Turkish Journal of Hematology, 2014 OBJECTIVE: Erythrocyte deformability, which can be influenced by various intracellular signaling mechanisms, such as nitric oxide, cAMP, cGMP, and protein kinases, is the most important physiological factor providing the blood flow in microcirculation ...
R. Nalan Tiftik +3 more
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Vav2 Is an Activator of Cdc42, Rac1, and RhoA [PDF]
Journal of Biological Chemistry, 2000 Vav and Vav2 are members of the Dbl family of proteins that act as guanine nucleotide exchange factors (GEFs) for Rho family proteins. Whereas Vav expression is restricted to cells of hematopoietic origin, Vav2 is widely expressed. Although Vav and Vav2 share highly related structural similarities and high sequence identity in their Dbl homology ...
K, Abe +7 more
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