Results 41 to 50 of about 52,817 (240)

Induced Remodelling of Astrocytes In Vitro and In Vivo by Manipulation of Astrocytic RhoA Activity

Cells, 2023
Structural changes of astrocytes and their perisynaptic processes occur in response to various physiological and pathophysiological stimuli. They are thought to profoundly affect synaptic signalling and neuron-astrocyte communication.
Cátia Domingos, Franziska E. Müller, Stefan Passlick, Dagmar Wachten, Evgeni Ponimaskin, Martin K. Schwarz, Susanne Schoch, André Zeug, Christian Henneberger   +8 more
doaj   +1 more source

Dissecting the thermodynamics of GAP–RhoA interactions [PDF]

Journal of Structural Biology, 2009
We describe a detailed study of the RhoA-binding epitope of the GAP domain of Graf, including the determination of the thermodynamic and kinetic parameters of the interaction of wild-type domain, and of its 15 single-site mutants, with cognate GTPases. We show that residues important for the structural integrity of the Arg-finger loop are critical for ...
Filip, Jelen, Pawel, Lachowicz, Wlodzimierz, Apostoluk, Agnieszka, Mateja, Zygmunt S, Derewenda, Jacek, Otlewski   +5 more
openaire   +2 more sources

Ras Homolog Family Member A Regulates Interleukin-6 Expression in Streptozotocin-Pretreated Mice with Relevance to Alzheimer’s Disease-Related Inflammation

Zanco Journal of Medical Sciences
Background and objective: Alzheimer's disease (AD) is a slowly worsening brain disorder linked to ongoing inflammation, with interleukin-6 (IL-6) playing a significant role in its progression.
Kanyaw Abdulrahman, Rundk Hwaiz
doaj   +1 more source

Cholecystokinin-mediated RhoGDI phosphorylation via PKCα promotes both RhoA and Rac1 signaling. [PDF]

PLoS ONE, 2013
RhoA and Rac1 have been implicated in the mechanism of CCK-induced amylase secretion from pancreatic acini. In all cell types studied to date, inactive Rho GTPases are present in the cytosol bound to the guanine nucleotide dissociation inhibitor RhoGDI ...
Maria Eugenia Sabbatini, John A Williams
doaj   +1 more source

Vav2 Is an Activator of Cdc42, Rac1, and RhoA [PDF]

Journal of Biological Chemistry, 2000
Vav and Vav2 are members of the Dbl family of proteins that act as guanine nucleotide exchange factors (GEFs) for Rho family proteins. Whereas Vav expression is restricted to cells of hematopoietic origin, Vav2 is widely expressed. Although Vav and Vav2 share highly related structural similarities and high sequence identity in their Dbl homology ...
K, Abe, K L, Rossman, B, Liu, K D, Ritola, D, Chiang, S L, Campbell, K, Burridge, C J, Der   +7 more
openaire   +2 more sources

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

The Functional Significance of the Rho/Rho-Kinase Pathway in Human Erythrocytes

Turkish Journal of Hematology, 2014
OBJECTIVE: Erythrocyte deformability, which can be influenced by various intracellular signaling mechanisms, such as nitric oxide, cAMP, cGMP, and protein kinases, is the most important physiological factor providing the blood flow in microcirculation ...
R. Nalan Tiftik, Oğuz K. Başkurt, Seval Kul, Kansu Büyükafşar   +3 more
doaj   +1 more source

Triangular Index Ratio as an Alternative Method to the Alpha Angle for Defining the Presence of Cam Morphology: A Prospective Cohort Study

Arthritis Care &Research, EarlyView.
Objective Cam morphology, which is a significant risk factor for hip osteoarthritis, is commonly quantified by the alpha angle (AA). This study aims to explore the potential of the triangular index ratio (TIR) to quantify cam morphology on anteroposterior radiographs by assessing the association between TIR‐defined cam morphology and the development of
Jinchi Tang, Fleur Boel, Michiel M. A. van Buuren, Noortje S. Riedstra, Myrthe A. van den Berg, Jos Runhaar, Sita Bierma‐Zeinstra, Rintje Agricola   +7 more
wiley   +1 more source

Cellular Responses to Mechanical Cues Across Scales: From Fundamental Insights to Translational Potential

Advanced Healthcare Materials, EarlyView.
This review examines how cellular behavior is regulated by mechanical cues transmitted through soft biomaterials, from single‐cell mechanosensing to tissue‐level adaptation. It highlights why physiological relevance, rather than model complexity alone, is critical for translational mechanobiology and introduces a scoring framework linking material ...
Mathias Polz, Manuel P. Kainz, Niklas Haider, Theresa Rienmüller, Kerstin Lenk, Rupert Kargl, Michele Terzano, Gerhard Sommer, Gerhard A. Holzapfel, Julia Fuchs   +9 more
wiley   +1 more source

The versatility of RhoA activities in neural differentiation [PDF]

Small GTPases, 2017
In this commentary we discuss a paper we published recently on the activities of the GTPase RhoA during neural differentiation of murine embryonic stem cells, and relate our findings to previous studies. We narrate how we found that RhoA impedes neural differentiation by inhibiting the production as well as the secretion of noggin, a soluble factor ...
Arie Horowitz, Junning Yang, Jingli Cai, Lorraine Iacovitti   +3 more
openaire   +2 more sources