Results 51 to 60 of about 63,147 (208)

Activation of Rac-1 and RhoA contributes to podocyte injury in chronic kidney disease

, 2013
Rho-family GTPases like RhoA and Rac-1 are potent regulators of cellular signaling that control gene expression, migration and inflammation. Activation of Rho-GTPases has been linked to podocyte dysfunction, a feature of chronic kidney diseases (CKD). We
Liliana Schäfer, Christian Fork (70601), Brandes, Ralf P., Brandes, Ralf, Schäfer, Liliana, Pavenstädt, Hermann, Kerstin Amann, Felix Jansen, Kerstin Sander (481042), Jung, Oliver, Ralf P Brandes, Holger Stark, Hermann Pavenstädt, Löhn, Matthias, Oliver Plettenburg (481045), Plettenburg, Oliver, Hartmut Ruetten (481044), Felix Jansen (362745), Holger Stark (4694), Christoph Daniel (282746), Liliana Schäfer (481043), Kerstin Amann (186160), Oliver Jung (362744), Ralf P. Brandes (362753), Kerstin Sander, Oliver Jung, Fork, Christian, Babelova, Andrea, Matthias Löhn, Hermann Pavenstädt (108698), Sander, Kerstin, Ruetten, Hartmut, Oliver Plettenburg, Hartmut Ruetten, Jansen, Felix, Andrea Babelova, Christian Fork, Stark, Holger, Christoph Daniel, Matthias Löhn (171195), Andrea Babelova (362749), Daniel, Christoph, Amann, Kerstin   +42 more
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Role of Macrophages and RhoA Pathway in Atherosclerosis [PDF]

International Journal of Molecular Sciences, 2020
The development, progression, or stabilization of the atherosclerotic plaque depends on the pro-inflammatory and anti-inflammatory macrophages. The influx of the macrophages and the regulation of macrophage phenotype, inflammatory or anti-inflammatory, are controlled by the small GTPase RhoA and its downstream effectors.
Malgorzata Kloc, Ahmed Uosef, Jacek Z. Kubiak, Rafik Mark Ghobrial   +3 more
openaire   +3 more sources

The effects of RhoA phosphorylation on the activation of RhoA.

, 2016
(A) The activity of wild type and various mutant RhoA proteins in response to EGF. COS-7 cells were transfected with expression constructs encoding wild type and mutant GFP-tagged RhoA proteins.
Junfeng Tong (805234), Barbara Ballermann (2185714), Zhixiang Wang (307861), Laiji Li (2185711)   +3 more
core   +1 more source

Mechanism of RhoA regulating benign prostatic hyperplasia: RhoA-ROCK-β-catenin signaling axis and static & dynamic dual roles

Molecular Medicine, 2023
Background The pathogenesis of benign prostatic hyperplasia (BPH) has not been fully elucidated. Ras homology family member A (RhoA) plays an important role in regulating cell cytoskeleton, growth and fibrosis.
Shidong Shan, Min Su, Yan Li, Zhen Wang, Daoquan Liu, Yongying Zhou, Xun Fu, Shu Yang, Junchao Zhang, Jizhang Qiu, Huan Liu, Guang Zeng, Ping Chen, Xinghuan Wang, Michael E. DiSanto, Yuming Guo, Xinhua Zhang   +16 more
doaj   +1 more source

Variegated RHOA mutations in human cancers [PDF]

Experimental Hematology, 2016
RHOA is one of the most extensively investigated members of the Rho GTPase family of proteins and has long been implicated in malignant transformation as well as tumor invasion and metastasis. Recently, revolutionized sequencing platforms have revealed frequent RHOA mutations in a wide variety of human cancers, including angio-immunoblastic T-cell ...
Keisuke, Kataoka, Seishi, Ogawa
openaire   +2 more sources

Stretching Induces Overexpression of RhoA and Rac1 GTPases in Breast Cancer Cells

, 2019
Rho GTPases are well known for regulating cell morphology and intracellular interactions. They can either be oncogenic or tumor suppressors. However, these proteins are associated with the acquirement of malignant features by cancer cells.
Barton, Matthew, Nam‐Trung Nguyen, Matthew Barton, Nam-Trung, Nguyen, Sharda Yadav, Yadav, Sharda   +5 more
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ANLN Directly Interacts with RhoA to Promote Doxorubicin Resistance in Breast Cancer Cells

Cancer Management and Research, 2020
Feng Wang,* Zhen Xiang,* Teng Huang,* Min Zhang, Wei-Bing Zhou Department of Oncology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, People’s Republic of China*These authors contributed equally to this workCorrespondence: Wei ...
Wang F, Xiang Z, Huang T, Zhang M, Zhou WB   +4 more
doaj  

RhoA G17E/Vav1 Signaling Induces Cancer Invasion via Matrix Metalloproteinase-9 in Gastric Cancer

Technology in Cancer Research & Treatment, 2023
Background: RAS homolog family member A (RhoA), a member of the Rho family of small GTPases, and Vav1, a guanine nucleotide exchange factor for Rho family GTPases, have been reported to activate pathways related to the actin cytoskeleton and regulation ...
Satoshi Nakamura MD, Masato Kitazawa MD, PhD, Yusuke Miyagawa MD, PhD, Makoto Koyama MD, PhD, Satoru Miyazaki MD, Nao Hondo MD, Futoshi Muranaka MD, PhD, Shigeo Tokumaru MD, Yuta Yamamoto MD, PhD, Takehito Ehara MD, PhD, Tomio Matsumura PhD, Michiko Takeoka PhD, Yuji Soejima MD, PhD   +12 more
doaj   +1 more source

Control of RhoA Methylation by Carboxylesterase I [PDF]

Journal of Biological Chemistry, 2013
A number of proteins that play key roles in cell signaling are post-translationally modified by the prenylation pathway. The final step in this pathway is methylation of the carboxyl terminus of the prenylated protein by isoprenylcysteine carboxylmethyltransferase.
Cushman, I., Cushman, S.M., Potter, P.M., Casey, P.J.   +3 more
openaire   +2 more sources

RhoA regulation in space and time

FEBS Letters, 2023
RhoGTPases are well known for being controllers of cell cytoskeleton and share common features in the way they act and are controlled. These include their switch from GDP to GTP states, their regulations by different guanine exchange factors (GEFs), GTPase‐activating proteins and guanosine dissociation inhibitors (GDIs), and their similar structure of ...
Jean de Seze, Joséphine Gatin, Mathieu Coppey   +2 more
openaire   +2 more sources