Results 61 to 70 of about 63,147 (208)
PKCα-Mediated Downregulation of RhoA Activity in Depolarized Vascular Smooth Muscle: Synergistic Vasorelaxant Effect of PKCα and ROCK Inhibition [PDF]
, 2019 [Background/Aims] Protein kinase C (PKC)- and RhoA/Rho-associated kinase (ROCK) play important roles in arterial sustained contraction. Although depolarization-elicited RhoA/ROCK activation is accepted, the role of PKC in depolarized vascular smooth ...
Porras González, Cristina +13 more
core +1 more source
Graded RhoA GTPase Expression in Treg Cells Distinguishes Tumor Immunity From Autoimmunity
Frontiers in Immunology, 2021 RhoA of the Rho GTPase family is prenylated at its C-terminus. Prenylation of RhoA has been shown to control T helper 17 (Th17) cell-mediated colitis. By characterizing T cell-specific RhoA conditional knockout mice, we have recently shown that RhoA is ...
Khalid W. Kalim +6 more
doaj +1 more source
The versatility of RhoA activities in neural differentiation [PDF]
Small GTPases, 2017 In this commentary we discuss a paper we published recently on the activities of the GTPase RhoA during neural differentiation of murine embryonic stem cells, and relate our findings to previous studies. We narrate how we found that RhoA impedes neural differentiation by inhibiting the production as well as the secretion of noggin, a soluble factor ...
Arie Horowitz +3 more
openaire +2 more sources
, 2016 (A-D) Washed human platelets were incubated with U46619 (0.01 μM) for one minute. The reactions were terminated by adding ice-cold HEPES-buffered Tyrode’s solution containing protease inhibitors cocktail.
Yi Zheng (113896) +4 more
core +1 more source
The Small GTPase RHOA in cancer [PDF]
, 2022 RhoA és una proteïna GTPasa amb un paper rellevant en importants processos cel·lulars. Els nivells d’expressió de RhoA i/o la seva activitat es troben alterats en molts tipus de càncer, però curiosament s’han trobat mutacions recurrents i específiques de
Anguita Espinosa, Estefanía +1 more
core
PLoS ONE, 2015 Numerous cellular studies have indicated that RhoA signaling is required for oncogenic Ras-induced transformation, suggesting that RhoA is a useful target in Ras induced neoplasia.
Inuk Zandvakili +3 more
doaj +1 more source
RhoA-GTPase Modulates Neurite Outgrowth by Regulating the Expression of Spastin and p60-Katanin
Cells, 2020 RhoA-GTPase (RhoA) is widely regarded as a key molecular switch to inhibit neurite outgrowth by rigidifying the actin cytoskeleton. However, during neurite outgrowth, whether and how microtubule dynamics are regulated by RhoA remains to be elucidated ...
Dandan Tan +9 more
doaj +1 more source
OncoImmunology, 2022 Angioimmunoblastic T-cell lymphoma (AITL) is a malignant hematologic tumor arising from T follicular helper (Tfh) cells. High-throughput genomic sequencing studies have shown that AITL is characterized by a novel highly recurring somatic mutation in RHOA,
Fenglian Que +5 more
doaj +1 more source
Regulation of mitochondria distribution by RhoA and formins [PDF]
Journal of Cell Science, 2006 The distribution of mitochondria is strictly controlled by the cell because of their vital role in energy supply, regulation of cytosolic Ca2+ concentration and apoptosis. We employed cultured mammalian CV-1 cells and Drosophila BG2-C2 neuronal cells with enhanced green fluorescent protein (EGFP)-tagged mitochondria to investigate the regulation of ...
Alexander A, Minin +5 more
openaire +2 more sources
, 2015 (A) A RhoA bead pull down assay revealed lowered levels of activated RhoA in Ibuprofen treated cells. Treatment with downstream Rho kinase inhibitor Y-27632 showed no difference in RhoA level compared to control.
Hannah Scheiblich (150231) +5 more
core +1 more source