Results 31 to 40 of about 63,147 (208)

Activation of RhoA and SAPK/JNK signalling pathways by the RhoA-specific exchange factor mNET1 [PDF]

The EMBO Journal, 1998
We have characterized the DH domain protein mNET1, a Rho-family guanine nucleotide exchange factor (GEF). N-terminal truncation of mNET1 generates an activated transforming form of the protein, mNET1DeltaN, which acts as a GEF for RhoA but not Cdc42 or Rac1.
A S, Alberts, R, Treisman
openaire   +2 more sources

RhoA in aneurysmal subarachnoid hemorrhage

Aging, 2019
Aneurysmal subarachnoid haemorrhage (aSAH) is a severe subtype of stroke, mediated by the spontaneous rupture of an intracranial aneurysm, that frequently occurs in people between 40 and 60 years of age. Cerebral vasospasm (CV), and related delayed cerebral ischemia (DCI), is a clinical syndrome of the focal neurologic deficits that develop typically ...
Ureña, Juan, Gonzalez-Montelongo, Maria Del Carmen, Murillo-Cabezas, Francisco   +2 more
openaire   +4 more sources

Thrombin-induced Rapid Geranylgeranylation of RhoA as an Essential Process for RhoA Activation in Endothelial Cells [PDF]

Journal of Biological Chemistry, 2005
RhoA plays a critical signaling role in thrombin-induced endothelial dysfunction. The possible thrombin regulation of geranylgeranylation, a lipid modification, of unprocessed RhoA and the significance of the geranylgeranylation in RhoA activation in endothelial cells (ECs) are not well understood.
Hiroshi, Ohkawara, Toshiyuki, Ishibashi, Takayuki, Sakamoto, Koichi, Sugimoto, Kenji, Nagata, Keiko, Yokoyama, Nobuo, Sakamoto, Masashi, Kamioka, Isao, Matsuoka, Shigetomo, Fukuhara, Naotoshi, Sugimoto, Yoh, Takuwa, Yukio, Maruyama   +12 more
openaire   +2 more sources

Survival of the resilient: Mechano-adaptation of circulating tumor cells to fluid shear stress

Molecular & Cellular Oncology, 2020
During metastasis, cancer cells traverse the circulation to reach distant organs. Conventionally, this journey has been regarded as mechanically destructive to circulating tumor cells from solid tissues.
Devon L. Moose, Michael D. Henry
doaj   +1 more source

p66Shc mediates anoikis through RhoA [PDF]

The Journal of Cell Biology, 2007
Detachment of parenchymal cells from a solid matrix switches contextual cues from survival to death during anoikis. Marked shape changes accompany detachment and are thought to trigger cell death, although a working model to explain the coordination of attachment sensation, shape change, and cell fate is elusive.
Ma, Zhenyi, Myers, David P., Wu, Ru Feng, Nwariaku, Fiemu E., Terada, Lance S.   +4 more
openaire   +2 more sources

RhoA-ROCK and p38MAPK-MSK1 mediate vitamin D effects on gene expression, phenotype, and Wnt pathway in colon cancer cells [PDF]

, 2008
The active vitamin D metabolite 1,25-dihydroxy-vitamin D-3 (1,25(OH)(2)D-3) inhibits proliferation and promotes differentiation of colon cancer cells through the activation of vitamin D receptor (VDR), a transcription factor of the nuclear receptor ...
Ruth A. Valero, Carlos Villalobos, María Teresa Berciano, María Jesús Larriba, Villalobos Jorge, Carlos, Valero, Ruth A., Valero, Ruth Ana, Barbáchano Becerril, Antonio, Héctor G. Pálmer, Barbáchano, Antonio, Ordóñez-Morán, Paloma, Villalobos, Carlos, Antonio Barbáchano, Lafarga, Miguel, Mireia Duñach, Duñach, Mireia, Berciano Blanco, María Teresa, Berciano, María Teresa, Muñoz Terol, Alberto, Duñach Masjuan, Mireia, Paloma Ordóñez-Morán, Larriba, María Jesús, Alberto Muñoz, Pálmer, Héctor G., García de Herreros, Antonio, Miguel Lafarga, Berciano, María T., García Palmer, Héctor, Lafarga Coscojuela, Miguel Ángel, Antonio García de Herreros, Ordóñez Morán, Paloma   +30 more
core   +1 more source

Inhibition of the RhoA/Rho-associated, coiled-coil-containing protein kinase-1 pathway is involved in the therapeutic effects of simvastatin on pulmonary arterial hypertension

Clinical and Experimental Hypertension, 2018
Background: Recent research has shown that statins improve pulmonary arterial hypertension (PAH), but their mechanisms of action are not fully understood.
Wei-Hua Liu, Xiao-Hong Xu, Qin Luo, Hong-Liang Zhang, Yong Wang, Qun-Ying Xi, Zhi-Hui Zhao, Zhi-Hong Liu   +7 more
doaj   +1 more source

A transcriptional cross–talk between RhoA and c–Myc inhibits the RhoA/Rock–dependent cytoskeleton [PDF]

Small GTPases, 2010
The GTPase RhoA participates in a number of cellular processes, including cytoskeletal organization, mitogenesis and tumorigenesis. We have previously shown that the transforming activity of an oncogenic version of RhoA (Q63L mutant) was highly dependent on the transcriptional factor c-Myc.
Sauzeau, Vincent, Berenjeno, Inmaculada M., Citterio, Carmen, Bustelo, Xosé R.   +3 more
openaire   +5 more sources

Arp2/3-Branched Actin Maintains an Active Pool of GTP-RhoA and Controls RhoA Abundance

Cells, 2019
Small GTPases regulate cytoskeletal dynamics, cell motility, and division under precise spatiotemporal control. Different small GTPases exhibit cross talks to exert feedback response or to act in concert during signal transduction.
Yuxing Huang, Xin Yi, Chenlu Kang, Congying Wu   +3 more
doaj   +1 more source

RhoA promotes osteoclastogenesis and regulates bone remodeling through mTOR-NFATc1 signaling

Molecular Medicine, 2023
Background The cytoskeletal architecture of osteoclasts (OCs) and bone resorption activity must be appropriately controlled for proper bone remodeling, which is associated with osteoporosis.
Jirong Wang, Chengyun Xu, Jing Zhang, Yizhong Bao, Ying Tang, Xiaoling Lv, Bo Ma, Ximei Wu, Genxiang Mao   +8 more
doaj   +1 more source