Results 21 to 30 of about 63,147 (208)

RhoA: a dubious molecule in cardiac pathophysiology [PDF]

Journal of Biomedical Science, 2021
AbstractThe Ras homolog gene family member A (RhoA) is the founding member of Rho GTPase superfamily originally studied in cancer cells where it was found to stimulate cell cycle progression and migration. RhoA acts as a master switch control of actin dynamics essential for maintaining cytoarchitecture of a cell.
Lucia Sophie Kilian, Jakob Voran, Derk Frank, Ashraf Yusuf Rangrez   +3 more
openaire   +3 more sources

Rac1 and RhoA: Networks, loops and bistability [PDF]

Small GTPases, 2016
Cell migration requires a precise temporal and spatial coordination of several processes which allow the cell to efficiently move. The extension and retraction of membrane protrusion, as well as adhesion are controlled by the Rho-family small GTPases. Two members of the family, Rac1 and RhoA, can show opposite behaviors and spatial localisations, with ...
Nguyen, Lan K., Kholodenko, Boris N., von Kriegsheim, Alex   +2 more
openaire   +3 more sources

Rho GTPases and their downstream effectors in megakaryocyte biology

Platelets, 2019
Megakaryocytes differentiate from hematopoietic stem cells in the bone marrow. The transition of megakaryocytes to platelets is a complex process. Thereby, megakaryocytes extend proplatelets into sinusoidal blood vessels, where the proplatelets undergo ...
Irina Pleines, Deya Cherpokova, Markus Bender   +2 more
doaj   +1 more source

RhoA Proteolysis Regulates the Actin Cytoskeleton in Response to Oxidative Stress. [PDF]

PLoS ONE, 2016
The small GTPase RhoA regulates the actin cytoskeleton to affect multiple cellular processes including endocytosis, migration and adhesion. RhoA activity is tightly regulated through several mechanisms including GDP/GTP cycling, phosphorylation ...
Marie-Pier Girouard, Madeline Pool, Ricardo Alchini, Isabel Rambaldi, Alyson E Fournier   +4 more
doaj   +1 more source

Image_5_Fam65b Phosphorylation Relieves Tonic RhoA Inhibition During T Cell Migration.tif [PDF]

, 2018
We previously identified Fam65b as an atypical inhibitor of the small G protein RhoA. Using a conditional model of a Fam65b-deficient mouse, we first show that Fam65b restricts spontaneous RhoA activation in resting T lymphocytes and regulates intranodal
Cassim, Shamir, Moalli, Federica, Federica Moalli (5526359), El Ghoul, Elyas, Jens V. Stein (3154206), Megrelis, Laura, Jérôme Delon (5735303), Marianne Mangeney (3494330), Nora Ruef (5735300), Laura Megrelis (5735291), Versapuech, Margaux, Elyas El Ghoul (5735294), Ruef, Nora Maria, Stein, Jens Volker, Margaux Versapuech (5735297), Shamir Cassim (3713362), Mangeney, Marianne, Delon, Jérôme   +17 more
core   +1 more source

Review – Nutraceuticals Can Target Asthmatic Bronchoconstriction: NADPH Oxidase-Dependent Oxidative Stress, RhoA and Calcium Dynamics

Journal of Asthma and Allergy, 2021
Mark F McCarty,1 James J DiNicolantonio,2 Aaron Lerner3 1Catalytic Longevity Foundation, San Diego, CA, USA; 2Department of Preventive Cardiology, Saint Luke’s Mid America Heart Institute, Kansas, MO, USA; 3Chaim Sheba Medical Center, The ...
McCarty MF, DiNicolantonio JJ, Lerner A
doaj  

Phosphorylation and Activation of RhoA by ERK in Response to Epidermal Growth Factor Stimulation. [PDF]

PLoS ONE, 2016
The small GTPase RhoA has been implicated in various cellular activities, including the formation of stress fibers, cell motility, and cytokinesis. In addition to the canonical GTPase cycle, recent findings have suggested that phosphorylation further ...
Junfeng Tong, Laiji Li, Barbara Ballermann, Zhixiang Wang   +3 more
doaj   +1 more source

The Small GTPase RHOA Links SLP65 Activation to PTEN Function in Pre B Cells and Is Essential for the Generation and Survival of Normal and Malignant B Cells

Frontiers in Immunology, 2022
The generation, differentiation, survival and activation of B cells are coordinated by signals emerging from the B cell antigen receptor (BCR) or its precursor, the pre-BCR.
Anila Vadakumchery, Hemin Faraidun, Omar El Ayoubi, Issame Outaleb, Vera Schmid, Hend Abdelrasoul, Timm Amendt, Ahmad Khadour, Corinna Setz, Katharina Göhring, Karoline Lodd, Christoffer Hitzing, Alabbas Alkhatib, Mayas Bilal, Julian Benckendorff, Abdul Kader Al Shugri, Cord Herbert Brakebusch, Niklas Engels, Moumita Datta, Elias Hobeika, Ameera Alsadeq, Hassan Jumaa, Hassan Jumaa   +22 more
doaj   +1 more source

Leptin Induces MMP-1 Expression Through the RhoA/ERK1/2/NF-κB Axis in Human Intervertebral Disc Cartilage Endplate-Derived Stem Cells

Journal of Inflammation Research, 2023
Kuo-Feng Hua,1,2,* Lan-Hui Li,3,* Hsin-Chiao Yu,4 Wei-Ting Wong,1 Hsien-Ta Hsu4,5 1Department of Biotechnology and Animal Science, National Ilan University, Yilan, 26047, Taiwan; 2Department of Medical Research, China Medical University Hospital,
Hua KF, Li LH, Yu HC, Wong WT, Hsu HT
doaj  

RhoA promotes epidermal stem cell proliferation via PKN1-cyclin D1 signaling. [PDF]

PLoS ONE, 2017
OBJECTIVE:Epidermal stem cells (ESCs) play a critical role in wound healing, but the mechanism underlying ESC proliferation is not well defined. Here, we explore the effects of RhoA on ESC proliferation and the possible underlying mechanism.
Fan Wang, Rixing Zhan, Liang Chen, Xia Dai, Wenping Wang, Rui Guo, Xiaoge Li, Zhe Li, Liang Wang, Shupeng Huang, Jie Shen, Shirong Li, Chuan Cao   +12 more
doaj   +1 more source