Results 21 to 30 of about 52,817 (240)

Leptin Induces MMP-1 Expression Through the RhoA/ERK1/2/NF-κB Axis in Human Intervertebral Disc Cartilage Endplate-Derived Stem Cells

Journal of Inflammation Research, 2023
Kuo-Feng Hua,1,2,* Lan-Hui Li,3,* Hsin-Chiao Yu,4 Wei-Ting Wong,1 Hsien-Ta Hsu4,5 1Department of Biotechnology and Animal Science, National Ilan University, Yilan, 26047, Taiwan; 2Department of Medical Research, China Medical University Hospital,
Hua KF, Li LH, Yu HC, Wong WT, Hsu HT
doaj  

Phosphorylation and Activation of RhoA by ERK in Response to Epidermal Growth Factor Stimulation. [PDF]

PLoS ONE, 2016
The small GTPase RhoA has been implicated in various cellular activities, including the formation of stress fibers, cell motility, and cytokinesis. In addition to the canonical GTPase cycle, recent findings have suggested that phosphorylation further ...
Junfeng Tong, Laiji Li, Barbara Ballermann, Zhixiang Wang   +3 more
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The Small GTPase RHOA Links SLP65 Activation to PTEN Function in Pre B Cells and Is Essential for the Generation and Survival of Normal and Malignant B Cells

Frontiers in Immunology, 2022
The generation, differentiation, survival and activation of B cells are coordinated by signals emerging from the B cell antigen receptor (BCR) or its precursor, the pre-BCR.
Anila Vadakumchery, Hemin Faraidun, Omar El Ayoubi, Issame Outaleb, Vera Schmid, Hend Abdelrasoul, Timm Amendt, Ahmad Khadour, Corinna Setz, Katharina Göhring, Karoline Lodd, Christoffer Hitzing, Alabbas Alkhatib, Mayas Bilal, Julian Benckendorff, Abdul Kader Al Shugri, Cord Herbert Brakebusch, Niklas Engels, Moumita Datta, Elias Hobeika, Ameera Alsadeq, Hassan Jumaa, Hassan Jumaa   +22 more
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RhoA: a dubious molecule in cardiac pathophysiology [PDF]

Journal of Biomedical Science, 2021
AbstractThe Ras homolog gene family member A (RhoA) is the founding member of Rho GTPase superfamily originally studied in cancer cells where it was found to stimulate cell cycle progression and migration. RhoA acts as a master switch control of actin dynamics essential for maintaining cytoarchitecture of a cell.
Lucia Sophie Kilian, Jakob Voran, Derk Frank, Ashraf Yusuf Rangrez   +3 more
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RhoA promotes epidermal stem cell proliferation via PKN1-cyclin D1 signaling. [PDF]

PLoS ONE, 2017
OBJECTIVE:Epidermal stem cells (ESCs) play a critical role in wound healing, but the mechanism underlying ESC proliferation is not well defined. Here, we explore the effects of RhoA on ESC proliferation and the possible underlying mechanism.
Fan Wang, Rixing Zhan, Liang Chen, Xia Dai, Wenping Wang, Rui Guo, Xiaoge Li, Zhe Li, Liang Wang, Shupeng Huang, Jie Shen, Shirong Li, Chuan Cao   +12 more
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Activation of RhoA and SAPK/JNK signalling pathways by the RhoA‐specific exchange factor mNET1 [PDF]

The EMBO Journal, 1998
We have characterized the DH domain protein mNET1, a Rho-family guanine nucleotide exchange factor (GEF). N-terminal truncation of mNET1 generates an activated transforming form of the protein, mNET1DeltaN, which acts as a GEF for RhoA but not Cdc42 or Rac1.
A S, Alberts, R, Treisman
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RhoA in aneurysmal subarachnoid hemorrhage

Aging, 2019
Aneurysmal subarachnoid haemorrhage (aSAH) is a severe subtype of stroke, mediated by the spontaneous rupture of an intracranial aneurysm, that frequently occurs in people between 40 and 60 years of age. Cerebral vasospasm (CV), and related delayed cerebral ischemia (DCI), is a clinical syndrome of the focal neurologic deficits that develop typically ...
Ureña, Juan, Gonzalez-Montelongo, Maria Del Carmen, Murillo-Cabezas, Francisco   +2 more
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p66Shc mediates anoikis through RhoA [PDF]

The Journal of Cell Biology, 2007
Detachment of parenchymal cells from a solid matrix switches contextual cues from survival to death during anoikis. Marked shape changes accompany detachment and are thought to trigger cell death, although a working model to explain the coordination of attachment sensation, shape change, and cell fate is elusive.
Ma, Zhenyi, Myers, David P., Wu, Ru Feng, Nwariaku, Fiemu E., Terada, Lance S.   +4 more
openaire   +2 more sources

Thrombin-induced Rapid Geranylgeranylation of RhoA as an Essential Process for RhoA Activation in Endothelial Cells [PDF]

Journal of Biological Chemistry, 2005
RhoA plays a critical signaling role in thrombin-induced endothelial dysfunction. The possible thrombin regulation of geranylgeranylation, a lipid modification, of unprocessed RhoA and the significance of the geranylgeranylation in RhoA activation in endothelial cells (ECs) are not well understood.
Hiroshi, Ohkawara, Toshiyuki, Ishibashi, Takayuki, Sakamoto, Koichi, Sugimoto, Kenji, Nagata, Keiko, Yokoyama, Nobuo, Sakamoto, Masashi, Kamioka, Isao, Matsuoka, Shigetomo, Fukuhara, Naotoshi, Sugimoto, Yoh, Takuwa, Yukio, Maruyama   +12 more
openaire   +2 more sources

Survival of the resilient: Mechano-adaptation of circulating tumor cells to fluid shear stress

Molecular & Cellular Oncology, 2020
During metastasis, cancer cells traverse the circulation to reach distant organs. Conventionally, this journey has been regarded as mechanically destructive to circulating tumor cells from solid tissues.
Devon L. Moose, Michael D. Henry
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