Results 11 to 20 of about 63,147 (208)
Histamine-induced biphasic activation of RhoA allows for persistent RhoA signaling. [PDF]
PLoS Biology, 2020 The small GTPase RhoA is a central signaling enzyme that is involved in various cellular processes such as cytoskeletal dynamics, transcription, and cell cycle progression.
Jason Z Zhang +5 more
doaj +6 more sources
RhoA Regulation of Cardiomyocyte Differentiation [PDF]
The Scientific World Journal, 2013 Earlier findings from our laboratory implicated RhoA in heart developmental processes. To investigate factors that potentially regulate RhoA expression, RhoA gene organisation and promoter activity were analysed.
Mari Kaarbø +2 more
doaj +5 more sources
RHOA Therapeutic Targeting in Hematological Cancers [PDF]
Cells, 2023 Primarily identified as an important regulator of cytoskeletal dynamics, the small GTPase Ras homolog gene family member A (RHOA) has been implicated in the transduction of signals regulating a broad range of cellular functions such as cell survival, migration, adhesion and proliferation.
Juliana Carvalho Santos +3 more
openaire +5 more sources
RhoA Is a Crucial Regulator of Myoblast Fusion
Cells, 2023 Satellite cells (SCs) are adult muscle stem cells that are mobilized when muscle homeostasis is perturbed. Here we show that RhoA in SCs is indispensable to have correct muscle regeneration and hypertrophy.
Chiara Noviello +6 more
doaj +4 more sources
Exercise, RhoA and Cardioprotection [PDF]
, 2011 Regular exercise prevents cardiovascular disease (CVD), however the molecular mechanisms to explain the benefits are not well understood. Recent evidence suggests that exercise-induced changes in endothelial cell morphology and function may play a major role in preventing CVD.
Aya Matsumoto
openaire +1 more source
Small GTPases, 2013 Mechanical forces influence nearly all aspects of biology. Cells are equipped with numerous mechanosensitive proteins that activate various signaling cascades in response to mechanical cues from their environment. Much interest lies in understanding how cells respond to external stresses.
Caitlin, Collins, Ellie, Tzima
openaire +2 more sources
, 2023 This research investigated the role of RhoA, a small G-protein, in cardioprotection against ischemic stress and showed that RhoA regulates the PINK1 stability to stimulate mitophagy, providing a cell survival advantage.Mitophagy removes dysfunctional ...
Shigeki Miyamoto (17398333)
core +1 more source
The RhoA transcriptional program in pre-T cells [PDF]
, 2007 The GTPase RhoA is essential for the development of pre-T cells in the thymus. To investigate the mechanisms used by RhoA to control thymocyte development we have used Affymetrix gene profiling to identify RhoA regulated genes in T cell progenitors.
Lightfoot, K. +5 more
core +1 more source
Destruction of RhoA CULtivates Actin [PDF]
Molecular Cell, 2009 Cullin 3, the core subunit of the CRL3 ubiquitin ligase family, is essential for development, but its substrates remain poorly defined. Here, Chen et al. (2009) report that CRL3(BACURD) targets the RhoA GTPase for degradation, thereby maintaining actin cytoskeleton integrity.
Wu, Shuangding, Wolf, Dieter A.
openaire +2 more sources
Integrin Regulation by RhoA in Thymocytes [PDF]
The Journal of Immunology, 2005 Abstract The guanine nucleotide-binding protein Rho has essential functions in T cell development and is important for the survival and proliferation of T cell progenitors in the thymus. To explore the mechanisms used by RhoA to control thymocyte biology, the role of this GTPase in the regulation of integrin-mediated cell adhesion was ...
Vielkind, Susina +4 more
openaire +3 more sources