Results 11 to 20 of about 52,817 (240)
srGAP2 deactivates RhoA to control the duration of thrombin-mediated endothelial permeability
Vascular Biology, 2022 The endothelial barrier is a tightly regulated gateway in the transport of material between circulation and the tissues. Inflammatory mediators such as thrombin are able to open paracellular spaces in the endothelial monolayer to allow the extravasation ...
Alba Lopez Rioja +2 more
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OncoImmunology, 2020 A missense mutation in RHOA encoding p.Gly17 Val has been reported to occur frequently in angioimmunoblastic T-cell lymphoma (AITL). Here, we describe a murine model which expresses the human RHOA mutant gene product in a T-cell specific manner and ...
Gyu Jin Lee +6 more
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RhoA-ROCK Signaling as a Therapeutic Target in Traumatic Brain Injury
Cells, 2020 Traumatic brain injury (TBI) is a leading cause of death and disability worldwide. TBIs, which range in severity from mild to severe, occur when a traumatic event, such as a fall, a traffic accident, or a blow, causes the brain to move rapidly within the
Shalaka Mulherkar, Kimberley F. Tolias
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Destruction of RhoA CULtivates Actin [PDF]
Molecular Cell, 2009 Cullin 3, the core subunit of the CRL3 ubiquitin ligase family, is essential for development, but its substrates remain poorly defined. Here, Chen et al. (2009) report that CRL3(BACURD) targets the RhoA GTPase for degradation, thereby maintaining actin cytoskeleton integrity.
Wu, Shuangding, Wolf, Dieter A.
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Integrin Regulation by RhoA in Thymocytes [PDF]
The Journal of Immunology, 2005 Abstract The guanine nucleotide-binding protein Rho has essential functions in T cell development and is important for the survival and proliferation of T cell progenitors in the thymus. To explore the mechanisms used by RhoA to control thymocyte biology, the role of this GTPase in the regulation of integrin-mediated cell adhesion was ...
Vielkind, Susina +4 more
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Rac1 and RhoA: Networks, loops and bistability [PDF]
Small GTPases, 2016 Cell migration requires a precise temporal and spatial coordination of several processes which allow the cell to efficiently move. The extension and retraction of membrane protrusion, as well as adhesion are controlled by the Rho-family small GTPases. Two members of the family, Rac1 and RhoA, can show opposite behaviors and spatial localisations, with ...
Nguyen, Lan K. +2 more
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Effect of miRNA-200b on the proliferation and apoptosis of cervical cancer cells by targeting RhoA
Open Medicine, 2020 This article aims to investigate the effect of miRNA-200b on the proliferation and apoptosis of cervical cancer cells by targeting RhoA.
He Lijie +5 more
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Rho GTPases and their downstream effectors in megakaryocyte biology
Platelets, 2019 Megakaryocytes differentiate from hematopoietic stem cells in the bone marrow. The transition of megakaryocytes to platelets is a complex process. Thereby, megakaryocytes extend proplatelets into sinusoidal blood vessels, where the proplatelets undergo ...
Irina Pleines +2 more
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Journal of Asthma and Allergy, 2021 Mark F McCarty,1 James J DiNicolantonio,2 Aaron Lerner3 1Catalytic Longevity Foundation, San Diego, CA, USA; 2Department of Preventive Cardiology, Saint Luke’s Mid America Heart Institute, Kansas, MO, USA; 3Chaim Sheba Medical Center, The ...
McCarty MF, DiNicolantonio JJ, Lerner A
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RhoA Proteolysis Regulates the Actin Cytoskeleton in Response to Oxidative Stress. [PDF]
PLoS ONE, 2016 The small GTPase RhoA regulates the actin cytoskeleton to affect multiple cellular processes including endocytosis, migration and adhesion. RhoA activity is tightly regulated through several mechanisms including GDP/GTP cycling, phosphorylation ...
Marie-Pier Girouard +4 more
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