Results 141 to 150 of about 123,069 (394)

Label‐Free Leukocyte Biophysical Profiling Using Impedance‐Deformability Cytometry for Rapid Cardiovascular Risk Stratification

Advanced Science, EarlyView.
This study presents an impedance‐based single‐cell profiling platform that quantifies the electrical and mechanical properties of neutrophils across in vitro, in vivo, and clinical samples. The approach reveals distinct biophysical alterations associated with type 2 diabetes (T2DM) and cardiovascular complications, suggesting its potential utility for ...
Linwei He, Hui Min Tay, Feng Chen, Hong Sheng Cheng, Liang De Wang, Qiqi Nam, Arunachalam Thannirmalai, Lingyan Gong, Aram J. Chung, Nguan Soon Tan, King Ho Holden Li, Rinkoo Dalan, Siu Ling Wong, Han Wei Hou   +13 more
wiley   +1 more source

Heart of glass anchors Rasip1 at endothelial cell-cell junctions to support vascular integrity. [PDF]

, 2016
Heart of Glass (HEG1), a transmembrane receptor, and Rasip1, an endothelial-specific Rap1-binding protein, are both essential for cardiovascular development.
de Kreuk, Bart-Jan, Gingras, Alexandre R, Gingras, Anne-Claude, Ginsberg, Mark H, Knight, James Dr, Liu, Jian J   +5 more
core   +2 more sources

Tobacco Smoke Exposure From Prenatal To Adolescent Periods Drives IBD Pathogenesis: Dynamic DNA Methylation Signatures Across Lifespan Stages

Advanced Science, EarlyView.
This study illustrates that maternal smoking during pregnancy (MSDP) is an independent risk factor for IBD in offspring, and DNA methylation serves as a key mechanistic pathway connecting early‐life smoking exposure with IBD risk in offspring. That highlights the urgent need for preventive interventions targeting prospective parents and minors to ...
Han Zhang, Jianhui Zhao, Jie Chen, Xinyi Ma, Siyun Zhou, Alexandra Noble, Rahul Kalla, Judith Wellens, Kun Liu, Evropi Theodoratou, Jack Satsangi, Xue Li   +11 more
wiley   +1 more source

Nuclear RhoA Activation Regulates Nucleus Size and DNA Content via Nuclear Activation of ROCK and pErk

Cells
RhoA is a major regulator of the actin cytoskeleton. Its function in the nucleus, however, is unclear. Fusing wildtype, fast cycling, constitutively active, and dominant negative forms of RhoA with tags promoting nuclear or cytoplasmic location and ...
Lap P. Nguyen, Julius Svensmark, Xin Jiang, Alexander Jordan, Cord Brakebusch   +4 more
doaj   +1 more source

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

Enriched environment reduces glioma growth through immune and non-immune mechanisms in mice [PDF]

, 2015
Mice exposed to standard (SE) or enriched environment (EE) were transplanted with murine or human glioma cells and differences in tumour development were evaluated.
BENIGNI, GIORGIA, BERNARDINI, Giovanni, Brau, Frederic, CHECE, Giuseppina, D'ALESSANDRO, GIUSEPPINA, ESPOSITO, Vincenzo, GAROFALO, STEFANO, LAURO, CLOTILDE, LIMATOLA, Cristina, MAGGI, Laura, MAINIERO, Fabrizio, PORZIA, Alessandra, ROSA, ALESSANDRO, SANTONI, Angela   +13 more
core   +1 more source

Sporadic Early-Onset Diffuse Gastric Cancers Have High Frequency of Somatic CDH1 Alterations, but Low Frequency of Somatic RHOA Mutations Compared With Late-Onset Cancers

Gastroenterology, 2017
BACKGROUND & AIMS: Early-onset gastric cancer, which develops in patients younger than most gastric cancers, is usually detected at advanced stages, has diffuse histologic features, and occurs more frequently in women.
S. Cho, Jun Won Park, Yang Liu, Y. S. Park, Ju Hee Kim, Hanna Yang, Hyejin Um, W. Ko, Byung Il Lee, S. Kwon, S. Ryu, C. Kwon, D. Park, Jae-Hyuk Lee, Sang Il Lee, K. Song, H. Hur, Sang-Uk Han, Heekyung Chang, Sujin Kim, Byung-Sik Kim, J. Yook, M. Yoo, B. Kim, Inseob Lee, Myeong-Cherl Kook, N. Thiessen, A. He, C. Stewart, Andrew J. Dunford, Jaegil Kim, J. Shih, G. Saksena, A. Cherniack, S. Schumacher, A. Weiner, Mara W Rosenberg, G. Getz, E. Yang, M. Ryu, A. Bass, H. Kim   +41 more
semanticscholar   +1 more source

Ginsenoside Rb1 protects against ischemia/reperfusion-induced myocardial injury via energy metabolism regulation mediated by RhoA signaling pathway

Scientific Reports, 2017
Cardiac ischemia and reperfusion (I/R) injury remains a challenge for clinicians. Ginsenoside Rb1 (Rb1) has been reported to have the ability to attenuate I/R injury, but its effect on energy metabolism during cardiac I/R and the underlying mechanism ...
Yuan‐Chen Cui, C. Pan, Li Yan, Lin Li, Bai-he Hu, Xin Chang, Yu-ying Liu, Jing-yu Fan, Kai Sun, Quan Li, Jing‐Yan Han   +10 more
semanticscholar   +1 more source

Integrin β3 Orchestrates Hepatic Steatosis via a Novel CD36‐Dependent Lipid Uptake Complex

Advanced Science, EarlyView.
In MASH, ITGB3 recruits LYN and drives its ubiquitin‐proteasomal degradation via phosphorylation. This relieves DHHC5 inhibition, enabling ITGB3/DHHC5/CD36 complex assembly to enhance CD36 palmitoylation and fatty acid uptake, thereby exacerbating disease. Targeting ITGB3 blocks this pathogenic axis and ameliorates MASH.
Ying Zhang, Lei Dai, Zhongquan Cui, Ye Zhou, Wenyuan Dong, Hongcheng Jiang, Mengwen Wang, Xiaodan Zhong, Wei Dong, Zhang Yue, Thati Madhusudhan, Hongjie Wang, Xiong Zhong Ruan, Hesong Zeng   +13 more
wiley   +1 more source

Wnt Signaling in Neural Crest Ontogenesis and Oncogenesis. [PDF]

, 2019
Neural crest (NC) cells are a temporary population of multipotent stem cells that generate a diverse array of cell types, including craniofacial bone and cartilage, smooth muscle cells, melanocytes, and peripheral neurons and glia during embryonic ...
Hao, Hongyan, Ji, Yu, McMahon, Moira, Reynolds, Kurt, Zhou, Chengji J   +4 more
core   +2 more sources