Results 11 to 20 of about 99,117 (203)
Histamine-induced biphasic activation of RhoA allows for persistent RhoA signaling. [PDF]
PLoS Biology, 2020 The small GTPase RhoA is a central signaling enzyme that is involved in various cellular processes such as cytoskeletal dynamics, transcription, and cell cycle progression.
Jason Z Zhang +5 more
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Arp2/3-Branched Actin Maintains an Active Pool of GTP-RhoA and Controls RhoA Abundance [PDF]
Cells, 2019 Small GTPases regulate cytoskeletal dynamics, cell motility, and division under precise spatiotemporal control. Different small GTPases exhibit cross talks to exert feedback response or to act in concert during signal transduction.
Yuxing Huang +3 more
doaj +3 more sources
RhoA Regulation of Cardiomyocyte Differentiation [PDF]
The Scientific World Journal, 2013 Earlier findings from our laboratory implicated RhoA in heart developmental processes. To investigate factors that potentially regulate RhoA expression, RhoA gene organisation and promoter activity were analysed.
Mari Kaarbø +2 more
doaj +4 more sources
Small GTPases, 2013 Mechanical forces influence nearly all aspects of biology. Cells are equipped with numerous mechanosensitive proteins that activate various signaling cascades in response to mechanical cues from their environment. Much interest lies in understanding how cells respond to external stresses.
Caitlin, Collins, Ellie, Tzima
openaire +2 more sources
p66Shc mediates anoikis through RhoA [PDF]
The Journal of Cell Biology, 2007 Detachment of parenchymal cells from a solid matrix switches contextual cues from survival to death during anoikis. Marked shape changes accompany detachment and are thought to trigger cell death, although a working model to explain the coordination of attachment sensation, shape change, and cell fate is elusive.
Ma, Zhenyi +4 more
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srGAP2 deactivates RhoA to control the duration of thrombin-mediated endothelial permeability
Vascular Biology, 2022 The endothelial barrier is a tightly regulated gateway in the transport of material between circulation and the tissues. Inflammatory mediators such as thrombin are able to open paracellular spaces in the endothelial monolayer to allow the extravasation ...
Alba Lopez Rioja +2 more
doaj +1 more source
OncoImmunology, 2020 A missense mutation in RHOA encoding p.Gly17 Val has been reported to occur frequently in angioimmunoblastic T-cell lymphoma (AITL). Here, we describe a murine model which expresses the human RHOA mutant gene product in a T-cell specific manner and ...
Gyu Jin Lee +6 more
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RhoA-ROCK Signaling as a Therapeutic Target in Traumatic Brain Injury
Cells, 2020 Traumatic brain injury (TBI) is a leading cause of death and disability worldwide. TBIs, which range in severity from mild to severe, occur when a traumatic event, such as a fall, a traffic accident, or a blow, causes the brain to move rapidly within the
Shalaka Mulherkar, Kimberley F. Tolias
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Destruction of RhoA CULtivates Actin [PDF]
Molecular Cell, 2009 Cullin 3, the core subunit of the CRL3 ubiquitin ligase family, is essential for development, but its substrates remain poorly defined. Here, Chen et al. (2009) report that CRL3(BACURD) targets the RhoA GTPase for degradation, thereby maintaining actin cytoskeleton integrity.
Wu, Shuangding, Wolf, Dieter A.
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Effect of miRNA-200b on the proliferation and apoptosis of cervical cancer cells by targeting RhoA
Open Medicine, 2020 This article aims to investigate the effect of miRNA-200b on the proliferation and apoptosis of cervical cancer cells by targeting RhoA.
He Lijie +5 more
doaj +1 more source