Results 11 to 20 of about 123,069 (394)

Histamine-induced biphasic activation of RhoA allows for persistent RhoA signaling. [PDF]

PLoS Biology, 2020
The small GTPase RhoA is a central signaling enzyme that is involved in various cellular processes such as cytoskeletal dynamics, transcription, and cell cycle progression.
Jason Z Zhang, Andy H Nguyen, Shigeki Miyamoto, Joan Heller Brown, Andrew D McCulloch, Jin Zhang   +5 more
doaj   +5 more sources

Arp2/3-Branched Actin Maintains an Active Pool of GTP-RhoA and Controls RhoA Abundance [PDF]

Cells, 2019
Small GTPases regulate cytoskeletal dynamics, cell motility, and division under precise spatiotemporal control. Different small GTPases exhibit cross talks to exert feedback response or to act in concert during signal transduction.
Yuxing Huang, Xin Yi, Chenlu Kang, Congying Wu   +3 more
doaj   +3 more sources

RhoA Regulation of Cardiomyocyte Differentiation [PDF]

The Scientific World Journal, 2013
Earlier findings from our laboratory implicated RhoA in heart developmental processes. To investigate factors that potentially regulate RhoA expression, RhoA gene organisation and promoter activity were analysed.
Mari Kaarbø, Denis I. Crane, Wayne G. Murrell   +2 more
doaj   +4 more sources

RhoA signaling increases mitophagy and protects cardiomyocytes against ischemia by stabilizing PINK1 protein and recruiting Parkin to mitochondria

Cell Death and Differentiation, 2022
Mitophagy, a mitochondria-specific form of autophagy, removes dysfunctional mitochondria and is hence an essential process contributing to mitochondrial quality control.
Michelle Tu, V. P. Tan, Justin D. Yu, Raghav Tripathi, Zahna Bigham, Melissa Barlow, Jeffrey M. Smith, J. Brown, Shigeki Miyamoto   +8 more
semanticscholar   +1 more source

RhoA: a dubious molecule in cardiac pathophysiology

Journal of Biomedical Sciences, 2021
The Ras homolog gene family member A (RhoA) is the founding member of Rho GTPase superfamily originally studied in cancer cells where it was found to stimulate cell cycle progression and migration.
L. Kilian, J. Voran, D. Frank, A. Rangrez   +3 more
semanticscholar   +1 more source

Neuropathy-causing TRPV4 mutations disrupt TRPV4-RhoA interactions and impair neurite extension

Nature Communications, 2021
TRPV4 is a cell surface-expressed calcium-permeable cation channel that mediates cell-specific effects on cellular morphology and function. Dominant missense mutations of TRPV4 cause distinct, tissue-specific diseases, but the pathogenic mechanisms are ...
Brett A. McCray, E. Diehl, J. M. Sullivan, William H. Aisenberg, Nicholas W. Zaccor, Alexander Lau, Dominick J Rich, B. Goretzki, Ute A. Hellmich, T. Lloyd, C. Sumner   +10 more
semanticscholar   +1 more source

RhoA goes GLOBAL [PDF]

Small GTPases, 2013
Mechanical forces influence nearly all aspects of biology. Cells are equipped with numerous mechanosensitive proteins that activate various signaling cascades in response to mechanical cues from their environment. Much interest lies in understanding how cells respond to external stresses.
Caitlin, Collins, Ellie, Tzima
openaire   +2 more sources

Role of HSP27 regulating RhoA in bladder smooth muscle remodeling in rats after bladder outlet obstruction

Di-san junyi daxue xuebao, 2021
Objective To explore the role and underlying mechanism of heat shock protein 27 (HSP27) in bladder smooth muscle remodeling after bladder outlet obstruction (BOO).
LIAO Deyang, WANG Yongquan, XIONG Zhiyong, ZHOU Xiaozhou, HE Peng, ZHOU Zhansong   +5 more
doaj   +1 more source

Exosomal Dvl3 promoted the aggressive phenotypic transformation of RA-FLS via wnt pathway

Autoimmunity, 2022
Objective This study was performed to explore the function and mechanism of Dvl3 in RA-FLS by exosome intervention. Methods The expression pattern of Dvl3 was examined by IHC, WB, and qPCR.
Weixing Tan, Ning Chen, Yang Qiu, Xiaomei Feng, Shuwen Li, Yongjin Zhang, Haoran Li, Jie Gao, Dongbao Zhao   +8 more
doaj   +1 more source

Granule Cell Dispersion in Human Temporal Lobe Epilepsy: Proteomics investigation of neurodevelopmental migratory pathways [PDF]

, 2020
Granule cell dispersion (GCD) is a common pathological feature observed in the hippocampus of patients with Mesial Temporal Lobe Epilepsy (MTLE). Pathomechanisms underlying GCD remain to be elucidated, but one hypothesis proposes aberrant reactivation of
Al-Kaaby, B., Al-Kaaby, B., Dzurova, N., Dzurova, N., Liu, J., Liu, J., Millks, K., Millks, K., Sisodiya, S.M., Sisodiya, S.M., Thom, M., Thom, M.   +11 more
core   +1 more source