Results 51 to 60 of about 123,069 (394)
DLC2 modulates angiogenic responses in vascular endothelial cells by regulating cell attachment and migration. [PDF]
, 2010 Deleted in liver cancer 1 (DLC1) is a RhoGTPase activation protein-containing tumor suppressor that associates with various types of cancer. Although DLC2 shares a similar domain structure with that of DLC1, the function of DLC2 is not well characterized.
Chen, N-T +5 more
core +3 more sources
Mechanotransduction: from the cell surface to the nucleus via RhoA
Philosophical Transactions of the Royal Society of London. Biological Sciences, 2019 Cells respond and adapt to their physical environments and to the mechanical forces that they experience. The translation of physical forces into biochemical signalling pathways is known as mechanotransduction.
K. Burridge +2 more
semanticscholar +1 more source
RhoA in aneurysmal subarachnoid hemorrhage
Aging, 2019 Aneurysmal subarachnoid haemorrhage (aSAH) is a severe subtype of stroke, mediated by the spontaneous rupture of an intracranial aneurysm, that frequently occurs in people between 40 and 60 years of age. Cerebral vasospasm (CV), and related delayed cerebral ischemia (DCI), is a clinical syndrome of the focal neurologic deficits that develop typically ...
Ureña, Juan +2 more
openaire +4 more sources
Poultry Science, 2022 Cryopreservation of rooster sperm leads to relatively low semen quality due to cytoskeletal damage during the freeze-thawing process. This study aimed to explore how the addition of RhoA recombinant protein affected the viability and subcellular structure of rooster sperm after freeze-thawing and elucidated the molecular mechanisms of sperm ...
Nuo Heng +13 more
openaire +3 more sources
Trends in Peptide and Protein Sciences, 2017 Breast cancer is the most prevalent diagnosed cancer and the second cause of cancer death among women worldwide. There are different mechanisms that play crucial roles in the onset and progression of breast cancer including microRNAs. microRNAs are small
Samira Mohammadi Yeganeh +4 more
doaj +1 more source
Vascular smooth muscle contraction in hypertension [PDF]
, 2018 Hypertension is a major risk factor for many common chronic diseases, such as heart failure, myocardial infarction, stroke, vascular dementia and chronic kidney disease.
Alves-Lopes, Rheure +6 more
core +1 more source
Journal of experimental & clinical cancer research : CR, 2019 BackgroundActivation of CXCL12/CXCR4 axis has been found to be associated with invasion and metastasis in many cancers. However, the underlying mechanism remains elusive.
Xinfeng Yu +8 more
semanticscholar +1 more source
RhoA promotes osteoclastogenesis and regulates bone remodeling through mTOR-NFATc1 signaling
Molecular Medicine, 2023 Background The cytoskeletal architecture of osteoclasts (OCs) and bone resorption activity must be appropriately controlled for proper bone remodeling, which is associated with osteoporosis.
Jirong Wang +8 more
doaj +1 more source
Journal of Neuroinflammation, 2019 Microglial activation contributes to the development of chronic migraine (CM). The P2Y12 receptor (P2Y12R), a metabolic purinoceptor that is expressed on microglia in the central nervous system (CNS), has been indicated to play a critical role in the ...
Feng Jing +7 more
semanticscholar +1 more source
Variegated RHOA mutations in human cancers [PDF]
Experimental Hematology, 2016 RHOA is one of the most extensively investigated members of the Rho GTPase family of proteins and has long been implicated in malignant transformation as well as tumor invasion and metastasis. Recently, revolutionized sequencing platforms have revealed frequent RHOA mutations in a wide variety of human cancers, including angio-immunoblastic T-cell ...
Keisuke, Kataoka, Seishi, Ogawa
openaire +2 more sources