Cholecystokinin-mediated RhoGDI phosphorylation via PKCα promotes both RhoA and Rac1 signaling. [PDF]
PLoS ONE, 2013 RhoA and Rac1 have been implicated in the mechanism of CCK-induced amylase secretion from pancreatic acini. In all cell types studied to date, inactive Rho GTPases are present in the cytosol bound to the guanine nucleotide dissociation inhibitor RhoGDI ...
Maria Eugenia Sabbatini, John A Williams
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Activation of RHOA–VAV1 signaling in angioimmunoblastic T-cell lymphoma [PDF]
, 2017 Somatic G17V RHOA mutations were found in 50–70% of angioimmunoblastic T-cell lymphoma (AITL). The mutant RHOA lacks GTP binding capacity, suggesting defects in the classical RHOA signaling.
Enami T +23 more
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Cell-Instructive Alginate Hydrogels Targeting RhoA [PDF]
Bioconjugate Chemistry, 2018 ISSN:1043 ...
Florian A. Formica +3 more
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The Functional Significance of the Rho/Rho-Kinase Pathway in Human Erythrocytes
Turkish Journal of Hematology, 2014 OBJECTIVE: Erythrocyte deformability, which can be influenced by various intracellular signaling mechanisms, such as nitric oxide, cAMP, cGMP, and protein kinases, is the most important physiological factor providing the blood flow in microcirculation ...
R. Nalan Tiftik +3 more
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Integrin Regulation by RhoA in Thymocytes [PDF]
The Journal of Immunology, 2005 Abstract The guanine nucleotide-binding protein Rho has essential functions in T cell development and is important for the survival and proliferation of T cell progenitors in the thymus. To explore the mechanisms used by RhoA to control thymocyte biology, the role of this GTPase in the regulation of integrin-mediated cell adhesion was ...
Vielkind, Susina +4 more
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RPGR protein complex regulates proteasome activity and mediates store-operated calcium entry [PDF]
, 2018 Ciliopathies are a group of genetically heterogeneous disorders, characterized by defects in cilia genesis or maintenance. Mutations in the RPGR gene and its interacting partners, RPGRIP1 and RPGRIP1L, cause ciliopathies, but the function of their ...
Aguirre +68 more
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A transcriptional cross–talk between RhoA and c–Myc inhibits the RhoA/Rock–dependent cytoskeleton [PDF]
Small GTPases, 2010 The GTPase RhoA participates in a number of cellular processes, including cytoskeletal organization, mitogenesis and tumorigenesis. We have previously shown that the transforming activity of an oncogenic version of RhoA (Q63L mutant) was highly dependent on the transcriptional factor c-Myc.
Sauzeau, Vincent +3 more
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Peptide Bbeta(15-42) preserves endothelial barrier function in shock [PDF]
, 2009 Loss of vascular barrier function causes leak of fluid and proteins into tissues, extensive leak leads to shock and death. Barriers are largely formed by endothelial cell-cell contacts built up by VE-cadherin and are under the control of RhoGTPases. Here
Atrasheuskaya, Alena +12 more
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α8β1 integrin regulates nutrient absorption through an Mfge8-PTEN dependent mechanism. [PDF]
, 2016 Coordinated gastrointestinal smooth muscle contraction is critical for proper nutrient absorption and is altered in a number of medical disorders. In this work, we demonstrate a critical role for the RGD-binding integrin α8β1 in promoting nutrient ...
Atabai, Kamran +12 more
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Complementary receptors control RhoA [PDF]
The Journal of Cell Biology, 2008 ![Graphic][1] Syndecan-4 and integrin both contribute to RhoA regulation. A pair of adhesion receptors work together to fine-tune suppression of RhoA and promote membrane protrusion, say [Bass et al][2].
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