Inhibition of Protein Geranylgeranylation and RhoA/RhoA Kinase Pathway Induces Apoptosis in Human Endothelial Cells [PDF]
Journal of Biological Chemistry, 2002 Geranylgeranylation of RhoA small G-protein is essential for its localization to cell membranes and for its biological functions. Many RhoA effects are mediated by its downstream effector RhoA kinase. The role of protein geranylgeranylation and the RhoA pathway in the regulation of endothelial cell survival has not been elucidated.
Xianwu, Li +7 more
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Functional Genomics Profiling of Bladder Urothelial Carcinoma MicroRNAome as a Potential Biomarker. [PDF]
, 2018 Though bladder urothelial carcinoma is the most common form of bladder cancer, advances in its diagnosis and treatment have been modest in the past few decades.
Li, Wei Tse +4 more
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Graded RhoA GTPase Expression in Treg Cells Distinguishes Tumor Immunity From Autoimmunity
Frontiers in Immunology, 2021 RhoA of the Rho GTPase family is prenylated at its C-terminus. Prenylation of RhoA has been shown to control T helper 17 (Th17) cell-mediated colitis. By characterizing T cell-specific RhoA conditional knockout mice, we have recently shown that RhoA is ...
Khalid W. Kalim +6 more
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Pepducin-mediated cardioprotection via β-arrestin-biased β2-adrenergic receptor-specific signaling [PDF]
, 2018 Reperfusion as a therapeutic intervention for acute myocardial infarction-induced cardiac injury itself induces further cardiomyocyte death. β-arrestin (βarr)-biased β-adrenergic receptor (βAR) activation promotes survival signaling responses in vitro ...
Benovic, Jeffrey L. +7 more
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Animal cell cytokinesis: the role of dynamic changes in the plasma membrane proteome and lipidome [PDF]
, 2016 In animal cells, cytokinesis is characterised by the formation of the mitotic spindle that signals the assembly of an actomyosin ring between the spindle poles.
Gould, Gwyn W.
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PLoS ONE, 2015 Numerous cellular studies have indicated that RhoA signaling is required for oncogenic Ras-induced transformation, suggesting that RhoA is a useful target in Ras induced neoplasia.
Inuk Zandvakili +3 more
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Identification of Naegleria fowleri proteins linked to primary amoebic meningoencephalitis [PDF]
, 2017 Naegleria fowleri (N. fowleri) causes primary amoebic meningoencephalitis, a rapidly fatal disease of the central nervous system. N. fowleri can exist in cyst, flagellate or amoebic forms, depending on environmental conditions.
Cabral, Guy A +4 more
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LINC02381 Promoted Cell Viability and Migration via Targeting miR-133b in Cervical Cancer Cells
Cancer Management and Research, 2020 Xiaohua Chen, Zhuxiang Zhang, Yan Ma, Hongxin Su, Peng Xie, Juntao Ran Department Of Radiation Therapy, First Hospital Of Lanzhou University, Lanzhou City, Gansu Province 730000, People’s Republic of ChinaCorrespondence: Juntao RanDepartment Of ...
Chen X +5 more
doaj
Enriched environment reduces glioma growth through immune and non-immune mechanisms in mice [PDF]
, 2015 Mice exposed to standard (SE) or enriched environment (EE) were transplanted with murine or human glioma cells and differences in tumour development were evaluated.
BENIGNI, GIORGIA +13 more
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Tumor-associated Endo180 requires stromal-derived LOX to promote metastatic prostate cancer cell migration on human ECM surfaces [PDF]
, 2015 The diverse composition and structure of extracellular matrix (ECM) interfaces encountered by tumor cells at secondary tissue sites can influence metastatic progression. Extensive in vitro and in vivo data has confirmed that metastasizing tumor cells can
Caley, Matthew P. +7 more
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