Induced Remodelling of Astrocytes In Vitro and In Vivo by Manipulation of Astrocytic RhoA Activity
Cells, 2023 Structural changes of astrocytes and their perisynaptic processes occur in response to various physiological and pathophysiological stimuli. They are thought to profoundly affect synaptic signalling and neuron-astrocyte communication.
Cátia Domingos +8 more
doaj +1 more source
Functions of p120ctn isoforms in cell-cell adhesion and intracellular signaling [PDF]
, 2012 The functions of many organs depend on the generation of an epithelium. The transition from a set of loosely connected nonpolarized cells to organized sheets of closely associated polarized epithelial cells requires the assembly of specialized cell ...
Pieters, Tim +2 more
core +2 more sources
Pyrin Inflammasome Activation and RhoA Signaling in the Autoinflammatory Diseases FMF and HIDS
Nature Immunology, 2016 Mutations in the genes encoding pyrin and mevalonate kinase (MVK) cause distinct interleukin-1β (IL-1β)-mediated autoinflammatory diseases: familial Mediterranean fever (FMF) and hyperimmunoglobulinemia D syndrome (HIDS). Pyrin forms an inflammasome when
Y. Park, G. Wood, D. Kastner, J. Chae
semanticscholar +1 more source
The Functional Significance of the Rho/Rho-Kinase Pathway in Human Erythrocytes
Turkish Journal of Hematology, 2014 OBJECTIVE: Erythrocyte deformability, which can be influenced by various intracellular signaling mechanisms, such as nitric oxide, cAMP, cGMP, and protein kinases, is the most important physiological factor providing the blood flow in microcirculation ...
R. Nalan Tiftik +3 more
doaj +1 more source
RhoA G17V is sufficient to induce autoimmunity and promotes T-cell lymphomagenesis in mice.
Blood, 2018 Patients with angioimmunoblastic T-cell lymphoma (AITL) and other peripheral T-cell lymphomas that harbor features of follicular helper T (TFH) cells have a very poor prognosis.
S. Ng +6 more
semanticscholar +1 more source
Integrin Regulation by RhoA in Thymocytes [PDF]
The Journal of Immunology, 2005 Abstract The guanine nucleotide-binding protein Rho has essential functions in T cell development and is important for the survival and proliferation of T cell progenitors in the thymus. To explore the mechanisms used by RhoA to control thymocyte biology, the role of this GTPase in the regulation of integrin-mediated cell adhesion was ...
Vielkind, Susina +4 more
openaire +3 more sources
Emerging role of ARHGAP29 in melanoma cell phenotype switching
Molecular Oncology, EarlyView.This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster +3 more
wiley +1 more source
α8β1 integrin regulates nutrient absorption through an Mfge8-PTEN dependent mechanism. [PDF]
, 2016 Coordinated gastrointestinal smooth muscle contraction is critical for proper nutrient absorption and is altered in a number of medical disorders. In this work, we demonstrate a critical role for the RGD-binding integrin α8β1 in promoting nutrient ...
Atabai, Kamran +12 more
core +2 more sources
A mechanosensitive RhoA pathway that protects epithelia against acute tensile stress
bioRxiv, 2018 Adherens junctions are tensile structures that couple epithelial cells together. Junctional tension can arise from cell-intrinsic application of contractility or from the cell-extrinsic forces of tissue movement.
Bipul R. Acharya +6 more
semanticscholar +1 more source
A transcriptional cross–talk between RhoA and c–Myc inhibits the RhoA/Rock–dependent cytoskeleton [PDF]
Small GTPases, 2010 The GTPase RhoA participates in a number of cellular processes, including cytoskeletal organization, mitogenesis and tumorigenesis. We have previously shown that the transforming activity of an oncogenic version of RhoA (Q63L mutant) was highly dependent on the transcriptional factor c-Myc.
Sauzeau, Vincent +3 more
openaire +5 more sources